Difference between revisions of "Psammoma bodies"

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[[Image:Serous carcinoma - omentum -- very high mag.jpg|200px|thumb|Psammoma bodies in [[serous carcinoma]]. [[H&E stain]].]]
[[Image:Serous carcinoma - omentum -- very high mag.jpg|300px|thumb|Psammoma bodies in [[serous carcinoma]]. [[H&E stain]].]]
[[Image:Meningioma showing Psammoma body.jpg|200px|thumb|Psammoma bodies in [[meningioma]]. [[H&E stain]].]]
[[Image:Meningioma showing Psammoma body.jpg|300px|thumb|Psammoma bodies in [[meningioma]]. [[H&E stain]].]]
'''Psammoma bodies''' appear in benign and malignant conditions.  Their presence can help focus the DDx.<ref>{{Cite journal  | last1 = Parwani | first1 = AV. | last2 = Chan | first2 = TY. | last3 = Ali | first3 = SZ. | title = Significance of psammoma bodies in serous cavity fluid: a cytopathologic analysis. | journal = Cancer | volume = 102 | issue = 2 | pages = 87-91 | month = Apr | year = 2004 | doi = 10.1002/cncr.20161 | PMID = 15098252 | URL = http://onlinelibrary.wiley.com/doi/10.1002/cncr.20161/full}}</ref>  
'''Psammoma bodies''' appear in benign and malignant conditions.  Their presence can help focus the DDx.<ref>{{Cite journal  | last1 = Parwani | first1 = AV. | last2 = Chan | first2 = TY. | last3 = Ali | first3 = SZ. | title = Significance of psammoma bodies in serous cavity fluid: a cytopathologic analysis. | journal = Cancer | volume = 102 | issue = 2 | pages = 87-91 | month = Apr | year = 2004 | doi = 10.1002/cncr.20161 | PMID = 15098252 | URL = http://onlinelibrary.wiley.com/doi/10.1002/cncr.20161/full}}</ref>  


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===Benign===
===Benign===
*[[Endosalpingiosis]].
*[[Endosalpingiosis]].
*[[Endometriosis]].<ref name=pmid8725135>{{Cite journal  | last1 = Minkowitz | first1 = G. | title = Psammoma bodies in endometriosis: clinical, cytological, and physiopathological implications. | journal = Diagn Cytopathol | volume = 14 | issue = 4 | pages = 331-3 | month = Jun | year = 1996 | doi = 10.1002/(SICI)1097-0339(199605)14:4<331::AID-DC11>3.0.CO;2-L | PMID = 8725135 }}</ref><ref name=pmid15098252>{{Cite journal  | last1 = Parwani | first1 = AV. | last2 = Chan | first2 = TY. | last3 = Ali | first3 = SZ. | title = Significance of psammoma bodies in serous cavity fluid: a cytopathologic analysis. | journal = Cancer | volume = 102 | issue = 2 | pages = 87-91 | month = Apr | year = 2004 | doi = 10.1002/cncr.20161 | PMID = 15098252 }}</ref>
*[[Intrauterine device]] (IUD).<ref name=pmid12278909>{{Cite journal  | last1 = Boon | first1 = ME. | last2 = Kirk | first2 = RS. | last3 = De Graaff Guilloud | first3 = JC. | title = Psammoma bodies and some opportunistic infections detected in cervical smears of women fitted with an IUD. | journal = Contracept Deliv Syst | volume = 2 | issue = 3 | pages = 231-6 | month = Jul | year = 1981 | doi =  | PMID = 12278909 }}</ref>
*[[Intrauterine device]] (IUD).<ref name=pmid12278909>{{Cite journal  | last1 = Boon | first1 = ME. | last2 = Kirk | first2 = RS. | last3 = De Graaff Guilloud | first3 = JC. | title = Psammoma bodies and some opportunistic infections detected in cervical smears of women fitted with an IUD. | journal = Contracept Deliv Syst | volume = 2 | issue = 3 | pages = 231-6 | month = Jul | year = 1981 | doi =  | PMID = 12278909 }}</ref>
*[[Endometrial polyp]].<ref name=pmid11854631>{{cite journal |author=Fausett MB, Zahn CM, Kendall BS, Barth WH |title=The significance of psammoma bodies that are found incidentally during endometrial biopsy |journal=Am. J. Obstet. Gynecol. |volume=186 |issue=2 |pages=180–3 |year=2002 |month=February |pmid=11854631 |doi= |url=}}</ref>
*[[Endometrial polyp]].<ref name=pmid11854631>{{cite journal |author=Fausett MB, Zahn CM, Kendall BS, Barth WH |title=The significance of psammoma bodies that are found incidentally during endometrial biopsy |journal=Am. J. Obstet. Gynecol. |volume=186 |issue=2 |pages=180–3 |year=2002 |month=February |pmid=11854631 |doi= |url=}}</ref>
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*Anaplastic [[Meningioma]].<ref>{{Cite journal  | last1 = KEPES | first1 = J. | title = Observations on the formation of psammoma bodies and pseudopsammoma bodies in meningiomas. | journal = J Neuropathol Exp Neurol | volume = 20 | issue =  | pages = 255-62 | month = Apr | year = 1961 | doi =  | PMID = 13752577 }}</ref>
*Anaplastic [[Meningioma]].<ref>{{Cite journal  | last1 = KEPES | first1 = J. | title = Observations on the formation of psammoma bodies and pseudopsammoma bodies in meningiomas. | journal = J Neuropathol Exp Neurol | volume = 20 | issue =  | pages = 255-62 | month = Apr | year = 1961 | doi =  | PMID = 13752577 }}</ref>
*[[Mesothelioma]].
*[[Mesothelioma]].
*[[Biphasic hyalinizing psammomatous renal cell carcinoma]].


Memory device ''PSaMMoma'': '''P'''apillary (thyroid, renal), '''S'''erous (ovary), '''M'''eningioma, '''M'''esothelioma.<ref>URL: [http://ome.umaryland.edu/AcademicD/practiceExams/path/path_findings.html http://ome.umaryland.edu/AcademicD/practiceExams/path/path_findings.html]. Accessed on: 15 January 2012.</ref>
Memory device for common tumours ''PSaMMoma'': '''P'''apillary (thyroid, renal), '''S'''erous (ovary), '''M'''eningioma, '''M'''esothelioma.<ref>URL: [http://ome.umaryland.edu/AcademicD/practiceExams/path/path_findings.html http://ome.umaryland.edu/AcademicD/practiceExams/path/path_findings.html]. Accessed on: 15 January 2012.</ref>


Isolated psammoma bodies in smears or aspirates are an unreliable predictor of papillary carcinoma. <ref>{{Cite journal  | last1 = Ellison | first1 = E. | last2 = Lapuerta | first2 = P. | last3 = Martin | first3 = SE. | title = Psammoma bodies in fine-needle aspirates of the thyroid: predictive value for papillary carcinoma. | journal = Cancer | volume = 84 | issue = 3 | pages = 169-75 | month = Jun | year = 1998 | doi =  | PMID = 9678732 }}</ref>
Isolated psammoma bodies in smears or aspirates are an unreliable predictor of papillary carcinoma. <ref>{{Cite journal  | last1 = Ellison | first1 = E. | last2 = Lapuerta | first2 = P. | last3 = Martin | first3 = SE. | title = Psammoma bodies in fine-needle aspirates of the thyroid: predictive value for papillary carcinoma. | journal = Cancer | volume = 84 | issue = 3 | pages = 169-75 | month = Jun | year = 1998 | doi =  | PMID = 9678732 }}</ref>

Latest revision as of 05:14, 13 October 2021

Psammoma bodies in serous carcinoma. H&E stain.
Psammoma bodies in meningioma. H&E stain.

Psammoma bodies appear in benign and malignant conditions. Their presence can help focus the DDx.[1]

They are often associated with a papillary architecture.[citation needed]

Conditions with psammoma bodies

The following is an incomplete list.

Benign

Malignant

Memory device for common tumours PSaMMoma: Papillary (thyroid, renal), Serous (ovary), Meningioma, Mesothelioma.[11]

Isolated psammoma bodies in smears or aspirates are an unreliable predictor of papillary carcinoma. [12]

See also

References

  1. Parwani, AV.; Chan, TY.; Ali, SZ. (Apr 2004). "Significance of psammoma bodies in serous cavity fluid: a cytopathologic analysis.". Cancer 102 (2): 87-91. doi:10.1002/cncr.20161. PMID 15098252.
  2. Minkowitz, G. (Jun 1996). "Psammoma bodies in endometriosis: clinical, cytological, and physiopathological implications.". Diagn Cytopathol 14 (4): 331-3. doi:10.1002/(SICI)1097-0339(199605)14:4<331::AID-DC11>3.0.CO;2-L. PMID 8725135.
  3. Parwani, AV.; Chan, TY.; Ali, SZ. (Apr 2004). "Significance of psammoma bodies in serous cavity fluid: a cytopathologic analysis.". Cancer 102 (2): 87-91. doi:10.1002/cncr.20161. PMID 15098252.
  4. Boon, ME.; Kirk, RS.; De Graaff Guilloud, JC. (Jul 1981). "Psammoma bodies and some opportunistic infections detected in cervical smears of women fitted with an IUD.". Contracept Deliv Syst 2 (3): 231-6. PMID 12278909.
  5. Fausett MB, Zahn CM, Kendall BS, Barth WH (February 2002). "The significance of psammoma bodies that are found incidentally during endometrial biopsy". Am. J. Obstet. Gynecol. 186 (2): 180–3. PMID 11854631.
  6. KEPES, J. (Apr 1961). "Observations on the formation of psammoma bodies and pseudopsammoma bodies in meningiomas.". J Neuropathol Exp Neurol 20: 255-62. PMID 13752577.
  7. Wolfson, WL.; Rosenthal, DL.; Harney, B.. "Psammoma bodies in pituitary adenoma.". Acta Cytol 23 (1): 90-2. PMID 285558.
  8. Jovanović, I.; Ugrenović, S.; Vasović, L.; Petrović, D.; Cekić, S. (Jun 2010). "Psammoma bodies - friends or foes of the aging choroid plexus.". Med Hypotheses 74 (6): 1017-20. doi:10.1016/j.mehy.2010.01.006. PMID 20116930.
  9. Kim, JA.; Choi, WH.; Kim, CN.; Moon, YS.; Chang, SH.; Lee, HR. (Mar 2011). "Duodenal somatostatinoma: a case report and review.". Korean J Intern Med 26 (1): 103-7. doi:10.3904/kjim.2011.26.1.103. PMID 21437171.
  10. KEPES, J. (Apr 1961). "Observations on the formation of psammoma bodies and pseudopsammoma bodies in meningiomas.". J Neuropathol Exp Neurol 20: 255-62. PMID 13752577.
  11. URL: http://ome.umaryland.edu/AcademicD/practiceExams/path/path_findings.html. Accessed on: 15 January 2012.
  12. Ellison, E.; Lapuerta, P.; Martin, SE. (Jun 1998). "Psammoma bodies in fine-needle aspirates of the thyroid: predictive value for papillary carcinoma.". Cancer 84 (3): 169-75. PMID 9678732.