Difference between revisions of "Adenoid cystic/basal cell carcinoma of the prostate"

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DDx:
DDx:
*Adenoid cystic-like [[Basal cell hyperplasia of the prostate|basal cell hyperplasia]].<ref name=pmid15371944>{{Cite journal  | last1 = McKenney | first1 = JK. | last2 = Amin | first2 = MB. | last3 = Srigley | first3 = JR. | last4 = Jimenez | first4 = RE. | last5 = Ro | first5 = JY. | last6 = Grignon | first6 = DJ. | last7 = Young | first7 = RH. | title = Basal cell proliferations of the prostate other than usual basal cell hyperplasia: a clinicopathologic study of 23 cases, including four carcinomas, with a proposed classification. | journal = Am J Surg Pathol | volume = 28 | issue = 10 | pages = 1289-98 | month = Oct | year = 2004 | doi =  | PMID = 15371944 }}</ref>
*Adenoid cystic-like [[Basal cell hyperplasia of the prostate|basal cell hyperplasia]]<ref name=pmid15371944>{{Cite journal  | last1 = McKenney | first1 = JK. | last2 = Amin | first2 = MB. | last3 = Srigley | first3 = JR. | last4 = Jimenez | first4 = RE. | last5 = Ro | first5 = JY. | last6 = Grignon | first6 = DJ. | last7 = Young | first7 = RH. | title = Basal cell proliferations of the prostate other than usual basal cell hyperplasia: a clinicopathologic study of 23 cases, including four carcinomas, with a proposed classification. | journal = Am J Surg Pathol | volume = 28 | issue = 10 | pages = 1289-98 | month = Oct | year = 2004 | doi =  | PMID = 15371944 }}</ref> - BCL2 -ve, Ki-67 low.<ref name=pmid9865831/>  


===Images===
===Images===
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*HER2/neu +ve (strong).<ref name=pmid17142577>{{Cite journal  | last1 = Iczkowski | first1 = KA. | last2 = Montironi | first2 = R. | title = Adenoid cystic/basal cell carcinoma of the prostate strongly expresses HER-2/neu. | journal = J Clin Pathol | volume = 59 | issue = 12 | pages = 1327-30 | month = Dec | year = 2006 | doi = 10.1136/jcp.2005.035147 | PMID = 17142577 }}</ref>
*HER2/neu +ve (strong).<ref name=pmid17142577>{{Cite journal  | last1 = Iczkowski | first1 = KA. | last2 = Montironi | first2 = R. | title = Adenoid cystic/basal cell carcinoma of the prostate strongly expresses HER-2/neu. | journal = J Clin Pathol | volume = 59 | issue = 12 | pages = 1327-30 | month = Dec | year = 2006 | doi = 10.1136/jcp.2005.035147 | PMID = 17142577 }}</ref>
*CK34betaE12 +ve ([[Adenoid cystic carcinoma|AdCC]] component).<ref name=pmid15371944/>
*CK34betaE12 +ve ([[Adenoid cystic carcinoma|AdCC]] component).<ref name=pmid15371944/>
 
*BCL2 +ve.<ref name=pmid9865831>{{Cite journal  | last1 = Yang | first1 = XJ. | last2 = McEntee | first2 = M. | last3 = Epstein | first3 = JI. | title = Distinction of basaloid carcinoma of the prostate from benign basal cell lesions by using immunohistochemistry for bcl-2 and Ki-67. | journal = Hum Pathol | volume = 29 | issue = 12 | pages = 1447-50 | month = Dec | year = 1998 | doi =  | PMID = 9865831 }}</ref>
*Ki-67 >20%.<ref name=pmid9865831/>
==See also==
==See also==
*[[Prostate cancer]].
*[[Prostate cancer]].

Revision as of 05:15, 25 February 2015

Adenoid cystic/basal cell carcinoma of the prostate
Diagnosis in short

Adenoid cystic/basal cell carcinoma of the prostate. H&E stain.
LM DDx adenoid cystic-like basal cell hyperplasia
Site prostate gland

Prevalence very rare
Prognosis usually good

Adenoid cystic/basal cell carcinoma of the prostate, abbreviated ACBCC, is a rare from of prostate cancer that resembles adenoid cystic carcinoma and basal cell carcinoma.

It is also known as adenoid cystic carcinoma of the prostate.[1]

General

  • Rare.
  • Typically indolent - may be aggressive.[2]

Microscopic

Features:

DDx:

Images

IHC

  • HER2/neu +ve (strong).[4]
  • CK34betaE12 +ve (AdCC component).[1]
  • BCL2 +ve.[3]
  • Ki-67 >20%.[3]

See also

References

  1. 1.0 1.1 1.2 McKenney, JK.; Amin, MB.; Srigley, JR.; Jimenez, RE.; Ro, JY.; Grignon, DJ.; Young, RH. (Oct 2004). "Basal cell proliferations of the prostate other than usual basal cell hyperplasia: a clinicopathologic study of 23 cases, including four carcinomas, with a proposed classification.". Am J Surg Pathol 28 (10): 1289-98. PMID 15371944.
  2. Iczkowski, KA.; Ferguson, KL.; Grier, DD.; Hossain, D.; Banerjee, SS.; McNeal, JE.; Bostwick, DG. (Dec 2003). "Adenoid cystic/basal cell carcinoma of the prostate: clinicopathologic findings in 19 cases.". Am J Surg Pathol 27 (12): 1523-9. PMID 14657711.
  3. 3.0 3.1 3.2 Yang, XJ.; McEntee, M.; Epstein, JI. (Dec 1998). "Distinction of basaloid carcinoma of the prostate from benign basal cell lesions by using immunohistochemistry for bcl-2 and Ki-67.". Hum Pathol 29 (12): 1447-50. PMID 9865831.
  4. Iczkowski, KA.; Montironi, R. (Dec 2006). "Adenoid cystic/basal cell carcinoma of the prostate strongly expresses HER-2/neu.". J Clin Pathol 59 (12): 1327-30. doi:10.1136/jcp.2005.035147. PMID 17142577.