Brenner tumour: Difference between revisions
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| Micro = nests cells that have a "[[coffee bean nucleus]]" (nucleus = elliptical shape, nuclear groove along long axis), distinct nucleoli, moderate-to-abundant gray/pale cytoplasm, dense fibrous stroma around nests | | Micro = nests cells that have a "[[coffee bean nucleus]]" (nucleus = elliptical shape, nuclear groove along long axis), distinct nucleoli, moderate-to-abundant gray/pale cytoplasm, dense fibrous stroma around nests | ||
| Subtypes = benign (most common), borderline, malignant | | Subtypes = benign (most common), borderline, malignant | ||
| LMDDx = [[granulosa cell tumour]], [[ovarian fibroma]], [[thecoma]] | | LMDDx = [[granulosa cell tumour]], [[ovarian fibroma]], [[thecoma]], [[Walthard cell rest]] | ||
| Stains = | | Stains = | ||
| IHC = AR +ve, calretinin -ve | | IHC = AR +ve, calretinin -ve | ||
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*Main DDx of Coffee bean nucleus = [[granulosa cell tumour]]. | *Main DDx of Coffee bean nucleus = [[granulosa cell tumour]]. | ||
*Stromal component may be predominant. | *Stromal component may be predominant. | ||
Subclassification: | |||
*Benign. | |||
*Borderline. | |||
*Malignant <5% of tumour.<ref>{{cite journal |authors=Zhang Y, Staley SA, Tucker K, Clark LH |title=Malignant Brenner tumor of the ovary: Case series and review of treatment strategies |journal=Gynecol Oncol Rep |volume=28 |issue= |pages=29–32 |date=May 2019 |pmid=30815527 |pmc=6378317 |doi=10.1016/j.gore.2019.02.003 |url=}}</ref> | |||
DDx:<ref name=Ref_GP437>{{Ref GP|437}}</ref> | DDx:<ref name=Ref_GP437>{{Ref GP|437}}</ref> | ||
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**Serous carcinoma. | **Serous carcinoma. | ||
**Metastatic urothelial carcinoma. | **Metastatic urothelial carcinoma. | ||
*[[Walthard cell rest]] - typically one nest of cells, | *[[Walthard cell rest]] - typically one nest of cells, lacks the surrounding fibromatous stroma. | ||
===Images=== | ===Images=== | ||