Granulomatous appendicitis
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Granulomatous appendicitis is an inflammatory process involving the vermiform appendix characterized by granulomas.
General
Most common cause:
- Yersinia appendicitis.[1]
DDx:[2]
- Yersinia appendicitis.[1]
- Yersinia = gram negative rod (red on Gram stain).
- "Safety pin"-like appearance[3] - approximately 0.5 micrometers diameter x 2 micrometers length.
- Other micro-organism (TB, fungus).
- Crohn's disease.
- Sarcoidosis.
- Foreign body reaction.
- Interval (delayed) appendectomy.
- Approximately 60% of delayed appendectomies have granulomas.[4]
Microscopic
Features:
- Granulomas.
- +/-"Safety pin"-like organisms (Yersinia).
Image(s):
Granulomatous Appendicitis (SKB)
Suppurating Granulomatous Appendicitis (SKB)
Suppurating Granulomatous Yersinia Appendicitis (SKB)
Suppurating Granulomatous Yersinia Appendicitis Yersinia(SKB)
See also
References
- ↑ 1.0 1.1 Lamps LW, Madhusudhan KT, Greenson JK, et al. (April 2001). "The role of Yersinia enterocolitica and Yersinia pseudotuberculosis in granulomatous appendicitis: a histologic and molecular study". Am. J. Surg. Pathol. 25 (4): 508–15. PMID 11257626.
- ↑ http://granuloma.homestead.com/appendicitis.html
- ↑ URL: http://www.cdc.gov/ncidod/dvbid/plague/p1.htm. Accessed on: 30 June 2011.
- ↑ Guo, G.; Greenson, JK. (Aug 2003). "Histopathology of interval (delayed) appendectomy specimens: strong association with granulomatous and xanthogranulomatous appendicitis.". Am J Surg Pathol 27 (8): 1147-51. PMID 12883248.