Difference between revisions of "Aneurysmal bone cyst"

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#redirect [[Bone#Aneurysmal bone cyst]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Aneurysmal_bone_cyst_-_intermed_mag.jpg
| Width      =
| Caption    = Aneurysmal bone cyst. [[H&E stain]].
| Synonyms  =
| Micro      =
| Subtypes  =
| LMDDx      = [[giant cell tumour of bone]], [[telangiectatic osteosarcoma]], other [[giant cell lesions]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[bone]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = common
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Aneurysmal bone cyst''', abbreviated '''ABC''', is a very common benign pathology of [[bone]].
 
'''[[Giant cell reparative granuloma]]''' (also known as ''solid aneurysmal bone cyst'') is dealt with separately.
 
==General==
Features:<ref name=emed_abc>URL: [http://emedicine.medscape.com/article/1254784-overview http://emedicine.medscape.com/article/1254784-overview]. Accessed on: 4 February 2011.</ref>
*Benign.
**May grow rapidly.
*Osteolysis -> cystic space -> filled with blood.
*Relatively common; in children second only to [[osteosarcoma]].<ref name=pmid18157043>{{cite journal |author=van den Berg H, Kroon HM, Slaar A, Hogendoorn P |title=Incidence of biopsy-proven bone tumors in children: a report based on the Dutch pathology registration "PALGA" |journal=J Pediatr Orthop |volume=28 |issue=1 |pages=29–35 |year=2008 |pmid=18157043 |doi=10.1097/BPO.0b013e3181558cb5 |url=}}</ref>
 
==Gross/radiologic==
Features:<ref name=pmid22531523>{{Cite journal  | last1 = Parashari | first1 = UC. | last2 = Khanduri | first2 = S. | last3 = Upadhyay | first3 = D. | last4 = Bhadury | first4 = S. | last5 = Singhal | first5 = S. | title = Radiologic and pathologic correlation of aneurysmal bone cysts at unusual sites. | journal = J Cancer Res Ther | volume = 8 | issue = 1 | pages = 103-5 | month =  | year =  | doi = 10.4103/0973-1482.95183 | PMID = 22531523 }}</ref>
*Air-fluid levels (radiology).
*Usually metaphysis of long bones, but uncommonly the femur.
*May have an "aggressive" appearance, i.e. erode bone.
 
==Microscopic==
Features:<ref name=emed_abc/>
*Bony trabeculae ''or'' osteoid tissue.
*Osteoclast [[giant cell]]s.
**Multi-nucleated giant-cells with round randomly arranged nuclei.
*Benign spindle cells (fibroblasts) - surround bone/adjacent to the giant cells - '''important'''.
*Blood +/- surrounded by giant cells.
 
DDx:
*[[Giant cell tumour of bone]] - the nuclei of the cells surrounding the giant cells are similar to those in the giant cells (round nuclei).
*[[Telangiectatic osteosarcoma]].
*Other [[giant cell lesions]].
 
===Images===
<gallery>
Image:Aneurysmal_bone_cyst_-_intermed_mag.jpg | ABC - intermed. mag. (WC/Nephron)
Image:Aneurysmal_bone_cyst_-_high_mag.jpg | ABC - high mag. (WC/Nephron)
Image:Aneurysmal_bone_cyst_-_very_high_mag.jpg | ABC - very high mag. (WC/Nephron)
Image:[[File:Bone AneurysmalBoneCyst HP.JPG|thumb|High power view of giant cells in a less cellular version of aneurysmal bone cyst.]]
</gallery>
www:
*[http://www.webpathology.com/image.asp?n=4&Case=344 ABC - low mag. (webpathology.com)].
*[http://www.webpathology.com/image.asp?n=5&Case=344 ABC - intermed. mag. (webpathology.com)].
*[http://www.webpathology.com/image.asp?case=344&n=6 ABC - high mag. (webpathology.com)].
 
==See also==
*[[Bone]].
 
==References==
{{Reflist|2}}
 
[[Category:Bone]]
[[Category:Diagnosis]]

Latest revision as of 02:47, 3 December 2014

Aneurysmal bone cyst
Diagnosis in short

Aneurysmal bone cyst. H&E stain.
LM DDx giant cell tumour of bone, telangiectatic osteosarcoma, other giant cell lesions
Site bone
Prevalence common
Prognosis benign

Aneurysmal bone cyst, abbreviated ABC, is a very common benign pathology of bone.

Giant cell reparative granuloma (also known as solid aneurysmal bone cyst) is dealt with separately.

General

Features:[1]

  • Benign.
    • May grow rapidly.
  • Osteolysis -> cystic space -> filled with blood.
  • Relatively common; in children second only to osteosarcoma.[2]

Gross/radiologic

Features:[3]

  • Air-fluid levels (radiology).
  • Usually metaphysis of long bones, but uncommonly the femur.
  • May have an "aggressive" appearance, i.e. erode bone.

Microscopic

Features:[1]

  • Bony trabeculae or osteoid tissue.
  • Osteoclast giant cells.
    • Multi-nucleated giant-cells with round randomly arranged nuclei.
  • Benign spindle cells (fibroblasts) - surround bone/adjacent to the giant cells - important.
  • Blood +/- surrounded by giant cells.

DDx:

Images

  • ABC - intermed. mag. (WC/Nephron)

  • ABC - high mag. (WC/Nephron)

  • ABC - very high mag. (WC/Nephron)

www:

See also

References

  1. ↑ 1.0 1.1 URL: http://emedicine.medscape.com/article/1254784-overview. Accessed on: 4 February 2011.
  2. ↑ van den Berg H, Kroon HM, Slaar A, Hogendoorn P (2008). "Incidence of biopsy-proven bone tumors in children: a report based on the Dutch pathology registration "PALGA"". J Pediatr Orthop 28 (1): 29–35. doi:10.1097/BPO.0b013e3181558cb5. PMID 18157043.
  3. ↑ Parashari, UC.; Khanduri, S.; Upadhyay, D.; Bhadury, S.; Singhal, S.. "Radiologic and pathologic correlation of aneurysmal bone cysts at unusual sites.". J Cancer Res Ther 8 (1): 103-5. doi:10.4103/0973-1482.95183. PMID 22531523.
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