Gynecomastoid hyperplasia

Gynecomastoid hyperplasia, also gynecomastia, is a benign pathology of the breast classically seen in young men.

General

• Benign enlargement of breasts in males.
  • Histologic changes may be seen in females.

May be seen in the context of:

• Liver failure.
• Klinefelter syndrome.
• Testicular estrogen-producing germ cell tumour.

Microscopic

Features:

• Moderate hyperplasia.
  • Glands have more than 2 cell layers.
• "Budding" - individual cells jut into the lumen - key feature.
  • Buds may be multicellular; however, narrower toward the centre of the lumen.
• Stromal palor.

DDx:

• Micropapillary DCIS - buds not narrower toward the centre of the lumen.

Images

• 

  Gynecomastoid hyperplasia - intermed. mag. (WC/Nephron)

• 

  Gynecomastoid hyperplasia - very high mag. (WC/Nephron)

• 

  Gynecomastoid hyperplasia - 2 - intermed. mag. (WC/Nephron)

www:

• Gynecomastoid hyperplasia (stonybrook.edu).
• Gynecomastia (radiology.uchc.edu).

See also

• Breast pathology.