Difference between revisions of "Invasive breast cancer"

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==Medullary breast carcinoma==
==Medullary breast carcinoma==
*[[AKA]] ''medullary carcinoma of the breast''.
*[[AKA]] ''medullary carcinoma of the breast''.
===General===
{{Main|Medullary breast carcinoma}}
*Uncommon breast cancer subtype.
*Some pathologists don't believe this exists.
 
Epidemiology:
*Thought to have a better prognosis that no special type (NST).
*May be associated with a BRCA1 mutation.
 
===Gross===
*Well-circumscribed border.<ref name=pmid21071383>{{Cite journal  | last1 = Yoo | first1 = JL. | last2 = Woo | first2 = OH. | last3 = Kim | first3 = YK. | last4 = Cho | first4 = KR. | last5 = Yong | first5 = HS. | last6 = Seo | first6 = BK. | last7 = Kim | first7 = A. | last8 = Kang | first8 = EY. | title = Can MR Imaging contribute in characterizing well-circumscribed breast carcinomas? | journal = Radiographics | volume = 30 | issue = 6 | pages = 1689-702 | month = Oct | year = 2010 | doi = 10.1148/rg.306105511 | PMID = 21071383 }}</ref>
 
Aside - malignant well-circumscribed breast masses - radiologic DDx:<ref name=pmid21071383/>
*Medullary breast carcinoma.
*[[Mucinous breast carcinoma]].
*[[Phyllodes tumour|Malignant phyllodes tumour]].
*[[Invasive papillary carcinoma of the breast]].
 
===Microscopic===
Features:
#Lesion has well-circumscribed border.
#Syncytial growth pattern = clumps of cells with poorly defined cell borders.
#Lymphocytic infiltrate.
#High nuclear grade (as per Nottingham grading system).
#No tubule formation.
 
===IHC===
Features - typical:<ref>{{Cite journal  | last1 = Matkovic | first1 = B. | last2 = Juretic | first2 = A. | last3 = Separovic | first3 = V. | last4 = Novosel | first4 = I. | last5 = Separovic | first5 = R. | last6 = Gamulin | first6 = M. | last7 = Kruslin | first7 = B. | title = Immunohistochemical analysis of ER, PR, HER-2, CK 5/6, p63 and EGFR antigen expression in medullary breast cancer. | journal = Tumori | volume = 94 | issue = 6 | pages = 838-44 | month =  | year =  | doi =  | PMID = 19267102 }}</ref>
*ER -ve.
*PR -ve.
*HER2 -ve.


==Tubular carcinoma of the breast==
==Tubular carcinoma of the breast==
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