Epithelioid cell lesions

Epithelioid cell lesions are very common in pathology.

Malignant epithelioid lesions are usually a carcinoma.

A short differential diagnosis:

• Carcinoma (primary and metastatic).
• Malignant melanoma.
• Sarcoma.

Epithelioid sarcomas

All rules are made to be broken... some epithelioid lesions are sarcomas:

• Epithelioid sarcoma.
• Epithelioid angiosarcoma.
• Alveolar soft part sarcoma.
• Rhabdoid tumour.

Others:

• Clear cell sarcoma.
• Epithelioid gastrointestinal stromal tumour.
• Synovial sarcoma, primitive round cell type.
• Sarcomas in the small round cell tumours group, e.g. Ewing sarcoma.

An exhaustive DDx of large epithelioid tumour is in large epithelioid tumours.

See also

• Spindle cell lesions.
• Large epithelioid tumours.