Difference between revisions of "Adenosis of the prostate gland"
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'''Adenosis of the prostate''', | '''Adenosis of the prostate gland''', also '''adenosis of the prostate''', is a benign change of the prostate gland, typically seen in the transistion zone of the prostate, and may be mistaken for (low grade) [[prostatic adenocarcinoma]].<ref name=pmid7793471>{{Cite journal | last1 = Gaudin | first1 = PB. | last2 = Epstein | first2 = JI. | title = Adenosis of the prostate. Histologic features in needle biopsy specimens. | journal = Am J Surg Pathol | volume = 19 | issue = 7 | pages = 737-47 | month = Jul | year = 1995 | doi = | PMID = 7793471 }}</ref> | ||
It is also known as '''[[atypical adenomatous hyperplasia]]'''.<ref name=pmid22520603>{{Cite journal | last1 = Molinié | first1 = V. | last2 = Vadrot | first2 = J. | last3 = Duchatelle | first3 = V. | last4 = Balaton | first4 = A. | last5 = Abbey-Tobby | first5 = A. | last6 = Baumert | first6 = H. | title = [Diagnostic issues of prostate biopsies. Case 2. Atypical adenomatous hyperplasia (adenosis)]. | journal = Ann Pathol | volume = 32 | issue = 2 | pages = 114-7 | month = Apr | year = 2012 | doi = 10.1016/j.annpat.2012.02.003 | PMID = 22520603 }}</ref><ref name=pmid23000851>{{Cite journal | last1 = Humphrey | first1 = PA. | title = Atypical adenomatous hyperplasia (adenosis) of the prostate. | journal = J Urol | volume = 188 | issue = 6 | pages = 2371-2 | month = Dec | year = 2012 | doi = 10.1016/j.juro.2012.09.058 | PMID = 23000851 }}</ref> | |||
==General== | |||
*May be mistaken for [[prostatic adenocarcinoma]].<ref name=pmid22212076>{{Cite journal | last1 = Epstein | first1 = JI. | title = Diagnosis of limited adenocarcinoma of the prostate. | journal = Histopathology | volume = 60 | issue = 1 | pages = 28-40 | month = Jan | year = 2012 | doi = 10.1111/j.1365-2559.2011.03990.x | PMID = 22212076 }}</ref> | |||
*Lesion of the transistion zone of the prostate.<ref name=pmid7793471>{{Cite journal | last1 = Gaudin | first1 = PB. | last2 = Epstein | first2 = JI. | title = Adenosis of the prostate. Histologic features in needle biopsy specimens. | journal = Am J Surg Pathol | volume = 19 | issue = 7 | pages = 737-47 | month = Jul | year = 1995 | doi = | PMID = 7793471 }}</ref> | |||
==Microscopic== | |||
Features: | |||
*Glandular crowding. | |||
**Glands may be back-to-back. | |||
*Lack of prominent [[nucleoli]]. | |||
DDx: | |||
*[[Adenocarcinoma of the prostate]] - esp. [[foamy gland adenocarcinoma]]. | |||
==IHC== | |||
*CK5/6 +ve. ‡ | |||
*p63 +ve. ‡ | |||
*AMACR -ve. | |||
Notes: | |||
*‡ Often patchy - some glands in a group may lack basal cells. | |||
==See also== | ==See also== | ||
| Line 5: | Line 28: | ||
==References== | ==References== | ||
{{Reflist| | {{Reflist|2}} | ||
[[Category:Prostate gland]] | [[Category:Prostate gland]] | ||
Revision as of 21:24, 8 June 2015
Adenosis of the prostate gland, also adenosis of the prostate, is a benign change of the prostate gland, typically seen in the transistion zone of the prostate, and may be mistaken for (low grade) prostatic adenocarcinoma.[1]
It is also known as atypical adenomatous hyperplasia.[2][3]
General
- May be mistaken for prostatic adenocarcinoma.[4]
- Lesion of the transistion zone of the prostate.[1]
Microscopic
Features:
- Glandular crowding.
- Glands may be back-to-back.
- Lack of prominent nucleoli.
DDx:
IHC
- CK5/6 +ve. ‡
- p63 +ve. ‡
- AMACR -ve.
Notes:
- ‡ Often patchy - some glands in a group may lack basal cells.
See also
References
- ↑ 1.0 1.1 Gaudin, PB.; Epstein, JI. (Jul 1995). "Adenosis of the prostate. Histologic features in needle biopsy specimens.". Am J Surg Pathol 19 (7): 737-47. PMID 7793471.
- ↑ Molinié, V.; Vadrot, J.; Duchatelle, V.; Balaton, A.; Abbey-Tobby, A.; Baumert, H. (Apr 2012). "[Diagnostic issues of prostate biopsies. Case 2. Atypical adenomatous hyperplasia (adenosis)].". Ann Pathol 32 (2): 114-7. doi:10.1016/j.annpat.2012.02.003. PMID 22520603.
- ↑ Humphrey, PA. (Dec 2012). "Atypical adenomatous hyperplasia (adenosis) of the prostate.". J Urol 188 (6): 2371-2. doi:10.1016/j.juro.2012.09.058. PMID 23000851.
- ↑ Epstein, JI. (Jan 2012). "Diagnosis of limited adenocarcinoma of the prostate.". Histopathology 60 (1): 28-40. doi:10.1111/j.1365-2559.2011.03990.x. PMID 22212076.