Lymph nodes with isolated tumour cells

From Libre Pathology
Revision as of 12:59, 16 September 2016 by Michael (talk | contribs) (→‎See also)
Jump to navigation Jump to search

Lymph nodes with isolated tumour cells, also isolated tumour cells (abbreviated ITCs) and isolated cancer cells, is the presence of rare cancer cells in a lymph node.

This article is focus on isolated tumour cells in breast pathology.

General

Definition

  • An isolated cluster of tumour cells within a lymph node in one tissue section measuring <= 0.2 mm or <200 tumour cells.[1][2]

Significance

  • Not a significant predictor of outcome in breast pathology.[3]

Sign out

Right Breast, Modified Radical Mastectomy:
     - Two lymph nodes of six lymph nodes with ISOLATED TUMOR CELLS 
	  (<100 tumour cells per lymph node).  
	-- All lymph nodes NEGATIVE for micrometatases and 
	   NEGATIVE for macrometatases (0/4).
     - Scar and therapy changes (hyalization, calcifications) compatible 
       with treated tumour.
     - Florid epithelial hyperplasia of the usual type.
     - Please see synoptic report.

Comment:
The isolated tumour cells were demonstrated with a CAM5.2 immunostain.

See also

References

  1. Reed, J.; Rosman, M.; Verbanac, KM.; Mannie, A.; Cheng, Z.; Tafra, L. (Mar 2009). "Prognostic implications of isolated tumor cells and micrometastases in sentinel nodes of patients with invasive breast cancer: 10-year analysis of patients enrolled in the prospective East Carolina University/Anne Arundel Medical Center Sentinel Node Multicenter Study.". J Am Coll Surg 208 (3): 333-40. doi:10.1016/j.jamcollsurg.2008.10.036. PMID 19317993.
  2. Naidoo, K.; Pinder, SE. (Aug 2016). "Micro- and macro-metastasis in the axillary lymph node: A review.". Surgeon. doi:10.1016/j.surge.2016.07.002. PMID 27498412.
  3. Ahmed, SS.; Thike, AA.; Iqbal, J.; Yong, WS.; Tan, B.; Madhukumar, P.; Ong, KW.; Ho, GH. et al. (Mar 2014). "Sentinel lymph nodes with isolated tumour cells and micrometastases in breast cancer: clinical relevance and prognostic significance.". J Clin Pathol 67 (3): 243-50. doi:10.1136/jclinpath-2013-201771. PMID 24218025.