Difference between revisions of "Invasive breast cancer"

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**Usually negative; -ve in 70-80%.<ref>Lester. 2nd Ed. PP.241-2.</ref>
**Usually negative; -ve in 70-80%.<ref>Lester. 2nd Ed. PP.241-2.</ref>
**Positivity association with a worse prognosis.
**Positivity association with a worse prognosis.


===ER & PR scoring<ref>Lester. 2nd Ed. PP.241-2.</ref>===
===ER & PR scoring<ref>Lester. 2nd Ed. PP.241-2.</ref>===
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***<10% = low positivity - treated.
***<10% = low positivity - treated.


Notes:
*Normal breast epithelial cells have a patchy staining for ER and PR.
*Evaluated on the invasive component.
===HER2 scoring<ref>Lester. 2nd Ed. PP.241-2.</ref>===  
===HER2 scoring<ref>Lester. 2nd Ed. PP.241-2.</ref>===  
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Notes:
*Normal breast epithelial cells do not stain with HER2.
*Evaluated on the invasive component.
===Clinical===
===Clinical===
*ER & PR status determine whether a patient will get tamoxifen or other estrogen modulators.
*ER & PR status determine whether a patient will get tamoxifen or other estrogen modulators.
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