Difference between revisions of "Lung metastasis"
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==IHC== | ==IHC== | ||
*TTF-1 -ve | *TTF-1 -ve/+ve. | ||
*CK20 +ve/-ve | **Negative suggestive of metastasis... unless it is [[squamous carcinoma]]. | ||
*GATA3 +ve/-ve | *CK20 +ve/-ve. | ||
*CK7 -ve/+ve | **Positive in colorectal carcinoma - very useful. | ||
**Negative in lung primaries. | |||
*GATA3 +ve/-ve. | |||
**Usu. +ve in [[urothelial carcinoma]]. | |||
**Negative in lung primaries.<ref>{{Cite journal | last1 = Chang | first1 = A. | last2 = Amin | first2 = A. | last3 = Gabrielson | first3 = E. | last4 = Illei | first4 = P. | last5 = Roden | first5 = RB. | last6 = Sharma | first6 = R. | last7 = Epstein | first7 = JI. | title = Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung. | journal = Am J Surg Pathol | volume = 36 | issue = 10 | pages = 1472-6 | month = Oct | year = 2012 | doi = 10.1097/PAS.0b013e318260cde7 | PMID = 22982890 }}</ref> | |||
*CK7 -ve/+ve. | |||
**Positive in lung adenocarcinoma and small carcinoma of the lung. | |||
**Positive in a number of other tumours - breast, upper GI tract, thyroid, mesothelioma, [[salivary gland]]. | |||
**Negative in poorly differentiated carcinoma of the lung and squamous carcinoma of the lung. | |||
==See also== | ==See also== | ||
Revision as of 19:32, 29 September 2014
Lung metastasis, also pulmonary metastasis and metastatic lung disease, is relatively common and generally carries a poor prognosis.
General
- Relatively common.
Microscopic
Features:
- Variable - dependent on site of origin.
Colorectal adenocarcinoma - usually distinctive morphologically:
- Typically gland forming.
- Ellipsoid/elongated pseudostratified nuclei with moderate nuclear atypia.
- +/-Dirty necrosis.
Others:
- Urothelial carcinoma - may mimic squamous cell carcinoma of the lung.
- Upper GI adenocarcinoma (e.g. gastric adenocarcinoma) - may mimic lung adenocarcinoma.
- Breast carcinoma - esp. ductal carcinoma of the breast - may mimic lung adenocarcinoma.
IHC
- TTF-1 -ve/+ve.
- Negative suggestive of metastasis... unless it is squamous carcinoma.
- CK20 +ve/-ve.
- Positive in colorectal carcinoma - very useful.
- Negative in lung primaries.
- GATA3 +ve/-ve.
- Usu. +ve in urothelial carcinoma.
- Negative in lung primaries.[1]
- CK7 -ve/+ve.
- Positive in lung adenocarcinoma and small carcinoma of the lung.
- Positive in a number of other tumours - breast, upper GI tract, thyroid, mesothelioma, salivary gland.
- Negative in poorly differentiated carcinoma of the lung and squamous carcinoma of the lung.
See also
References
- ↑ Chang, A.; Amin, A.; Gabrielson, E.; Illei, P.; Roden, RB.; Sharma, R.; Epstein, JI. (Oct 2012). "Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung.". Am J Surg Pathol 36 (10): 1472-6. doi:10.1097/PAS.0b013e318260cde7. PMID 22982890.