Difference between revisions of "Lymph nodes with isolated tumour cells"

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'''Lymph nodes with isolated tumour cells''', also '''isolated tumour cells''' and '''isolated cancer cells''', is the presence of rare cancer cells in a lymph node.
'''Lymph nodes with isolated tumour cells''', also '''isolated tumour cells''' (abbreviated '''ITCs''') and '''isolated cancer cells''', is the presence of rare cancer cells in a lymph node.


This article is focus on ''isolated tumour cells'' in [[breast pathology]].
This article is focused on ''isolated tumour cells'' in [[breast pathology]].


==General==
==General==
===Definition===
===Definition===
*An isolated cluster of tumour cells within a lymph node in one tissue section measuring <= 0.2 mm ''or'' <200 tumour cells.<ref name=pmid19317993> {{Cite journal  | last1 = Reed | first1 = J. | last2 = Rosman | first2 = M. | last3 = Verbanac | first3 = KM. | last4 = Mannie | first4 = A. | last5 = Cheng | first5 = Z. | last6 = Tafra | first6 = L. | title = Prognostic implications of isolated tumor cells and micrometastases in sentinel nodes of patients with invasive breast cancer: 10-year analysis of patients enrolled in the prospective East Carolina University/Anne Arundel Medical Center Sentinel Node Multicenter Study. | journal = J Am Coll Surg | volume = 208 | issue = 3 | pages = 333-40 | month = Mar | year = 2009 | doi = 10.1016/j.jamcollsurg.2008.10.036 | PMID = 19317993 }}</ref><ref>{{Cite journal  | last1 = Naidoo | first1 = K. | last2 = Pinder | first2 = SE. | title = Micro- and macro-metastasis in the axillary lymph node: A review. | journal = Surgeon | volume =  | issue =  | pages =  | month = Aug | year = 2016 | doi = 10.1016/j.surge.2016.07.002 | PMID = 27498412 }}</ref>
*An isolated cluster of tumour cells within a lymph node in one tissue section measuring <= 0.2 mm ''or'' <=200 tumour cells.<ref name=pmid19317993> {{Cite journal  | last1 = Reed | first1 = J. | last2 = Rosman | first2 = M. | last3 = Verbanac | first3 = KM. | last4 = Mannie | first4 = A. | last5 = Cheng | first5 = Z. | last6 = Tafra | first6 = L. | title = Prognostic implications of isolated tumor cells and micrometastases in sentinel nodes of patients with invasive breast cancer: 10-year analysis of patients enrolled in the prospective East Carolina University/Anne Arundel Medical Center Sentinel Node Multicenter Study. | journal = J Am Coll Surg | volume = 208 | issue = 3 | pages = 333-40 | month = Mar | year = 2009 | doi = 10.1016/j.jamcollsurg.2008.10.036 | PMID = 19317993 }}</ref><ref>{{Cite journal  | last1 = Naidoo | first1 = K. | last2 = Pinder | first2 = SE. | title = Micro- and macro-metastasis in the axillary lymph node: A review. | journal = Surgeon | volume =  | issue =  | pages =  | month = Aug | year = 2016 | doi = 10.1016/j.surge.2016.07.002 | PMID = 27498412 }}</ref>


===Significance===
===Significance===
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==See also==
==See also==
*[[Invasive breast cancer]].
*[[Invasive breast cancer]].
*[[Breast cancer staging]].
*[[Lymph node metastasis]].
*[[Lymph node metastasis]].


Latest revision as of 13:07, 16 September 2016

Lymph nodes with isolated tumour cells, also isolated tumour cells (abbreviated ITCs) and isolated cancer cells, is the presence of rare cancer cells in a lymph node.

This article is focused on isolated tumour cells in breast pathology.

General

Definition

  • An isolated cluster of tumour cells within a lymph node in one tissue section measuring <= 0.2 mm or <=200 tumour cells.[1][2]

Significance

  • Not a significant predictor of outcome in breast pathology.[3]

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Right Breast, Modified Radical Mastectomy:
     - Two lymph nodes of six lymph nodes with ISOLATED TUMOR CELLS 
	  (<100 tumour cells per lymph node).  
	-- All lymph nodes NEGATIVE for micrometatases and 
	   NEGATIVE for macrometatases (0/4).
     - Scar and therapy changes (hyalization, calcifications) compatible 
       with treated tumour.
     - Florid epithelial hyperplasia of the usual type.
     - Please see synoptic report.

Comment:
The isolated tumour cells were demonstrated with a CAM5.2 immunostain.

See also

References

  1. ↑ Reed, J.; Rosman, M.; Verbanac, KM.; Mannie, A.; Cheng, Z.; Tafra, L. (Mar 2009). "Prognostic implications of isolated tumor cells and micrometastases in sentinel nodes of patients with invasive breast cancer: 10-year analysis of patients enrolled in the prospective East Carolina University/Anne Arundel Medical Center Sentinel Node Multicenter Study.". J Am Coll Surg 208 (3): 333-40. doi:10.1016/j.jamcollsurg.2008.10.036. PMID 19317993.
  2. ↑ Naidoo, K.; Pinder, SE. (Aug 2016). "Micro- and macro-metastasis in the axillary lymph node: A review.". Surgeon. doi:10.1016/j.surge.2016.07.002. PMID 27498412.
  3. ↑ Ahmed, SS.; Thike, AA.; Iqbal, J.; Yong, WS.; Tan, B.; Madhukumar, P.; Ong, KW.; Ho, GH. et al. (Mar 2014). "Sentinel lymph nodes with isolated tumour cells and micrometastases in breast cancer: clinical relevance and prognostic significance.". J Clin Pathol 67 (3): 243-50. doi:10.1136/jclinpath-2013-201771. PMID 24218025.
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