Difference between revisions of "Anaplastic pilocytic astrocytoma"
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==General== | ==General== | ||
*High-grade [[astrocytoma]] - behaviour | *High-grade [[astrocytoma]] - behaviour corresponded in older classifications to ''WHO Grade III''. | ||
*Some authors prefered the designation '''pilocytic astrocytoma with anaplastic features'''. | *Some authors prefered the designation '''pilocytic astrocytoma with anaplastic features'''. | ||
*Less than 2% of all pilocytic astrocytomas.<ref>{{Cite journal | last1 = Rodriguez | first1 = FJ. | last2 = Scheithauer | first2 = BW. | last3 = Burger | first3 = PC. | last4 = Jenkins | first4 = S. | last5 = Giannini | first5 = C. | title = Anaplasia in pilocytic astrocytoma predicts aggressive behavior. | journal = Am J Surg Pathol | volume = 34 | issue = 2 | pages = 147-60 | month = Feb | year = 2010 | doi = 10.1097/PAS.0b013e3181c75238 | PMID = 20061938 }}</ref> | *Less than 2% of all pilocytic astrocytomas.<ref>{{Cite journal | last1 = Rodriguez | first1 = FJ. | last2 = Scheithauer | first2 = BW. | last3 = Burger | first3 = PC. | last4 = Jenkins | first4 = S. | last5 = Giannini | first5 = C. | title = Anaplasia in pilocytic astrocytoma predicts aggressive behavior. | journal = Am J Surg Pathol | volume = 34 | issue = 2 | pages = 147-60 | month = Feb | year = 2010 | doi = 10.1097/PAS.0b013e3181c75238 | PMID = 20061938 }}</ref> | ||
Latest revision as of 13:52, 17 October 2022
Anaplastic pilocytic astrocytoma, abbreviated APA, is an outdated tumor terminology. Most of these tumors are now classified either as High-grade astrocytoma with piloid features, Pleomorphic xanthoastrocytoma or as Glioblastoma, IDH-wildtype.
General
- High-grade astrocytoma - behaviour corresponded in older classifications to WHO Grade III.
- Some authors prefered the designation pilocytic astrocytoma with anaplastic features.
- Less than 2% of all pilocytic astrocytomas.[1]
- De novo cases in the setting of neurofibromatosis 1 reported.
- Many tumors have history of previous radiation.
Old microscopic criteria
Features:[2]
- At least 4 mitoses/10 high power fields - see HPFitis.
- Hypercellularity.
- Necrosis +/-.
- Pilocytic like (biphasic) - most common.
- Eosinophilic granular bodies +/-.
- Small cell (32%)
- Epithelioid cells (15%)
- Fibrillary areas resembling diffuse astrocytoma.
IHC
Features:[3]
- GFAP +ve (fibres).
- p53: +ve.
- KI-67: high 25%.
- ATRX loss may be present.[4]
- IDH1 (R132H) -ve.
- H3F3A (K27M) -ve.
See also
References
- ↑ Rodriguez, FJ.; Scheithauer, BW.; Burger, PC.; Jenkins, S.; Giannini, C. (Feb 2010). "Anaplasia in pilocytic astrocytoma predicts aggressive behavior.". Am J Surg Pathol 34 (2): 147-60. doi:10.1097/PAS.0b013e3181c75238. PMID 20061938.
- ↑ Rodriguez, FJ.; Scheithauer, BW.; Burger, PC.; Jenkins, S.; Giannini, C. (Feb 2010). "Anaplasia in pilocytic astrocytoma predicts aggressive behavior.". Am J Surg Pathol 34 (2): 147-60. doi:10.1097/PAS.0b013e3181c75238. PMID 20061938.
- ↑ Rodriguez, FJ.; Scheithauer, BW.; Burger, PC.; Jenkins, S.; Giannini, C. (Feb 2010). "Anaplasia in pilocytic astrocytoma predicts aggressive behavior.". Am J Surg Pathol 34 (2): 147-60. doi:10.1097/PAS.0b013e3181c75238. PMID 20061938.
- ↑ Ebrahimi, A.; Skardelly, M.; Bonzheim, I.; Ott, I.; Mühleisen, H.; Eckert, F.; Tabatabai, G.; Schittenhelm, J. (Jun 2016). "ATRX immunostaining predicts IDH and H3F3A status in gliomas.". Acta Neuropathol Commun 4 (1): 60. doi:10.1186/s40478-016-0331-6. PMID 27311324.