Difference between revisions of "Papillary cystadenoma of the epididymis"
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==General== | ==General== | ||
*May be associated with [[von Hippel-Lindau disease]].<ref name=pmid23708309/> | *May be associated with [[von Hippel-Lindau disease]].<ref name=pmid23708309/> | ||
**One third of reported cases associated with vHL.<ref name=pmid20367315/> | |||
**Classically bilateral involvement.<ref name=pmid20367315/> | |||
*Large age range (16-76 years old).<ref name=pmid20367315/> | |||
*Typically young adults (median age 30 years old).<ref name=pmid20367315/> | |||
Clinical:<ref name=pmid20367315/> | |||
*Slow growing scrotal mass or incidental finding. | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features:<ref name=pmid20367315/> | ||
* | *Cystic spaces with papillary structures lined by clear cells with moderate cytoplasm. | ||
DDx: | DDx: | ||
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*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679418/figure/fig0020/ PC (nih.gov)].<ref name=pmid23708309/> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679418/figure/fig0020/ PC (nih.gov)].<ref name=pmid23708309/> | ||
*[http://www.archivesofpathology.org/action/showFullPopup?id=i1543-2165-134-4-630-f01&doi=10.1043%2F1543-2165-134.4.630 PC (archivesofpathology.org)].<ref name=pmid20367315>{{Cite journal | last1 = Odrzywolski | first1 = KJ. | last2 = Mukhopadhyay | first2 = S. | title = Papillary cystadenoma of the epididymis. | journal = Arch Pathol Lab Med | volume = 134 | issue = 4 | pages = 630-3 | month = Apr | year = 2010 | doi = 10.1043/1543-2165-134.4.630 | PMID = 20367315 }}</ref> | *[http://www.archivesofpathology.org/action/showFullPopup?id=i1543-2165-134-4-630-f01&doi=10.1043%2F1543-2165-134.4.630 PC (archivesofpathology.org)].<ref name=pmid20367315>{{Cite journal | last1 = Odrzywolski | first1 = KJ. | last2 = Mukhopadhyay | first2 = S. | title = Papillary cystadenoma of the epididymis. | journal = Arch Pathol Lab Med | volume = 134 | issue = 4 | pages = 630-3 | month = Apr | year = 2010 | doi = 10.1043/1543-2165-134.4.630 | PMID = 20367315 }}</ref> | ||
==IHC== | |||
Features:<ref name=pmid20367315>{{Cite journal | last1 = Odrzywolski | first1 = KJ. | last2 = Mukhopadhyay | first2 = S. | title = Papillary cystadenoma of the epididymis. | journal = Arch Pathol Lab Med | volume = 134 | issue = 4 | pages = 630-3 | month = Apr | year = 2010 | doi = 10.1043/1543-2165-134.4.630 | PMID = 20367315 }}</ref> | |||
*AE1/AE3 (7 of 7 cases). | |||
*EMA +ve (9 of 9 cases). | |||
*CK7 +v3 (3 of 3 cases). | |||
Others:<ref name=pmid20367315/> | |||
*Vimentin +ve/-ve (3 of 6 cases +ve). | |||
*CD10 -ve (0 of 5 cases +ve). | |||
*CK20 -ve (0 of 4 cases +ve). | |||
*S100 -ve (1 of 4 cases +ve). | |||
==See also== | ==See also== | ||
Revision as of 16:52, 9 October 2014
Papillary cystadenoma of the epididymis is a rare benign epithelial tumour of the epididymis.[1]
General
- May be associated with von Hippel-Lindau disease.[1]
- Large age range (16-76 years old).[2]
- Typically young adults (median age 30 years old).[2]
Clinical:[2]
- Slow growing scrotal mass or incidental finding.
Microscopic
Features:[2]
- Cystic spaces with papillary structures lined by clear cells with moderate cytoplasm.
DDx:
- Adenomatoid tumour.
- Serous borderline tumour of the paratestis.
- Metastatic clear cell tumours - esp. clear cell renal cell carcinoma.
Images
IHC
Features:[2]
- AE1/AE3 (7 of 7 cases).
- EMA +ve (9 of 9 cases).
- CK7 +v3 (3 of 3 cases).
Others:[2]
- Vimentin +ve/-ve (3 of 6 cases +ve).
- CD10 -ve (0 of 5 cases +ve).
- CK20 -ve (0 of 4 cases +ve).
- S100 -ve (1 of 4 cases +ve).
See also
References
- ↑ 1.0 1.1 1.2 Toutziaris, C.; Kampantais, S.; Perdikis, I.; Gourvas, V.; Laskaridis, L.; Gkagkalidis, K.; Lakis, S.; Ioannidis, S. (2013). "Papillary cystadenoma of epididymis: Is there a need for further investigation in unilateral cases?". Int J Surg Case Rep 4 (7): 616-8. doi:10.1016/j.ijscr.2013.03.038. PMID 23708309.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Odrzywolski, KJ.; Mukhopadhyay, S. (Apr 2010). "Papillary cystadenoma of the epididymis.". Arch Pathol Lab Med 134 (4): 630-3. doi:10.1043/1543-2165-134.4.630. PMID 20367315.