Difference between revisions of "Collagenous spherulosis"

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==General==
==General==
*Benign.
*Benign.
*Usually an incidental (microscopic) finding.<ref name=pmid12523815/>
*Usually an incidental (microscopic) finding.<ref name=pmid12523815>{{Cite journal  | last1 = Jan | first1 = YJ. | last2 = Li | first2 = MC. | last3 = Ho | first3 = WL. | title = Collagenous spherulosis presenting as a mass of the breast. | journal = Zhonghua Yi Xue Za Zhi (Taipei) | volume = 65 | issue = 10 | pages = 494-7 | month = Oct | year = 2002 | doi =  | PMID = 12523815 }}</ref>
*Can mimic [[ADH]], [[cribriform DCIS]], [[adenoid cystic carcinoma of the breast|adenoid cystic carcinoma]].<ref name=pmid16330938>{{Cite journal  | last1 = Resetkova | first1 = E. | last2 = Albarracin | first2 = C. | last3 = Sneige | first3 = N. | title = Collagenous spherulosis of breast: morphologic study of 59 cases and review of the literature. | journal = Am J Surg Pathol | volume = 30 | issue = 1 | pages = 20-7 | month = Jan | year = 2006 | doi =  | PMID = 16330938 }}</ref>
*Can mimic [[ADH]], [[cribriform DCIS]], [[adenoid cystic carcinoma of the breast|adenoid cystic carcinoma]].<ref name=pmid16330938>{{Cite journal  | last1 = Resetkova | first1 = E. | last2 = Albarracin | first2 = C. | last3 = Sneige | first3 = N. | title = Collagenous spherulosis of breast: morphologic study of 59 cases and review of the literature. | journal = Am J Surg Pathol | volume = 30 | issue = 1 | pages = 20-7 | month = Jan | year = 2006 | doi =  | PMID = 16330938 }}</ref>
**Epidemiologically, it may be associated with [[LCIS]].<ref name=pmid16330938/>
**Epidemiologically, it may be associated with [[LCIS]].<ref name=pmid16330938/>

Revision as of 20:42, 16 February 2014

Collagenous spherulosis is a benign change of the breast that can be confused for a malignancy.

It is also known as mucinous spherulosis, and spherulosis.[1]

General

Gross

  • Usually small.

Note:

  • May present as a larger mass.[4][5]

Microscopic

Features:[1][6]

  • Tubular/cribriform architecture.
  • Intratubular eosinophilic material - key feature.
    • Classical: Arranged like the spokes of a wheel ("radial spikes").
    • Atypical: Granules ~ 1-2 micrometers.
  • No mitotic activity.
  • Two cells populations (epithelial & myoepithelial) - like a well-behaved breast gland.

Notes:

  • Usually small lesions: < 50 spherules per lesion, <100 micrometers.
  • May be multifocal.
  • +/-Calcifications - may prompt biopsy.

DDx:

Images

www:

See also

References

  1. 1.0 1.1 URL: http://surgpathcriteria.stanford.edu/breast/collspher/. Accessed on: 4 September 2011.
  2. Jan, YJ.; Li, MC.; Ho, WL. (Oct 2002). "Collagenous spherulosis presenting as a mass of the breast.". Zhonghua Yi Xue Za Zhi (Taipei) 65 (10): 494-7. PMID 12523815.
  3. 3.0 3.1 Resetkova, E.; Albarracin, C.; Sneige, N. (Jan 2006). "Collagenous spherulosis of breast: morphologic study of 59 cases and review of the literature.". Am J Surg Pathol 30 (1): 20-7. PMID 16330938.
  4. Hill, P.; Cawson, J.. "Collagenous spherulosis presenting as a mass lesion on imaging.". Breast J 14 (3): 301-3. doi:10.1111/j.1524-4741.2008.00580.x. PMID 18476887.
  5. Jan, YJ.; Li, MC.; Ho, WL. (Oct 2002). "Collagenous spherulosis presenting as a mass of the breast.". Zhonghua Yi Xue Za Zhi (Taipei) 65 (10): 494-7. PMID 12523815.
  6. URL: http://www.hsc.stonybrook.edu/breast-atlas/V-33.htm. Accessed on: 31 August 2011.