Difference between revisions of "Solitary fibrous tumour of the pleura"

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#redirect [[Lung_tumours#Solitary_fibrous_tumour_of_the_pleura]]
'''Solitary fibrous tumour of the pleura''', also '''pleural solitary fibrous tumour''', is a relatively common chest wall tumour.
 
The solitary fibrous tumour in general is dealt with in the ''[[solitary fibrous tumour]]'' article.
 
==General==
*Uncommon overall.<ref name=pmid24326857/>
**Common for the anatomical site.
*Benign.
*Slow growing.<ref name=pmid24326857>{{Cite journal  | last1 = Mordenti | first1 = P. | last2 = Di Cicilia | first2 = R. | last3 = Delfanti | first3 = R. | last4 = Capelli | first4 = P. | last5 = Paties | first5 = C. | last6 = Cavanna | first6 = L. | title = Solitary fibrous tumors of the pleura: a case report and review of the literature. | journal = Tumori | volume = 99 | issue = 4 | pages = e177-83 | month =  | year =  | doi = 10.1700/1361.15120 | PMID = 24326857 }}</ref>
*Elderly.
*May be large - impair respiratory function.<ref name=pmid24088920>{{Cite journal  | last1 = Abe | first1 = M. | last2 = Nomori | first2 = H. | last3 = Fukazawa | first3 = M. | last4 = Sugimura | first4 = H. | last5 = Narita | first5 = M. | last6 = Takeshi | first6 = A. | title = Giant Solitary Fibrous Tumor of the Pleura Causing Respiratory Insufficiency: Report of 3 Cases. | journal = Ann Thorac Cardiovasc Surg | volume =  | issue =  | pages =  | month = Oct | year = 2013 | doi =  | PMID = 24088920 }}</ref>
 
==Gross/radiology==
*Chest wall.
 
==Microscopic==
Features:
*Spindle cells - usually bland cytology.
*Patternless pattern.
*+/-Ropy collagen.
 
Suggestive of malignant:<ref name=pmid24088920/>
*Mitotic rate >4/10 HPF.
**Definition suffers from [[HPFitis]].
 
DDx:
*[[Malignant mesothelioma]].
*Metastatic carcinoma.
*[[Lung adenocarcinoma]].
 
===Images===
<gallery>
Image:Pleural solitary fibrous tumor (1).jpg | Pleural SFT. (WC)
Image:Pleural solitary fibrous tumor (2).jpg | Pleural SFT. (WC)
Image:Pleural solitary fibrous tumor (3).jpg | Pleural SFT. (WC)
</gallery>
www:
*[http://path.upmc.edu/cases/case216/dx.html SFT (upmc.edu)].
 
==IHC==
Features:
*CD34 +ve (19/23 cases<ref name=pmid15460417>{{Cite journal  | last1 = Chen | first1 = HJ. | last2 = Zhang | first2 = HY. | last3 = Li | first3 = X. | last4 = Guo | first4 = LX. | last5 = Wei | first5 = B. | last6 = Guo | first6 = H. | last7 = Bu | first7 = H. | last8 = Yang | first8 = K. | last9 = Liu | first9 = BL. | title = [Solitary fibrous tumor: the clinicopathologic and immunohistochemical characteristics of 26 cases]. | journal = Sichuan Da Xue Xue Bao Yi Xue Ban | volume = 35 | issue = 5 | pages = 675-9 | month = Sep | year = 2004 | doi =  | PMID = 15460417 }}</ref>).
*Ki-67 low (<5%).<ref name=pmid24088920/>
*Vimentin +ve (23/23 cases<ref name=pmid15460417/>).
*BCL2 +ve (23/23 cases<ref name=pmid15460417/>).
*CD99 +ve (23/23 cases<ref name=pmid15460417/>).
*SMA -ve/+ve (7 +ve/23 cases<ref name=pmid15460417/>).
 
Suggested stains:{{fact}}
*CD34, CD99, BCL2, S-100, Ki-67.
 
==Sign out==
<pre>
LEFT LUNG ("LARGE PLEURAL BASED MASS"), BIOPSY:
- SOLITARY FIBROUS TUMOUR.
</pre>
 
===Micro===
The sections show cellular fibrous tissue with a patternless pattern. No mitotic activity is readily apparent. No significant nuclear atypia is identified. No necrosis is apparent.
 
==See also==
*[[Solitary fibrous tumour]].
 
==References==
{{Reflist|2}}
 
[[Category:Diagnosis]]
[[Category:Lung tumours]]

Revision as of 03:34, 18 February 2014

Solitary fibrous tumour of the pleura, also pleural solitary fibrous tumour, is a relatively common chest wall tumour.

The solitary fibrous tumour in general is dealt with in the solitary fibrous tumour article.

General

  • Uncommon overall.[1]
    • Common for the anatomical site.
  • Benign.
  • Slow growing.[1]
  • Elderly.
  • May be large - impair respiratory function.[2]

Gross/radiology

  • Chest wall.

Microscopic

Features:

  • Spindle cells - usually bland cytology.
  • Patternless pattern.
  • +/-Ropy collagen.

Suggestive of malignant:[2]

  • Mitotic rate >4/10 HPF.

DDx:

Images

  • Pleural SFT. (WC)

  • Pleural SFT. (WC)

  • Pleural SFT. (WC)

www:

IHC

Features:

  • CD34 +ve (19/23 cases[3]).
  • Ki-67 low (<5%).[2]
  • Vimentin +ve (23/23 cases[3]).
  • BCL2 +ve (23/23 cases[3]).
  • CD99 +ve (23/23 cases[3]).
  • SMA -ve/+ve (7 +ve/23 cases[3]).

Suggested stains:[citation needed]

  • CD34, CD99, BCL2, S-100, Ki-67.

Sign out

LEFT LUNG ("LARGE PLEURAL BASED MASS"), BIOPSY:
- SOLITARY FIBROUS TUMOUR.

Micro

The sections show cellular fibrous tissue with a patternless pattern. No mitotic activity is readily apparent. No significant nuclear atypia is identified. No necrosis is apparent.

See also

References

  1. ↑ 1.0 1.1 Mordenti, P.; Di Cicilia, R.; Delfanti, R.; Capelli, P.; Paties, C.; Cavanna, L.. "Solitary fibrous tumors of the pleura: a case report and review of the literature.". Tumori 99 (4): e177-83. doi:10.1700/1361.15120. PMID 24326857.
  2. ↑ 2.0 2.1 2.2 Abe, M.; Nomori, H.; Fukazawa, M.; Sugimura, H.; Narita, M.; Takeshi, A. (Oct 2013). "Giant Solitary Fibrous Tumor of the Pleura Causing Respiratory Insufficiency: Report of 3 Cases.". Ann Thorac Cardiovasc Surg. PMID 24088920.
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Chen, HJ.; Zhang, HY.; Li, X.; Guo, LX.; Wei, B.; Guo, H.; Bu, H.; Yang, K. et al. (Sep 2004). "[Solitary fibrous tumor: the clinicopathologic and immunohistochemical characteristics of 26 cases].". Sichuan Da Xue Xue Bao Yi Xue Ban 35 (5): 675-9. PMID 15460417.
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