Difference between revisions of "Transitional cell carcinoma of the ovary"

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#redirect [[Ovarian_tumours#Transitional_cell_carcinoma_of_the_ovary]]
'''Transitional cell carcinoma of the ovary''' is a rare malignant [[ovarian tumour]].  It is thought to be related to high-grade [[serous carcinoma of the ovary]].
 
==General==
*Rare.
*Traditionally in the ''transistional cell tumours'' category - in the surface epithelial group of ovarian tumours.<ref name=Ref_WMSP401>{{Ref WMSP|401}}</ref>
*Thought to be related to high-grade [[serous carcinoma of the ovary|serous carcinoma]].<ref name=pmid23018212>{{Cite journal  | last1 = Ali | first1 = RH. | last2 = Seidman | first2 = JD. | last3 = Luk | first3 = M. | last4 = Kalloger | first4 = S. | last5 = Gilks | first5 = CB. | title = Transitional cell carcinoma of the ovary is related to high-grade serous carcinoma and is distinct from malignant brenner tumor. | journal = Int J Gynecol Pathol | volume = 31 | issue = 6 | pages = 499-506 | month = Nov | year = 2012 | doi = 10.1097/PGP.0b013e31824d7445 | PMID = 23018212 }}</ref>
 
==Microscopic==
Features:<ref name=pmid15087664>{{Cite journal  | last1 = Eichhorn | first1 = JH. | last2 = Young | first2 = RH. | title = Transitional cell carcinoma of the ovary: a morphologic study of 100 cases with emphasis on differential diagnosis. | journal = Am J Surg Pathol | volume = 28 | issue = 4 | pages = 453-63 | month = Apr | year = 2004 | doi =  | PMID = 15087664 }}</ref>
*Cystic spaces:
**Small - punched-out border - very common.
**Large.
*Papillae, usu. large, blunt.
**Occasionally small and filiform.
*+/-Bizarre giant cells (35%)
*+/-Gland-like tubules.
*+/-Squamous differentiation.
*+/-[[Psammoma bodies]].
*Cells:
**Moderate basophilic cytoplasm and little intervening stroma.
**Marked nuclear pleomorphism.
**Mitoses - common.
 
Notes:
#Resembles [[urothelial carcinoma]].<ref name=pmid21073751>{{Cite journal  | last1 = Tazi | first1 = EM. | last2 = Lalya | first2 = I. | last3 = Tazi | first3 = MF. | last4 = Ahellal | first4 = Y. | last5 = M'rabti | first5 = H. | last6 = Errihani | first6 = H. | title = Transitional cell carcinoma of the ovary: a rare case and review of literature. | journal = World J Surg Oncol | volume = 8 | issue =  | pages = 98 | month =  | year = 2010 | doi = 10.1186/1477-7819-8-98 | PMID = 21073751 }}</ref>
#'''No''' Brenner tumour component (benign or malignant) should be present.<ref name=pmid21073751/>
 
===Images===
<gallery>
Image:Transitional_cell_carcinoma_of_the_ovary_-_very_low_mag.jpg | TCC - very low mag. (WC)
Image:Transitional_cell_carcinoma_of_the_ovary_-_low_mag.jpg | TCC - low mag. (WC)
Image:Transitional_cell_carcinoma_of_the_ovary_-_intermed_mag.jpg | TCC - intermed. mag. (WC)
Image:Transitional_cell_carcinoma_of_the_ovary_-_high_mag.jpg | TCC - high mag. (WC)
Image:Transitional_cell_carcinoma_of_the_ovary_-_very_high_mag.jpg | TCC - very high mag. (WC)
</gallery>
 
==IHC==
Features:<ref name=pmid21073751>{{Cite journal  | last1 = Tazi | first1 = EM. | last2 = Lalya | first2 = I. | last3 = Tazi | first3 = MF. | last4 = Ahellal | first4 = Y. | last5 = M'rabti | first5 = H. | last6 = Errihani | first6 = H. | title = Transitional cell carcinoma of the ovary: a rare case and review of literature. | journal = World J Surg Oncol | volume = 8 | issue =  | pages = 98 | month =  | year = 2010 | doi = 10.1186/1477-7819-8-98 | PMID = 21073751 }}</ref>
#Vimentin +ve,
#CA-125 +ve.
#WT1 +ve.
#CK20 -ve.
#Thrombomodulin -ve.
#Uroplakin III -ve.
 
Notes:
*1-6 usu. opposite pattern in urothelial cell carcinoma.
 
==See also==
*[[Urothelial carcinoma]].
*[[Serous carcinoma of the ovary]].
*[[Ovarian tumours]].
 
==References==
{{Reflist|2}}
 
[[Category:Diagnosis]]
[[Category:Ovarian tumours]]

Latest revision as of 06:29, 22 October 2014

Transitional cell carcinoma of the ovary is a rare malignant ovarian tumour. It is thought to be related to high-grade serous carcinoma of the ovary.

General

  • Rare.
  • Traditionally in the transistional cell tumours category - in the surface epithelial group of ovarian tumours.[1]
  • Thought to be related to high-grade serous carcinoma.[2]

Microscopic

Features:[3]

  • Cystic spaces:
    • Small - punched-out border - very common.
    • Large.
  • Papillae, usu. large, blunt.
    • Occasionally small and filiform.
  • +/-Bizarre giant cells (35%)
  • +/-Gland-like tubules.
  • +/-Squamous differentiation.
  • +/-Psammoma bodies.
  • Cells:
    • Moderate basophilic cytoplasm and little intervening stroma.
    • Marked nuclear pleomorphism.
    • Mitoses - common.

Notes:

  1. Resembles urothelial carcinoma.[4]
  2. No Brenner tumour component (benign or malignant) should be present.[4]

Images

  • TCC - very low mag. (WC)

  • TCC - low mag. (WC)

  • TCC - intermed. mag. (WC)

  • TCC - high mag. (WC)

  • TCC - very high mag. (WC)

IHC

Features:[4]

  1. Vimentin +ve,
  2. CA-125 +ve.
  3. WT1 +ve.
  4. CK20 -ve.
  5. Thrombomodulin -ve.
  6. Uroplakin III -ve.

Notes:

  • 1-6 usu. opposite pattern in urothelial cell carcinoma.

See also

References

  1. ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 401. ISBN 978-0781765275.
  2. ↑ Ali, RH.; Seidman, JD.; Luk, M.; Kalloger, S.; Gilks, CB. (Nov 2012). "Transitional cell carcinoma of the ovary is related to high-grade serous carcinoma and is distinct from malignant brenner tumor.". Int J Gynecol Pathol 31 (6): 499-506. doi:10.1097/PGP.0b013e31824d7445. PMID 23018212.
  3. ↑ Eichhorn, JH.; Young, RH. (Apr 2004). "Transitional cell carcinoma of the ovary: a morphologic study of 100 cases with emphasis on differential diagnosis.". Am J Surg Pathol 28 (4): 453-63. PMID 15087664.
  4. ↑ 4.0 4.1 4.2 Tazi, EM.; Lalya, I.; Tazi, MF.; Ahellal, Y.; M'rabti, H.; Errihani, H. (2010). "Transitional cell carcinoma of the ovary: a rare case and review of literature.". World J Surg Oncol 8: 98. doi:10.1186/1477-7819-8-98. PMID 21073751.
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