Difference between revisions of "Lung metastasis"

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(Created page with "'''Lung metastasis''', also '''pulmonary metastasis''' and '''metastatic lung disease''', is relatively common and generally carries a poor prognosis. ==General== *Relatively...")
 
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*Variable - dependent on site of origin.
*Variable - dependent on site of origin.


[[Colorectal adenocarcinoma]]:
[[Colorectal adenocarcinoma]] - usually distinctive morphologically:
*Typically gland forming.
*Typically gland forming.
**Ellipsoid/elongated pseudostratified nuclei with moderate [[nuclear atypia]].
**Ellipsoid/elongated pseudostratified nuclei with moderate [[nuclear atypia]].
**+/-Dirty necrosis.
**+/-Dirty necrosis.
Others:
*[[Urothelial carcinoma]] - may mimic [[squamous cell carcinoma of the lung]].
*Upper GI adenocarcinoma (e.g. [[gastric adenocarcinoma]]) - may mimic [[lung adenocarcinoma]].
*Breast carcinoma - esp. [[ductal carcinoma of the breast]] - may mimic [[lung adenocarcinoma]].


==IHC==
==IHC==

Revision as of 19:20, 29 September 2014

Lung metastasis, also pulmonary metastasis and metastatic lung disease, is relatively common and generally carries a poor prognosis.

General

  • Relatively common.

Microscopic

Features:

  • Variable - dependent on site of origin.

Colorectal adenocarcinoma - usually distinctive morphologically:

  • Typically gland forming.
    • Ellipsoid/elongated pseudostratified nuclei with moderate nuclear atypia.
    • +/-Dirty necrosis.

Others:

IHC

  • TTF-1 -ve (may be positive).
  • CK20 +ve/-ve (+ve in colorectal carcinoma, -ve in lung primaries).
  • GATA3 +ve/-ve (usu. +ve in urothelial carcinoma, -ve in lung primaries[1]).

See also

References

  1. Chang, A.; Amin, A.; Gabrielson, E.; Illei, P.; Roden, RB.; Sharma, R.; Epstein, JI. (Oct 2012). "Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung.". Am J Surg Pathol 36 (10): 1472-6. doi:10.1097/PAS.0b013e318260cde7. PMID 22982890.