Difference between revisions of "Granulomatous appendicitis"

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#redirect [[Vermiform_appendix#Granulomatous_appendicitis]]
'''Granulomatous appendicitis''' is an inflammatory process involving the [[vermiform appendix]] characterized by [[granulomas]].
 
==General==
Most common cause:
*Yersinia appendicitis.<ref name=pmid11257626>{{cite journal |author=Lamps LW, Madhusudhan KT, Greenson JK, ''et al.'' |title=The role of Yersinia enterocolitica and Yersinia pseudotuberculosis in granulomatous appendicitis: a histologic and molecular study |journal=Am. J. Surg. Pathol. |volume=25 |issue=4 |pages=508–15 |year=2001 |month=April |pmid=11257626 |doi= |url=}}</ref>
 
DDx:<ref>[http://granuloma.homestead.com/appendicitis.html http://granuloma.homestead.com/appendicitis.html]</ref>
*Yersinia appendicitis.<ref name=pmid11257626>{{cite journal |author=Lamps LW, Madhusudhan KT, Greenson JK, ''et al.'' |title=The role of Yersinia enterocolitica and Yersinia pseudotuberculosis in granulomatous appendicitis: a histologic and molecular study |journal=Am. J. Surg. Pathol. |volume=25 |issue=4 |pages=508–15 |year=2001 |month=April |pmid=11257626 |doi= |url=}}</ref>
**Yersinia = gram negative rod (red on [[Gram stain]]).
**"Safety pin"-like appearance<ref>URL: [http://www.cdc.gov/ncidod/dvbid/plague/p1.htm http://www.cdc.gov/ncidod/dvbid/plague/p1.htm]. Accessed on: 30 June 2011.</ref> - approximately 0.5 micrometers diameter x 2 micrometers length.
*Other micro-organism ([[TB]], fungus).
*[[Crohn's disease]].
*[[Sarcoidosis]].
*Foreign body reaction.
*Interval (delayed) appendectomy.
**Approximately 60% of delayed appendectomies have granulomas.<ref name=pmid12883248>{{Cite journal  | last1 = Guo | first1 = G. | last2 = Greenson | first2 = JK. | title = Histopathology of interval (delayed) appendectomy specimens: strong association with granulomatous and xanthogranulomatous appendicitis. | journal = Am J Surg Pathol | volume = 27 | issue = 8 | pages = 1147-51 | month = Aug | year = 2003 | doi =  | PMID = 12883248 }}</ref>
 
==Microscopic==
Features:
*[[Granulomas]].
*+/-"Safety pin"-like organisms (Yersinia).
 
Image(s):
<gallery>
Image:Appendix Appendicitis Acute Granulomatous 2 PA.JPG|Granulomatous Appendicitis (SKB)
Image:Appendix Appendicitis Acute Granulomatous PA.JPG|Suppurating Granulomatous Appendicitis (SKB)
Image:Appendix Appendicitis GranulomatousSuppurating Yersinia-LP PA.JPG|Suppurating Granulomatous Yersinia Appendicitis (SKB)
Image:Appendix Appendicitis GranulomatousSuppurating Yersinia-HP PA.JPG|Suppurating Granulomatous Yersinia Appendicitis  Yersinia(SKB)
</gallery>
*[http://www.cdc.gov/ncidod/dvbid/plague/p1.htm Yersinia (CDC)].
 
==See also==
*[[Vermiform appendix]].
 
==References==
{{Reflist|1}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Vermiform appendix]]

Revision as of 16:30, 23 October 2015

Granulomatous appendicitis is an inflammatory process involving the vermiform appendix characterized by granulomas.

General

Most common cause:

  • Yersinia appendicitis.[1]

DDx:[2]

  • Yersinia appendicitis.[1]
    • Yersinia = gram negative rod (red on Gram stain).
    • "Safety pin"-like appearance[3] - approximately 0.5 micrometers diameter x 2 micrometers length.
  • Other micro-organism (TB, fungus).
  • Crohn's disease.
  • Sarcoidosis.
  • Foreign body reaction.
  • Interval (delayed) appendectomy.
    • Approximately 60% of delayed appendectomies have granulomas.[4]

Microscopic

Features:

  • Granulomas.
  • +/-"Safety pin"-like organisms (Yersinia).

Image(s):

See also

References

  1. 1.0 1.1 Lamps LW, Madhusudhan KT, Greenson JK, et al. (April 2001). "The role of Yersinia enterocolitica and Yersinia pseudotuberculosis in granulomatous appendicitis: a histologic and molecular study". Am. J. Surg. Pathol. 25 (4): 508–15. PMID 11257626.
  2. http://granuloma.homestead.com/appendicitis.html
  3. URL: http://www.cdc.gov/ncidod/dvbid/plague/p1.htm. Accessed on: 30 June 2011.
  4. Guo, G.; Greenson, JK. (Aug 2003). "Histopathology of interval (delayed) appendectomy specimens: strong association with granulomatous and xanthogranulomatous appendicitis.". Am J Surg Pathol 27 (8): 1147-51. PMID 12883248.