Choroid plexus carcinoma

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Choroid plexus carcinoma
Diagnosis in short

Choroid plexus carcinoma. H&E stain.

LM choroid plexus epithelium with nuclear pleomorphism & high NC ratio, mitoses, necrosis, +/-brain invasion
LM DDx choroid plexus papilloma, atypical plexus papilloma, atypical teratoid/rhabdoid tumour
IHC cytokeratins +ve, EMA -ve, INI1 +ve, Ki-67 high
Site brain - intraventricular mass, classically posterior fossa

Clinical history typically children
Prevalence uncommon

Choroid plexus carcinoma is an uncommon neuropathology tumour and the malignant counter part of choroid plexus papilloma.

General

  • Usually pediatric population.
  • Malignant counterpart of choroid plexus papilloma.[1]
  • Poor prognosis - WHO grade III.[2]
  • Classically posterior fossa.
  • Intraventricular mass.

Microscopic

Features:[1]

DDx:

Images

www:

IHC

Features:[2]

  • Cytokeratins +ve.
  • EMA usu. -ve.
  • GFAP -ve (~20% +ve).
  • Ki-67 high.
    • Useful to diff. from benign counterpart.
  • INI1 +ve.

See also

References

  1. 1.0 1.1 Singh, A.; Vermani, S.; Shruti, S.. "Choroid plexus carcinoma: report of two cases.". Indian J Pathol Microbiol 52 (3): 405-7. doi:10.4103/0377-4929.55009. PMID 19679976.
  2. 2.0 2.1 2.2 Menon, G.; Nair, SN.; Baldawa, SS.; Rao, RB.; Krishnakumar, KP.; Gopalakrishnan, CV.. "Choroid plexus tumors: an institutional series of 25 patients.". Neurol India 58 (3): 429-35. doi:10.4103/0028-3886.66455. PMID 20644273.