Difference between revisions of "Medial calcific sclerosis"
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Medial calcific sclerosis -- intermed mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Medial calcific sclerosis. [[H&E stain]]. | ||
| Synonyms = Moenckeberg medial calcific sclerosis, calcific medial sclerosis of Monckeberg, Mönckeberg's arteriosclerosis (also written ''Monckeberg's arteriosclerosis'') | | Synonyms = Moenckeberg medial calcific sclerosis, calcific medial sclerosis of Monckeberg, Mönckeberg's arteriosclerosis (also written ''Monckeberg's arteriosclerosis'') | ||
| Micro = calcifications of the tunica media | | Micro = calcifications of the tunica media | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = [[atherosclerosis]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
| Line 16: | Line 16: | ||
| Grossing = | | Grossing = | ||
| Staging = | | Staging = | ||
| Site = | | Site = [[blood vessels]] - arteries | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
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==General== | ==General== | ||
*Usually of no clinical consequence. | *Usually of no clinical consequence. | ||
*May impact vascular assessments using ultrasound.<ref>{{cite journal |authors=Suludere MA, Danesh SK, Killeen AL, Crisologo PA, Malone M, Siah MC, Lavery LA |title=Mönckeberg's Medial Calcific Sclerosis Makes Traditional Arterial Doppler's Unreliable in High-Risk Patients with Diabetes |journal=Int J Low Extrem Wounds |volume= |issue= |pages=15347346231191588 |date=July 2023 |pmid=37525549 |doi=10.1177/15347346231191588 |url=}}</ref> | |||
==Microscopic== | ==Microscopic== | ||
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Note: | Note: | ||
*Lumen unaffected. | *Lumen unaffected. | ||
*It has been suggested that it usually involves the ''internal elastic lamina''.<ref>{{cite journal |authors=Micheletti RG, Fishbein GA, Currier JS, Fishbein MC |title=Mönckeberg sclerosis revisited: a clarification of the histologic definition of Mönckeberg sclerosis |journal=Arch Pathol Lab Med |volume=132 |issue=1 |pages=43–7 |date=January 2008 |pmid=18181672 |doi=10.5858/2008-132-43-MSRACO |url=}}</ref> | |||
DDx:<ref>{{cite journal |authors=Dos Santos VP, Pozzan G, Castelli V, Caffaro RA |title=Arteriosclerosis, atherosclerosis, arteriolosclerosis, and Monckeberg medial calcific sclerosis: what is the difference? |journal=J Vasc Bras |volume=20 |issue= |pages=e20200211 |date=2021 |pmid=34290756 |pmc=8276643 |doi=10.1590/1677-5449.200211 |url=}}</ref> | |||
*[[Atherosclerosis]] (severe) - intimal hyperplasia with stenosis, calcifications typically in tunica intima. | |||
===Images=== | ===Images=== | ||
<gallery> | |||
Image: Medial calcific sclerosis -- low mag.jpg | MCS - low mag. (WC) | |||
Image: Medial calcific sclerosis -- intermed mag.jpg | MCS - intermed. mag. (WC) | |||
Image: Medial calcific sclerosis -- high mag.jpg | MCS - high mag. (WC) | |||
Image: Medial calcific sclerosis - alt -- intermed mag.jpg | MCS - intermed. mag. (WC) | |||
Image: Medial calcific sclerosis - alt -- high mag.jpg | MCS - high mag. (WC) | |||
</gallery> | |||
<gallery> | <gallery> | ||
Image:Calcificatio_atherosclerotica.jpg | MCS. (WC) | Image:Calcificatio_atherosclerotica.jpg | MCS. (WC) | ||
</gallery> | </gallery> | ||
==Sign out== | ==Sign out== | ||
| Line 62: | Line 73: | ||
The sections may not be representative of disease in the distal vascular bed. | The sections may not be representative of disease in the distal vascular bed. | ||
</pre> | </pre> | ||
==See also== | ==See also== | ||
Latest revision as of 20:49, 30 April 2025
Medial calcific sclerosis is a type of arteriosclerosis that has no significant clinical impact.
| Medial calcific sclerosis | |
|---|---|
| Diagnosis in short | |
 Medial calcific sclerosis. H&E stain. | |
|
| |
| Synonyms | Moenckeberg medial calcific sclerosis, calcific medial sclerosis of Monckeberg, Mönckeberg's arteriosclerosis (also written Monckeberg's arteriosclerosis) |
|
| |
| LM | calcifications of the tunica media |
| LM DDx | atherosclerosis |
| Site | blood vessels - arteries |
|
| |
| Prognosis | good |
| Treatment | (nothing) |
It is also known as Moenckeberg medial calcific sclerosis, calcific medial sclerosis of Monckeberg, and Mönckeberg's arteriosclerosis (also written Monckeberg's arteriosclerosis).
General
- Usually of no clinical consequence.
- May impact vascular assessments using ultrasound.[1]
Microscopic
Features:[2]
- Medial calcification (purple irregular stuff on H&E -- calcium phosphate).
Note:
- Lumen unaffected.
- It has been suggested that it usually involves the internal elastic lamina.[3]
DDx:[4]
- Atherosclerosis (severe) - intimal hyperplasia with stenosis, calcifications typically in tunica intima.
Images
MCS - low mag. (WC)
MCS - intermed. mag. (WC)
MCS - high mag. (WC)
MCS - intermed. mag. (WC)
MCS - high mag. (WC)
MCS. (WC)
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RIGHT LEG, BELOW KNEE AMPUTATION: - MINIMAL-TO-MILD LARGE VESSEL ATHEROSCLEROSIS, SEE COMMENT. - MEDIAL CALCIFIC SCLEROSIS. - SKIN WITH DERMAL FIBROSIS. COMMENT: The sections may not be representative of disease in the distal vascular bed.
See also
References
- ↑ Suludere MA, Danesh SK, Killeen AL, Crisologo PA, Malone M, Siah MC, Lavery LA (July 2023). "Mönckeberg's Medial Calcific Sclerosis Makes Traditional Arterial Doppler's Unreliable in High-Risk Patients with Diabetes". Int J Low Extrem Wounds: 15347346231191588. doi:10.1177/15347346231191588. PMID 37525549.
- ↑ Klatt, Edward C. (2006). Robbins and Cotran Atlas of Pathology (1st ed.). Saunders. pp. 7. ISBN 978-1416002741.
- ↑ Micheletti RG, Fishbein GA, Currier JS, Fishbein MC (January 2008). "Mönckeberg sclerosis revisited: a clarification of the histologic definition of Mönckeberg sclerosis". Arch Pathol Lab Med 132 (1): 43–7. doi:10.5858/2008-132-43-MSRACO. PMID 18181672.
- ↑ Dos Santos VP, Pozzan G, Castelli V, Caffaro RA (2021). "Arteriosclerosis, atherosclerosis, arteriolosclerosis, and Monckeberg medial calcific sclerosis: what is the difference?". J Vasc Bras 20: e20200211. doi:10.1590/1677-5449.200211. PMC 8276643. PMID 34290756. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276643/.