Difference between revisions of "Necrosis"

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**Post-mortem it is not found.
**Post-mortem it is not found.


Images (necrosis):
===Images===
*www:
<gallery>
**[http://www0.sun.ac.za/ortho/webct-ortho/tb/tb-histology.html Necrosis at the centre of a granuloma (sun.ac.za)].
Image:Cat_scratch_disease_-_very_high_mag.jpg | Necrosis in cat scratch disease (WC/Nephron)
**[http://www.biomedical-engineering-online.com/content/9/1/10/figure/F7?highres=y Necrosis (biomedical-engineering-online.com)].
Image:Histiocytic_necrotizing_lymphadenitis_-_very_high_mag.jpg | Necrosis in histiocytic necrotizing lymphadenitis (WC/Nephron)
**[http://www.nature.com/bmt/journal/v39/n9/fig_tab/1705646f1.html Necrosis (nature.com)].
Image:Systemic_lupus_erythematosus_lymphadenopathy_-_high_mag.jpg | Necrosis in SLE lymphadenopathy (WC/Nephron)
**[http://moon.ouhsc.edu/kfung/jty1/Com08/Com08Image/Com801-1-09.gif Necrosis (ouhsc.edu)].<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/Com08/Com801-1-Diss.htm http://moon.ouhsc.edu/kfung/jty1/Com08/Com801-1-Diss.htm]. Accessed on: 3 November 2010.</ref>
Image:Fat_necrosis_-_high_mag.jpg | Fat necrosis - high mag. (WC/Nephron)
*[[WC]]:
</gallery>
**[http://commons.wikimedia.org/wiki/File:Cat_scratch_disease_-_very_high_mag.jpg Necrosis in cat scratch disease (WC)].
www:
**[http://commons.wikimedia.org/wiki/File:Histiocytic_necrotizing_lymphadenitis_-_very_high_mag.jpg Necrosis in histiocytic necrotizing lymphadenitis (WC)].
*[http://www0.sun.ac.za/ortho/webct-ortho/tb/tb-histology.html Necrosis at the centre of a granuloma (sun.ac.za)].
**[http://commons.wikimedia.org/wiki/File:Systemic_lupus_erythematosus_lymphadenopathy_-_high_mag.jpg Necrosis in SLE lymphadenopathy (WC)].
*[http://www.biomedical-engineering-online.com/content/9/1/10/figure/F7?highres=y Necrosis (biomedical-engineering-online.com)].
**[http://commons.wikimedia.org/wiki/File:Fat_necrosis_-_high_mag.jpg Fat necrosis - high mag. (WC)].
*[http://www.nature.com/bmt/journal/v39/n9/fig_tab/1705646f1.html Necrosis (nature.com)].
*[http://moon.ouhsc.edu/kfung/jty1/Com08/Com08Image/Com801-1-09.gif Necrosis (ouhsc.edu)].<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/Com08/Com801-1-Diss.htm http://moon.ouhsc.edu/kfung/jty1/Com08/Com801-1-Diss.htm]. Accessed on: 3 November 2010.</ref>


==Stains==
==Stains==

Revision as of 01:24, 19 May 2013

Necrosis is a type of cell death that is characterized by inflammation.

It is always pathologic. The differential diagnosis of necrosis is very broad; it is important to not be focused only on cancer and infections.

Classic types

As per Robbins:[1]

  • Coagulative.
  • Liquefactive.
  • Gangreneous.
  • Caseous.
  • Fatty necrosis.
  • Fibrinoid.

Coagulative

Features:[2]

  • General: most common; proteinlysis > autolysis/heterolysis.
  • Where/when: all tissue except the brain.
  • Microscopic: cell outlines present.

Liquefactive

Features:[2]

  • General: proteinlysis < autolysis/heterolysis.
  • Where/when: infections, brain, abscess.
  • Microscopic: nothing left; pink on H&E.

Other classic types

  • Gangrenous: coagulative necrosis in ischemic limb.
  • Caseous: chessy material; tuberculosis.
  • Fat: adipose tissue, e.g. pancreatitis.
  • Fibrinoid: immune complex mediated; bright-pink in vessel walls.

Other types

Gross

Coagulative necrosis:

  • Soft.
  • Grey or white.

Liquefactive necrosis:

  • Mushy, grey.
  • Porridge-like consistency.

Image:

Microscopic

Features:[3]

  • Dead cells - (too much pink on H&E) - one of the following:
    1. Anucleate cells ("Ghost cells") - outlines of cells only.
      • Usually subtle.
      • Fluffy appearance.
    2. Karyolysis - nucleus disintegrating.
    3. Karyorrhexis - nucleus fragmenting.
    4. Pyknosis - nuclear strinkage.
      • Weak sign.
  • Inflammation - typically neutrophils (very common).

DDx of necrosis:

  • Fibrin.

Notes:

  • Inflammation is a reactive phenomenon; it requires blood flow.
    • Post-mortem it is not found.

Images

  • Necrosis in cat scratch disease (WC/Nephron)

  • Necrosis in histiocytic necrotizing lymphadenitis (WC/Nephron)

  • Necrosis in SLE lymphadenopathy (WC/Nephron)

  • Fat necrosis - high mag. (WC/Nephron)

www:

Stains

See also

References

  1. ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 21-22. ISBN 0-7216-0187-1.
  2. ↑ 2.0 2.1 Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 6. ISBN 978-1416054542.
  3. ↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 4. ISBN 978-1416054542.
  4. ↑ URL: http://moon.ouhsc.edu/kfung/jty1/Com08/Com801-1-Diss.htm. Accessed on: 3 November 2010.
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