Difference between revisions of "Xanthogranulomatous cystitis"
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'''Xanthogranulomatous cystitis''' is an uncommon | '''Xanthogranulomatous cystitis''' is an uncommon chronic form of [[cystitis]] that may mimic [[malignancy]]. | ||
==General== | ==General== | ||
*May mimic [[malignancy]].<ref name=pmid25550882>{{Cite journal | last1 = Wang | first1 = Y. | last2 = Han | first2 = XC. | last3 = Zheng | first3 = LQ. | last4 = Miao | first4 = WL. | title = Xanthogranulomatous cystitis imitating bladder neoplasm: a case report and review of literature. | journal = Int J Clin Exp Pathol | volume = 7 | issue = 11 | pages = 8255-8 | month = | year = 2014 | doi = | PMID = 25550882 }}</ref> | *May mimic [[malignancy]].<ref name=pmid25550882>{{Cite journal | last1 = Wang | first1 = Y. | last2 = Han | first2 = XC. | last3 = Zheng | first3 = LQ. | last4 = Miao | first4 = WL. | title = Xanthogranulomatous cystitis imitating bladder neoplasm: a case report and review of literature. | journal = Int J Clin Exp Pathol | volume = 7 | issue = 11 | pages = 8255-8 | month = | year = 2014 | doi = | PMID = 25550882 }}</ref><ref name=pmid25371622>{{Cite journal | last1 = Ali | first1 = AM. | last2 = Nelvigi | first2 = GG. | last3 = Keshavaiah | first3 = VG. | last4 = Ratkal | first4 = CS. | title = Extensive xanthogranulomatous cystitis mimicking bladder cancer. | journal = Urol Ann | volume = 6 | issue = 4 | pages = 373-5 | month = Oct | year = 2014 | doi = 10.4103/0974-7796.141018 | PMID = 25371622 }}</ref> | ||
Clinical features - generally nonspecific:<ref>{{Cite journal | last1 = Grivas | first1 = N. | title = Challenges in the diagnosis of xanthogranulomatous cystitis. | journal = Urol Ann | volume = 6 | issue = 4 | pages = 375-6 | month = Oct | year = 2014 | doi = 10.4103/0974-7796.141019 | PMID = 25371623 }}</ref> | |||
*Dysuria (pain on urination). | |||
*+/-Hematuria. | |||
*Often history of [[renal stones]] or recurrent [[UTI]]s. | |||
==Gross== | |||
*Typically dome of [[urinary bladder]] (18 of 27 cases).<ref name=pmid25371622>{{Cite journal | last1 = Ali | first1 = AM. | last2 = Nelvigi | first2 = GG. | last3 = Keshavaiah | first3 = VG. | last4 = Ratkal | first4 = CS. | title = Extensive xanthogranulomatous cystitis mimicking bladder cancer. | journal = Urol Ann | volume = 6 | issue = 4 | pages = 373-5 | month = Oct | year = 2014 | doi = 10.4103/0974-7796.141018 | PMID = 25371622 }}</ref> | |||
==Microscopic== | |||
Features: | |||
*Foamy macrophages. | |||
*Chronic inflammatory cells - typically lymphocytes and plasma cells. | |||
*+/-Cholesterol clefts. | |||
DDx: | |||
*[[Urinary bladder xanthoma]]. | |||
*[[Malakoplakia]]. | |||
*[[Signet ring cell carcinoma]]. | |||
==IHC== | ==IHC== | ||
| Line 11: | Line 30: | ||
==See also== | ==See also== | ||
*[[Xanthogranulomatous pyelonephritis]]. | *[[Xanthogranulomatous pyelonephritis]]. | ||
*[[Granulomatous inflammation]]. | |||
==References== | ==References== | ||
{{Reflist| | {{Reflist|2}} | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Urinary bladder]] | [[Category:Urinary bladder]] | ||
Latest revision as of 23:46, 22 July 2015
Xanthogranulomatous cystitis is an uncommon chronic form of cystitis that may mimic malignancy.
General
- May mimic malignancy.[1][2]
Clinical features - generally nonspecific:[3]
- Dysuria (pain on urination).
- +/-Hematuria.
- Often history of renal stones or recurrent UTIs.
Gross
- Typically dome of urinary bladder (18 of 27 cases).[2]
Microscopic
Features:
- Foamy macrophages.
- Chronic inflammatory cells - typically lymphocytes and plasma cells.
- +/-Cholesterol clefts.
DDx:
IHC
Features:[1]
- CD68 +ve.
- Vimentin +ve.
See also
References
- ↑ 1.0 1.1 Wang, Y.; Han, XC.; Zheng, LQ.; Miao, WL. (2014). "Xanthogranulomatous cystitis imitating bladder neoplasm: a case report and review of literature.". Int J Clin Exp Pathol 7 (11): 8255-8. PMID 25550882.
- ↑ 2.0 2.1 Ali, AM.; Nelvigi, GG.; Keshavaiah, VG.; Ratkal, CS. (Oct 2014). "Extensive xanthogranulomatous cystitis mimicking bladder cancer.". Urol Ann 6 (4): 373-5. doi:10.4103/0974-7796.141018. PMID 25371622.
- ↑ Grivas, N. (Oct 2014). "Challenges in the diagnosis of xanthogranulomatous cystitis.". Urol Ann 6 (4): 375-6. doi:10.4103/0974-7796.141019. PMID 25371623.