Difference between revisions of "Smoking-related interstitial fibrosis"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = | |||
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| Synonyms = | |||
| Micro = septal thickening of alveoli with thick collagen bundles (described as "ropy") and hyperplastic smooth muscle fibres; minimal inflammation | |||
| Subtypes = | |||
| LMDDx = [[usual interstitial pneumonia]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = subpleural and centrilobular predominance | |||
| Grossing = | |||
| Staging = | |||
| Site = [[lung]] | |||
| Assdx = [[emphysema]], [[respiratory bronchiolitis]] | |||
| Syndromes = | |||
| Clinicalhx = [[smoking]] | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign, better than UIP | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Smoking-related interstitial fibrosis''', abbreviated '''SRIF''', is a benign pauci-inflammatory scarring associated with [[smoking]]. | '''Smoking-related interstitial fibrosis''', abbreviated '''SRIF''', is a benign pauci-inflammatory scarring associated with [[smoking]]. | ||
Revision as of 16:03, 23 March 2017
| Smoking-related interstitial fibrosis | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | septal thickening of alveoli with thick collagen bundles (described as "ropy") and hyperplastic smooth muscle fibres; minimal inflammation |
| LM DDx | usual interstitial pneumonia |
| Gross | subpleural and centrilobular predominance |
| Site | lung |
|
| |
| Associated Dx | emphysema, respiratory bronchiolitis |
| Clinical history | smoking |
| Prognosis | benign, better than UIP |
Smoking-related interstitial fibrosis, abbreviated SRIF, is a benign pauci-inflammatory scarring associated with smoking.
General
- Associated with emphysema and respiratory bronchiolitis.[1]
Clinical:
- Much better prognosis than UIP with emphysema - five year survival 86% (SRIF) versus 41% (UIP).[2]
Gross
- Subpleural and centrilobular predominance.[1]
Microscopic
Features:[1]
- Septal thickening of alveoli with:
- Thick collagen bundles - may be described as "ropy".[3]
- Hyperplastic smooth muscle fibres.
- Minimal inflammation.
DDx:
- Usual interstitial pneumonia - has inflammation.
Images
See also
References
- ↑ 1.0 1.1 1.2 Katzenstein, AL. (Jan 2012). "Smoking-related interstitial fibrosis (SRIF), pathogenesis and treatment of usual interstitial pneumonia (UIP), and transbronchial biopsy in UIP.". Mod Pathol 25 Suppl 1: S68-78. doi:10.1038/modpathol.2011.154. PMID 22214972.
- ↑ 2.0 2.1 Chae, KJ.; Jin, GY.; Jung, HN.; Kwon, KS.; Choi, H.; Lee, YC.; Chung, MJ.; Park, HS. (2016). "Differentiating Smoking-Related Interstitial Fibrosis (SRIF) from Usual Interstitial Pneumonia (UIP) with Emphysema Using CT Features Based on Pathologically Proven Cases.". PLoS One 11 (9): e0162231. doi:10.1371/journal.pone.0162231. PMID 27611866.
- ↑ 3.0 3.1 Primiani, A.; Dias-Santagata, D.; Iafrate, AJ.; Kradin, RL. (2014). "Pulmonary adenocarcinoma mutation profile in smokers with smoking-related interstitial fibrosis.". Int J Chron Obstruct Pulmon Dis 9: 525-31. doi:10.2147/COPD.S61932. PMID 24920890.