Difference between revisions of "Small cell carcinoma"
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*Small cell carcinoma. | *Small cell carcinoma. | ||
*Follicle-like spaces. | *Follicle-like spaces. | ||
Images: | |||
*[http://webpathology.com/image.asp?n=6&Case=531 OSSCHT - low mag. (webpathology.com)]. | |||
*[http://webpathology.com/image.asp?case=531&n=5 OSSCHT - high mag. (webpathology.com)]. | |||
=See also= | =See also= | ||
Revision as of 23:51, 12 December 2011
Small cell carcinoma is a type of carcinoma. It is mostly commonly from the lung ~95% of cases.[1]
Overview
Grouping
May be grouped as:[1]
- Pulmonary.
- Gastrointestinal.
- Genitourinary.
- Head & neck.
- Breast.
- Other.
Sites other than lung
General
Classic tumour with paraneoplastic syndromes - may be associated with:[4]
- Syndrome of inappropriate antidiuretic hormone secretion (SIADH).
- Clinical: hyponatremia.
- Paraneoplastic cerebellar degeneration.
- Lambert-Eaton myasthenic syndrome.
Microscopic
Features:
- Small cells -- typically 15-20 micrometers ~ 2x the size of RBC.
- Scant cytoplasm.
- Stippled chromatin.
- +/-Nuclear moulding.
Images:
- Small cell carcinoma - cytology (WC).
- Metastatic small cell carcinoma - high mag. (WC).
- Metastatic small cell carcinoma - very high mag. (WC).
DDx:
Special types
Ovarian small cell carcinoma of the hypercalcemic type
- AKA small cell carcinoma, hypercalcemic type, AKA small cell carcinoma of the ovary, hypercalcemic type.
General
- Hypercalcemia.[5]
- Rare.
Microscopic
Features:[5]
- Small cell carcinoma.
- Follicle-like spaces.
Images:
See also
- Lung tumours.
- Azzopardi phenomenon.
- Chloroma (AKA granulocytic sarcoma, myeloid sarcoma).
References
- ↑ 1.0 1.1 Grossman, RA.; Pedroso, FE.; Byrne, MM.; Koniaris, LG.; Misra, S. (May 2011). "Does surgery or radiation therapy impact survival for patients with extrapulmonary small cell cancers?". J Surg Oncol. doi:10.1002/jso.21976. PMID 21618245.
- ↑ Cesaretti, M.; Guarnieri, A.; Gaggelli, I.; Tirone, A.; Francioli, N.; Carli, AF.. "Small cell carcinoma of the breast. Report of a case.". Ann Ital Chir 82 (1): 61-4. PMID 21657157.
- ↑ Beach, DF.; Klump, WJ.; Haddad, G.; Reid, LM.; Schwarting, R.; Hageboutros, A. (Jun 2011). "Extrapulmonary small cell: a novel case of small cell carcinoma of the thyroid gland.". Med Oncol. doi:10.1007/s12032-011-9996-7. PMID 21644012.
- ↑ Sher, T.; Dy, GK.; Adjei, AA. (Mar 2008). "Small cell lung cancer.". Mayo Clin Proc 83 (3): 355-67. PMID 18316005.
- ↑ 5.0 5.1 Young, RH.; Oliva, E.; Scully, RE. (Nov 1994). "Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases.". Am J Surg Pathol 18 (11): 1102-16. PMID 7943531.