Difference between revisions of "Programmed cell death 1"

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'''Programmed cell death 1''', abbreviated '''PDCD1''' and '''PD1''',<ref name=omim600244>{{OMIM|600244}}</ref> is a protein (and gene) with an important role in  immune system regulation and [[cancer]]. It is found on the T lymphocytes.
'''Programmed cell death 1''', abbreviated '''PDCD1''' and '''PD1''',<ref name=omim600244>{{OMIM|600244}}</ref> is a protein (and gene) with an important role in  immune system regulation and [[cancer]]. It is found on T lymphocytes.


It is also known as '''CD279'''.  
It is also known as '''CD279'''.  

Revision as of 02:45, 12 May 2016

Programmed cell death 1, abbreviated PDCD1 and PD1,[1] is a protein (and gene) with an important role in immune system regulation and cancer. It is found on T lymphocytes.

It is also known as CD279.

PD1 binds with programmed death-ligand 1 (dealt with separately) and programmed death-ligand 2.[2]

Background

Cytotoxic T cell function is regulated by receptor pairs found on the tumour and lymphocyte:[2]

Pairings Tumour cell T cell
Antigen presenting MHC TCR
Inhibitory signal PD-1 PD-L1 (CD274), PD-L2 (CD273)

Drugs

  • Pembrolizumab.
  • Nivolumab.
  • Pidilizumab.

See also

References

  1. Online 'Mendelian Inheritance in Man' (OMIM) 600244
  2. 2.0 2.1 Ribas, A. (Jun 2012). "Tumor immunotherapy directed at PD-1.". N Engl J Med 366 (26): 2517-9. doi:10.1056/NEJMe1205943. PMID 22658126.