Difference between revisions of "Vimentin"

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'''Vimentin''' is a common [[immunostain]].  It marks most [[soft tissue lesions]] and [[malignant melanoma]].  It is usually negative in carcinoma.
[[Image:Poorly differentiated carcinoma -- vimentin - intermed mag.jpg|thumb|300px|Vimentin staining in a poorly differentiated [[carcinoma]].]]
[[Image:Lymphoma - lung - vimentin -- intermed mag.jpg|thumb|300px|Vimentin staining in a [[lymphoma]].]]
'''Vimentin''' is a common [[immunostain]].  It marks most [[soft tissue lesions]] and [[malignant melanoma]].  It is usually negative in carcinomas.


==Positive==
==Positive==
*Most [[sarcoma]]s.
*Most [[sarcoma]]s.
*[[Malignant melanoma]].<ref name=pmid27052289>{{Cite journal  | last1 = Mısır | first1 = AF. | last2 = Durmuşlar | first2 = MC. | last3 = Zerener | first3 = T. | last4 = Gün | first4 = BD. | title = Primary malignant melanoma. | journal = Saudi Med J | volume = 37 | issue = 4 | pages = 446-9 | month = Apr | year = 2016 | doi = 10.15537/smj.2016.4.15017 | PMID = 27052289 }}</ref>
*[[Malignant melanoma]].<ref name=pmid27052289>{{Cite journal  | last1 = Mısır | first1 = AF. | last2 = Durmuşlar | first2 = MC. | last3 = Zerener | first3 = T. | last4 = Gün | first4 = BD. | title = Primary malignant melanoma. | journal = Saudi Med J | volume = 37 | issue = 4 | pages = 446-9 | month = Apr | year = 2016 | doi = 10.15537/smj.2016.4.15017 | PMID = 27052289 }}</ref>
*[[Lymphoma]]s - many.<ref name=pmid2524200>{{Cite journal  | last1 = Domagala | first1 = W. | last2 = Lasota | first2 = J. | last3 = Chosia | first3 = M. | last4 = Weber | first4 = K. | last5 = Osborn | first5 = M. | title = Leukocyte-common antigen and vimentin are reliable adjuncts in the diagnosis of non-Hodgkin's lymphoma in fine needle aspirates. | journal = Anal Quant Cytol Histol | volume = 11 | issue = 1 | pages = 15-21 | month = Feb | year = 1989 | doi =  | PMID = 2524200 }}</ref><ref name=pmid1711289>{{Cite journal  | last1 = Gustmann | first1 = C. | last2 = Altmannsberger | first2 = M. | last3 = Osborn | first3 = M. | last4 = Griesser | first4 = H. | last5 = Feller | first5 = AC. | title = Cytokeratin expression and vimentin content in large cell anaplastic lymphomas and other non-Hodgkin's lymphomas. | journal = Am J Pathol | volume = 138 | issue = 6 | pages = 1413-22 | month = Jun | year = 1991 | doi =  | PMID = 1711289 }}</ref>
===Vimentin and cytokeratin positivity===
Common tumours:
*[[Renal cell carcinoma]].<ref name=pmid18318577/>
*[[Endometrial carcinoma]].<ref name=pmid12647218>{{Cite journal  | last1 = Alkushi | first1 = A. | last2 = Irving | first2 = J. | last3 = Hsu | first3 = F. | last4 = Dupuis | first4 = B. | last5 = Liu | first5 = CL. | last6 = Rijn | first6 = M. | last7 = Gilks | first7 = CB. | title = Immunoprofile of cervical and endometrial adenocarcinomas using a tissue microarray. | journal = Virchows Arch | volume = 442 | issue = 3 | pages = 271-7 | month = Mar | year = 2003 | doi = 10.1007/s00428-002-0752-4 | PMID = 12647218 }}</ref>
*[[Ovarian serous carcinoma]].<ref name=pmid18318577>{{Cite journal  | last1 = Bahrami | first1 = A. | last2 = Truong | first2 = LD. | last3 = Ro | first3 = JY. | title = Undifferentiated tumor: true identity by immunohistochemistry. | journal = Arch Pathol Lab Med | volume = 132 | issue = 3 | pages = 326-48 | month = Mar | year = 2008 | doi = 10.1043/1543-2165(2008)132[326:UTTIBI]2.0.CO;2 | PMID = 18318577 }}</ref>
*[[Papillary thyroid carcinoma]].<ref name=pmid18318577/>
*[[Sarcomatoid carcinoma]] (spindle cell carcinoma).<ref name=pmid18318577/>
Rare tumours:
*[[Synovial sarcoma]].<ref name=pmid15338724>{{cite journal |author=Llombart-Bosch A, Lopez-Guerrero JA, Peydro-Olaya A |title=Synovial sarcoma (SS): new perspectives supported by modern technology |journal=Arkh. Patol. |volume=64 |issue=3 |pages=39–47 |year=2002 |pmid=15338724 |doi= |url=}}</ref>
*[[Rhabdoid tumour]].<ref name=pmid11557780>{{cite journal |author=Itakura E, Tamiya S, Morita K, ''et al.'' |title=Subcellular distribution of cytokeratin and vimentin in malignant rhabdoid tumor: three-dimensional imaging with confocal laser scanning microscopy and double immunofluorescence |journal=Mod. Pathol. |volume=14 |issue=9 |pages=854–61 |year=2001 |month=September |pmid=11557780 |doi=10.1038/modpathol.3880401 |url=http://www.nature.com/modpathol/journal/v14/n9/full/3880401a.html}}</ref>
*[[Epithelioid sarcoma]].<ref name=pmid10452506>{{cite journal |author=Miettinen M, Fanburg-Smith JC, Virolainen M, Shmookler BM, Fetsch JF |title=Epithelioid sarcoma: an immunohistochemical analysis of 112 classical and variant cases and a discussion of the differential diagnosis |journal=Hum. Pathol. |volume=30 |issue=8 |pages=934–42 |year=1999 |month=August |pmid=10452506 |doi= |url=}}</ref>
*[[Epithelioid angiosarcoma]].<ref name=pmid18318577/>
*[[Desmoplastic small round cell tumour]].<ref name=pmid18318577/>
*[[Anaplastic thyroid carcinoma]].<ref name=pmid18318577/>
*Biphasic [[malignant mesothelioma]].<ref name=pmid18318577/>
*[[Carcinosarcoma]].<ref name=pmid18318577/>
Common tumours that uncommonly have the pattern:
*[[Gastric adenocarcinoma]].<ref>URL: [http://cat.inist.fr/?aModele=afficheN&cpsidt=2504165 http://cat.inist.fr/?aModele=afficheN&cpsidt=2504165]. Accessed on: 26 April 2011.</ref>


==Negative==
==Negative==

Latest revision as of 04:51, 3 August 2016

Vimentin staining in a poorly differentiated carcinoma.
Vimentin staining in a lymphoma.

Vimentin is a common immunostain. It marks most soft tissue lesions and malignant melanoma. It is usually negative in carcinomas.

Positive

Vimentin and cytokeratin positivity

Common tumours:

Rare tumours:

Common tumours that uncommonly have the pattern:

Negative

See also

References

  1. ↑ Mısır, AF.; Durmuşlar, MC.; Zerener, T.; Gün, BD. (Apr 2016). "Primary malignant melanoma.". Saudi Med J 37 (4): 446-9. doi:10.15537/smj.2016.4.15017. PMID 27052289.
  2. ↑ Domagala, W.; Lasota, J.; Chosia, M.; Weber, K.; Osborn, M. (Feb 1989). "Leukocyte-common antigen and vimentin are reliable adjuncts in the diagnosis of non-Hodgkin's lymphoma in fine needle aspirates.". Anal Quant Cytol Histol 11 (1): 15-21. PMID 2524200.
  3. ↑ Gustmann, C.; Altmannsberger, M.; Osborn, M.; Griesser, H.; Feller, AC. (Jun 1991). "Cytokeratin expression and vimentin content in large cell anaplastic lymphomas and other non-Hodgkin's lymphomas.". Am J Pathol 138 (6): 1413-22. PMID 1711289.
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 Bahrami, A.; Truong, LD.; Ro, JY. (Mar 2008). "Undifferentiated tumor: true identity by immunohistochemistry.". Arch Pathol Lab Med 132 (3): 326-48. doi:10.1043/1543-2165(2008)132[326:UTTIBI]2.0.CO;2. PMID 18318577.
  5. ↑ Alkushi, A.; Irving, J.; Hsu, F.; Dupuis, B.; Liu, CL.; Rijn, M.; Gilks, CB. (Mar 2003). "Immunoprofile of cervical and endometrial adenocarcinomas using a tissue microarray.". Virchows Arch 442 (3): 271-7. doi:10.1007/s00428-002-0752-4. PMID 12647218.
  6. ↑ Llombart-Bosch A, Lopez-Guerrero JA, Peydro-Olaya A (2002). "Synovial sarcoma (SS): new perspectives supported by modern technology". Arkh. Patol. 64 (3): 39–47. PMID 15338724.
  7. ↑ Itakura E, Tamiya S, Morita K, et al. (September 2001). "Subcellular distribution of cytokeratin and vimentin in malignant rhabdoid tumor: three-dimensional imaging with confocal laser scanning microscopy and double immunofluorescence". Mod. Pathol. 14 (9): 854–61. doi:10.1038/modpathol.3880401. PMID 11557780. http://www.nature.com/modpathol/journal/v14/n9/full/3880401a.html.
  8. ↑ Miettinen M, Fanburg-Smith JC, Virolainen M, Shmookler BM, Fetsch JF (August 1999). "Epithelioid sarcoma: an immunohistochemical analysis of 112 classical and variant cases and a discussion of the differential diagnosis". Hum. Pathol. 30 (8): 934–42. PMID 10452506.
  9. ↑ URL: http://cat.inist.fr/?aModele=afficheN&cpsidt=2504165. Accessed on: 26 April 2011.
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