Difference between revisions of "Papillary cystadenoma of the epididymis"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      =
| Width      =
| Caption    =
| Synonyms  =
| Micro      = cystic spaces with papillae lined by clear cells with moderate cytoplasm
| Subtypes  =
| LMDDx      = serous borderline tumour of the paratestis, [[adenomatoid tumour]], metastatic [[clear cell carcinoma]] (esp. [[clear cell renal cell carcinoma]])
| Stains    =
| IHC        = AE1/AE3 +ve, EMA +ve, CD10 -ve
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[epididymis]]
| Assdx      =
| Syndromes  = [[von Hippel-Lindau disease]]
| Clinicalhx =
| Signs      =
| Symptoms  = +/-scrotal swelling
| Prevalence = rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    = testicular masses
| Tx        = excision
}}
'''Papillary cystadenoma of the epididymis''' is a rare benign epithelial tumour of the epididymis.<ref name=pmid23708309>{{Cite journal  | last1 = Toutziaris | first1 = C. | last2 = Kampantais | first2 = S. | last3 = Perdikis | first3 = I. | last4 = Gourvas | first4 = V. | last5 = Laskaridis | first5 = L. | last6 = Gkagkalidis | first6 = K. | last7 = Lakis | first7 = S. | last8 = Ioannidis | first8 = S. | title = Papillary cystadenoma of epididymis: Is there a need for further investigation in unilateral cases? | journal = Int J Surg Case Rep | volume = 4 | issue = 7 | pages = 616-8 | month =  | year = 2013 | doi = 10.1016/j.ijscr.2013.03.038 | PMID = 23708309 }}</ref>
'''Papillary cystadenoma of the epididymis''' is a rare benign epithelial tumour of the epididymis.<ref name=pmid23708309>{{Cite journal  | last1 = Toutziaris | first1 = C. | last2 = Kampantais | first2 = S. | last3 = Perdikis | first3 = I. | last4 = Gourvas | first4 = V. | last5 = Laskaridis | first5 = L. | last6 = Gkagkalidis | first6 = K. | last7 = Lakis | first7 = S. | last8 = Ioannidis | first8 = S. | title = Papillary cystadenoma of epididymis: Is there a need for further investigation in unilateral cases? | journal = Int J Surg Case Rep | volume = 4 | issue = 7 | pages = 616-8 | month =  | year = 2013 | doi = 10.1016/j.ijscr.2013.03.038 | PMID = 23708309 }}</ref>


Revision as of 16:57, 9 October 2014

Papillary cystadenoma of the epididymis
Diagnosis in short
LM cystic spaces with papillae lined by clear cells with moderate cytoplasm
LM DDx serous borderline tumour of the paratestis, adenomatoid tumour, metastatic clear cell carcinoma (esp. clear cell renal cell carcinoma)
IHC AE1/AE3 +ve, EMA +ve, CD10 -ve
Site epididymis
Syndromes von Hippel-Lindau disease
Symptoms +/-scrotal swelling
Prevalence rare
Prognosis benign
Clin. DDx testicular masses
Treatment excision

Papillary cystadenoma of the epididymis is a rare benign epithelial tumour of the epididymis.[1]

General

  • May be associated with von Hippel-Lindau disease.[1]
    • One third of reported cases associated with vHL.[2]
    • Classically bilateral involvement.[2]
  • Large age range (16-76 years old).[2]
  • Typically young adults (median age 30 years old).[2]

Clinical:[2]

  • Slow growing scrotal mass or incidental finding.

Microscopic

Features:[2]

  • Cystic spaces with papillary structures lined by clear cells with moderate cytoplasm.

DDx:

Images

IHC

Features:[2]

  • AE1/AE3 (7 of 7 cases).
  • EMA +ve (9 of 9 cases).
  • CK7 +v3 (3 of 3 cases).

Others:[2]

  • Vimentin +ve/-ve (3 of 6 cases +ve).
  • CD10 -ve (0 of 5 cases +ve).
  • CK20 -ve (0 of 4 cases +ve).
  • S100 -ve (1 of 4 cases +ve).

See also

References

  1. ↑ 1.0 1.1 1.2 Toutziaris, C.; Kampantais, S.; Perdikis, I.; Gourvas, V.; Laskaridis, L.; Gkagkalidis, K.; Lakis, S.; Ioannidis, S. (2013). "Papillary cystadenoma of epididymis: Is there a need for further investigation in unilateral cases?". Int J Surg Case Rep 4 (7): 616-8. doi:10.1016/j.ijscr.2013.03.038. PMID 23708309.
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Odrzywolski, KJ.; Mukhopadhyay, S. (Apr 2010). "Papillary cystadenoma of the epididymis.". Arch Pathol Lab Med 134 (4): 630-3. doi:10.1043/1543-2165-134.4.630. PMID 20367315.
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