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Difference between revisions of "Gastrointestinal stromal tumour"
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Gastrointestinal stromal tumour (view source)
Revision as of 18:10, 18 August 2013
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Gastrointestinal_stromal_tumour_-_high_mag.jpg | |||
| Width = | |||
| Caption = Gastrointestinal stromal tumour. [[H&E stain]]. | |||
| Micro = spindle cell ''or'' epithelioid ''or'' mixed morphology | |||
| Subtypes = | |||
| LMDDx = [[schwannoma]], [[leiomyoma]], [[leiomyosarcoma]], [[neurofibroma]], [[desmoid-type fibromatosis]] | |||
| Stains = | |||
| IHC = CD34 +ve, CD117 +ve, DOG-1 +ve, S-100 -ve | |||
| EM = | |||
| Molecular = mutation in KIT gene ''or'' PDGFRA gene | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[stomach]], [[small intestine]], other sites | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = good to poor - dependent is size, site & mitotic rate | |||
| Other = | |||
| ClinDDx = | |||
}} | |||
The '''gastrointestinal stromal tumour''', abbreviated '''GIST''', is an uncommon tumour of the [[gastrointestinal tract pathology|gastrointestinal tract]]. | The '''gastrointestinal stromal tumour''', abbreviated '''GIST''', is an uncommon tumour of the [[gastrointestinal tract pathology|gastrointestinal tract]]. | ||
==General== | ==General== | ||
===Definition=== | ===Definition=== | ||
*Tumour resulting from a mutation in the | *Tumour resulting from a mutation in the KIT gene ''or'' PDGFRA (Platelet-derived growth factor receptor, alpha polypeptide) gene.<ref name=pmid17090188/> | ||
===Epidemiology=== | ===Epidemiology=== | ||