Choroid plexus papilloma
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| Choroid plexus papilloma | |
|---|---|
| Diagnosis in short | |
 Choroid plexus papilloma H&E stain. | |
|
| |
| LM | papillary epithelial structures with bland cytology, mitoses uncommon |
| LM DDx | choroid plexus carcinoma, metastatic papillary adenocarcinoma, ELST |
| IHC | Kir 7.1 +ve, EAAT1 +ve, GFAP +ve/-ve, S-100 +ve/-ve, CK +ve/-ve |
| Site | all ventricles, cerebellopontine angle - see brain tumours |
|
| |
| Clinical history | children |
| Symptoms | hydrocephalus |
Choroid plexus papilloma, abbreviated CPP, is a benign neuropathology arising in the ventricles of the brain.
General
Features: [1]
- Low grade
- WHO grade I (ICD-O: 9390/1).
- WHO grade II - atypical choroid plexus papilloma (ICD-O: 9390/1).
- Less than 1% of all brain tumours.
- Approximately 10-20% of all tumours in the first year of life.
- Congenital tumours reported.
- Usually laternal ventricle in children.[2]
Gross
Features: [1]
- Adhere to ventricular walls.
- Circumscribed.
- Villous architecture.
- 50% lateral ventricles.
- 5% third ventricle.
- 40% fourth ventricle.
- 5% multiple tumours or cerebellopontine angle.
Microscopic
Features: [3]
- Simple epithelium.
- Papillae.
- Psammoma bodies.
- Rarely oncocytic changes, mucinous degeneration.
- Necrosis and brain invasion is uncommon.
- Atypical CPP: 2 or more mitoses /10 HPF.[4]
DDx:
- Choroid plexus carcinoma.
- Metastatic papillary carcinoma.
- Endolymphatic sac tumour (ELST).
Images
Choroid plexus papilloma can become quite large. (WC/marvin101)
Intraoperative smear of a choroid plexus papilloma. (WC/jensflorian)
Choroid plexus papilloma. (WC)
Elevated proliferative activity (MIB-1) in atypical CPP. (WC/marvin101)
www:
IHC
- CK7 +ve.
- CK20 -ve (typically).
- S-100 +ve/-ve.
- EMA -ve.
- GFAP +ve/-ve.
- Kir 7.1 +ve.
- EAAT1 +ve.
See also
References
- ↑ 1.0 1.1 The International Agency for Research on Cancer (Editors: Louis, D.N.; Ohgaki, H.; Wiestler, O.D.; Cavenee, W.K.) (2007). Pathology and Genetics of Tumours of Tumors of the Central Nervous System (IARC WHO Classification of Tumours) (4th ed.). Lyon: World Health Organization. pp. 82. doi:10.1007/s00401-007-0243-4. ISBN 978-9283224303.
- ↑ URL: http://emedicine.medscape.com/article/250795-overview. Accessed on: 3 June 2011.
- ↑ Menon, G.; Nair, SN.; Baldawa, SS.; Rao, RB.; Krishnakumar, KP.; Gopalakrishnan, CV.. "Choroid plexus tumors: an institutional series of 25 patients.". Neurol India 58 (3): 429-35. doi:10.4103/0028-3886.66455. PMID 20644273.
- ↑ Wrede, B.; Hasselblatt, M.; Peters, O.; Thall, PF.; Kutluk, T.; Moghrabi, A.; Mahajan, A.; Rutkowski, S. et al. (Dec 2009). "Atypical choroid plexus papilloma: clinical experience in the CPT-SIOP-2000 study.". J Neurooncol 95 (3): 383-92. doi:10.1007/s11060-009-9936-y. PMID 19543851.