Difference between revisions of "Invasive breast cancer"

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**May have a thick fibrous capsule = ''encapsulated papillary carcinoma''.<ref name=pmid21057133/>

*Loss of myoepithelial cells - '''key feature'''.

*Scattered large cells with pale eosinophilic cytoplasm may be observed<ref>{{Cite journal | last1 = Collins | first1 = LC. | last2 = Schnitt | first2 = SJ. | title = Papillary lesions of the breast: selected diagnostic and management issues. | journal = Histopathology | volume = 52 | issue = 1 | pages = 20-9 | month = Jan | year = 2008 | doi = 10.1111/j.1365-2559.2007.02898.x | PMID = 18171414 }}

</ref>.

**These cells are so-called globoid cells or clear cells and are immunoreactive for GCDFP-15.

**They should not be mistaken for myoepithelial cells.

*Neoplastic epithelial cells:

**[[Nuclear atypia]] - including: nucleoli, [[nuclear pleomorphism]].

Difference between revisions of "Invasive breast cancer"

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@@ Line 497: / Line 497: @@
 **May have a thick fibrous capsule = ''encapsulated papillary carcinoma''.<ref name=pmid21057133/>
 *Loss of myoepithelial cells - '''key feature'''.
+*Scattered large cells with pale eosinophilic cytoplasm may be observed<ref>{{Cite journal  | last1 = Collins | first1 = LC. | last2 = Schnitt | first2 = SJ. | title = Papillary lesions of the breast: selected diagnostic and management issues. | journal = Histopathology | volume = 52 | issue = 1 | pages = 20-9 | month = Jan | year = 2008 | doi = 10.1111/j.1365-2559.2007.02898.x | PMID = 18171414 }}
+</ref>.
+**These cells are so-called globoid cells or clear cells and are immunoreactive for GCDFP-15.
+**They should not be mistaken for myoepithelial cells.
 *Neoplastic epithelial cells:
 **[[Nuclear atypia]] - including: nucleoli, [[nuclear pleomorphism]].