Difference between revisions of "Keratinising squamous metaplasia of the urinary bladder"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Keratinizing squamous metaplasia of the bladder -- low mag.jpg | |||
| Width = | |||
| Caption = Keratinizing squamous metaplasia of the bladder. [[H&E stain]]. (WC/Nephron) | |||
| Synonyms = | |||
| Micro = squamous epithelium with hyperkeratosis or parakeratosis, negative for atypia | |||
| Subtypes = | |||
| LMDDx = [[squamous dysplasia]] of the metaplastic epithelium, [[squamous cell carcinoma of the urinary bladder]], metastatic [[squamous cell carcinoma]], [[urothelial carcinoma]] with squamous metaplasia or squamous differentiation | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = [[urinary bladder]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = usually males (males:females = 4:1) | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign, increased risk of malignancy | |||
| Other = | |||
| ClinDDx = | |||
| Tx = clinical follow-up | |||
}} | |||
'''Keratinising squamous metaplasia of the urinary bladder''' is a rare benign change of the [[urinary bladder]] associated with an increased risk of [[malignancy]];<ref name=pmid12429156>{{Cite journal | last1 = Khan | first1 = MS. | last2 = Thornhill | first2 = JA. | last3 = Gaffney | first3 = E. | last4 = Loftus | first4 = B. | last5 = Butler | first5 = MR. | title = Keratinising squamous metaplasia of the bladder: natural history and rationalization of management based on review of 54 years experience. | journal = Eur Urol | volume = 42 | issue = 5 | pages = 469-74 | month = Nov | year = 2002 | doi = | PMID = 12429156 }}</ref> however, it is not considered a pre-malignant condition.<ref name=pmid1379440>{{Cite journal | last1 = Kvist | first1 = E. | last2 = Sjølin | first2 = KE. | last3 = Laursen | first3 = H. | last4 = Orntoft | first4 = TF. | last5 = Sturmer | first5 = MA. | title = Squamous cell metaplasia of the bladder urothelium. A retrospective study of 36 patients. | journal = APMIS | volume = 100 | issue = 7 | pages = 650-4 | month = Jul | year = 1992 | doi = | PMID = 1379440 }}</ref><ref name=pmid18931537>{{Cite journal | last1 = Ahmad | first1 = I. | last2 = Barnetson | first2 = RJ. | last3 = Krishna | first3 = NS. | title = Keratinizing squamous metaplasia of the bladder: a review. | journal = Urol Int | volume = 81 | issue = 3 | pages = 247-51 | month = | year = 2008 | doi = 10.1159/000151398 | PMID = 18931537 }}</ref> | '''Keratinising squamous metaplasia of the urinary bladder''' is a rare benign change of the [[urinary bladder]] associated with an increased risk of [[malignancy]];<ref name=pmid12429156>{{Cite journal | last1 = Khan | first1 = MS. | last2 = Thornhill | first2 = JA. | last3 = Gaffney | first3 = E. | last4 = Loftus | first4 = B. | last5 = Butler | first5 = MR. | title = Keratinising squamous metaplasia of the bladder: natural history and rationalization of management based on review of 54 years experience. | journal = Eur Urol | volume = 42 | issue = 5 | pages = 469-74 | month = Nov | year = 2002 | doi = | PMID = 12429156 }}</ref> however, it is not considered a pre-malignant condition.<ref name=pmid1379440>{{Cite journal | last1 = Kvist | first1 = E. | last2 = Sjølin | first2 = KE. | last3 = Laursen | first3 = H. | last4 = Orntoft | first4 = TF. | last5 = Sturmer | first5 = MA. | title = Squamous cell metaplasia of the bladder urothelium. A retrospective study of 36 patients. | journal = APMIS | volume = 100 | issue = 7 | pages = 650-4 | month = Jul | year = 1992 | doi = | PMID = 1379440 }}</ref><ref name=pmid18931537>{{Cite journal | last1 = Ahmad | first1 = I. | last2 = Barnetson | first2 = RJ. | last3 = Krishna | first3 = NS. | title = Keratinizing squamous metaplasia of the bladder: a review. | journal = Urol Int | volume = 81 | issue = 3 | pages = 247-51 | month = | year = 2008 | doi = 10.1159/000151398 | PMID = 18931537 }}</ref> | ||
''Urinary bladder with squamous metaplasia'' and ''squamous metaplasia of the urinary bladder'' redirect to this article. | |||
==General== | ==General== | ||
*Rare.<ref name=pmid18931537/> | *Rare.<ref name=pmid18931537/> ‡ | ||
*Large age range (13-80 years).<ref name=pmid12429156/> | *Large age range (13-80 years).<ref name=pmid12429156/> | ||
*Predominantly males - almost 4:1 (27 males:7 females in one series<ref name=pmid12429156/>). | *Predominantly males - almost 4:1 (27 males:7 females in one series<ref name=pmid12429156/>). | ||
Treatment: | Treatment: | ||
*Follow-up is recommended.<ref name=pmid18931537/> | *Follow-up is recommended.<ref name=pmid18931537/><ref>{{cite journal |authors=Benelli A, Varca V, Vaccaro C, Guzzo S, Nicola M, Onorati M, Gregori A, Di Nuovo F |title=Keratinizing squamous metaplasia of the bladder: Our experience and current approaches |journal=Urologia |volume=87 |issue=2 |pages=97–100 |date=May 2020 |pmid=30509153 |doi=10.1177/0391560318810197 |url=}}</ref> | ||
Note: | |||
*‡ Non-keratinizing squamous metaplasia can be considered normal and is relatively common in the trigone region of the bladder in women.{{fact}} | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*Squamous epithelium with hyperkeratosis or parakeratosis. | *Squamous epithelium with hyperkeratosis or parakeratosis. | ||
*Negative for significant [[nuclear atypia]]. | |||
DDx: | DDx: | ||
| Line 18: | Line 55: | ||
*[[Squamous cell carcinoma of the urinary bladder]]. | *[[Squamous cell carcinoma of the urinary bladder]]. | ||
*Metastatic [[squamous cell carcinoma]], e.g. [[squamous cell carcinoma of the uterine cervix]]. | *Metastatic [[squamous cell carcinoma]], e.g. [[squamous cell carcinoma of the uterine cervix]]. | ||
*[[Urothelial carcinoma]] with squamous metaplasia. | *[[Urothelial carcinoma]] with squamous metaplasia or squamous differentiation. | ||
==Sign out== | ==Sign out== | ||
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Comment: | Comment: | ||
Regular follow-up is recommended. | Regular follow-up is recommended.[1,2] | ||
1. Urol Int 81 (3): 247-51. doi:10.1159/000151398. PMID 18931537. | |||
2. Urologia 87 (2): 97–100. doi:10.1177/0391560318810197. PMID 30509153. | |||
</pre> | </pre> | ||
Latest revision as of 13:58, 25 May 2023
| Keratinising squamous metaplasia of the urinary bladder | |
|---|---|
| Diagnosis in short | |
 Keratinizing squamous metaplasia of the bladder. H&E stain. (WC/Nephron) | |
|
| |
| LM | squamous epithelium with hyperkeratosis or parakeratosis, negative for atypia |
| LM DDx | squamous dysplasia of the metaplastic epithelium, squamous cell carcinoma of the urinary bladder, metastatic squamous cell carcinoma, urothelial carcinoma with squamous metaplasia or squamous differentiation |
| Site | urinary bladder |
|
| |
| Clinical history | usually males (males:females = 4:1) |
| Prevalence | rare |
| Prognosis | benign, increased risk of malignancy |
| Treatment | clinical follow-up |
Keratinising squamous metaplasia of the urinary bladder is a rare benign change of the urinary bladder associated with an increased risk of malignancy;[1] however, it is not considered a pre-malignant condition.[2][3]
Urinary bladder with squamous metaplasia and squamous metaplasia of the urinary bladder redirect to this article.
General
- Rare.[3] ‡
- Large age range (13-80 years).[1]
- Predominantly males - almost 4:1 (27 males:7 females in one series[1]).
Treatment:
Note:
- ‡ Non-keratinizing squamous metaplasia can be considered normal and is relatively common in the trigone region of the bladder in women.[citation needed]
Microscopic
Features:
- Squamous epithelium with hyperkeratosis or parakeratosis.
- Negative for significant nuclear atypia.
DDx:
- Squamous dysplasia of the metaplastic epithelium.
- Squamous cell carcinoma of the urinary bladder.
- Metastatic squamous cell carcinoma, e.g. squamous cell carcinoma of the uterine cervix.
- Urothelial carcinoma with squamous metaplasia or squamous differentiation.
Sign out
Urinary Bladder Lesion, Biopsy: - Extensive keratinizing squamous metaplasia with degenerative changes and acute and chronic inflammation. - NEGATIVE for dysplasia and NEGATIVE for malignancy. Comment: Regular follow-up is recommended.[1,2] 1. Urol Int 81 (3): 247-51. doi:10.1159/000151398. PMID 18931537. 2. Urologia 87 (2): 97–100. doi:10.1177/0391560318810197. PMID 30509153.
See also
References
- ↑ 1.0 1.1 1.2 Khan, MS.; Thornhill, JA.; Gaffney, E.; Loftus, B.; Butler, MR. (Nov 2002). "Keratinising squamous metaplasia of the bladder: natural history and rationalization of management based on review of 54 years experience.". Eur Urol 42 (5): 469-74. PMID 12429156.
- ↑ Kvist, E.; Sjølin, KE.; Laursen, H.; Orntoft, TF.; Sturmer, MA. (Jul 1992). "Squamous cell metaplasia of the bladder urothelium. A retrospective study of 36 patients.". APMIS 100 (7): 650-4. PMID 1379440.
- ↑ 3.0 3.1 3.2 Ahmad, I.; Barnetson, RJ.; Krishna, NS. (2008). "Keratinizing squamous metaplasia of the bladder: a review.". Urol Int 81 (3): 247-51. doi:10.1159/000151398. PMID 18931537.
- ↑ Benelli A, Varca V, Vaccaro C, Guzzo S, Nicola M, Onorati M, Gregori A, Di Nuovo F (May 2020). "Keratinizing squamous metaplasia of the bladder: Our experience and current approaches". Urologia 87 (2): 97–100. doi:10.1177/0391560318810197. PMID 30509153.