Difference between revisions of "Sarcomatoid urothelial carcinoma"

From Libre Pathology
Jump to navigation Jump to search
 
(6 intermediate revisions by the same user not shown)
Line 7: Line 7:
| Micro      =
| Micro      =
| Subtypes  = (subtype of [[urothelial carcinoma]])
| Subtypes  = (subtype of [[urothelial carcinoma]])
| LMDDx      = [[sarcoma]], [[carcinosarcoma]] - esp. in women, other sarcomatoid carcinomas
| LMDDx      = [[sarcoma]], [[carcinosarcoma]] - esp. in women, other sarcomatoid carcinomas, [[collision tumour]]
| Stains    =
| Stains    =
| IHC        = GATA +ve
| IHC        = GATA3 +ve
| EM        =
| EM        =
| Molecular  =
| Molecular  =
Line 33: Line 33:


==General==
==General==
*Rare.<ref name=pmid26068625/>
*Rare<ref name=pmid26068625/> approximately 0.1% of bladder carcinomas - based on the SEER database in the time span 1973-2004.<ref name=pmid20706685>{{Cite journal  | last1 = Wang | first1 = J. | last2 = Wang | first2 = FW. | last3 = Lagrange | first3 = CA. | last4 = Hemstreet Iii | first4 = GP. | last5 = Kessinger | first5 = A. | title = Clinical features of sarcomatoid carcinoma (carcinosarcoma) of the urinary bladder: analysis of 221 cases. | journal = Sarcoma | volume = 2010 | issue =  | pages =  | month =  | year = 2010 | doi = 10.1155/2010/454792 | PMID = 20706685 }}</ref>
*Aggressive >55% dead within one year of presentation.<ref name=pmid26068625/>
*Aggressive >55% dead within one year of presentation.<ref name=pmid26068625/>


Line 47: Line 47:
DDx:
DDx:
*[[Sarcoma]] - esp. those arising from the retroperitoneum.
*[[Sarcoma]] - esp. those arising from the retroperitoneum.
 
*[[Carcinosarcoma]] - esp. in women.
==IHC==
*Other [[sarcomatoid carcinoma]]s, e.g. [[sarcomatoid prostate carcinoma]].
*GATA3 +ve (16 +ve of 22 cases<ref name=pmid24824028>{{Cite journal  | last1 = Fatima | first1 = N. | last2 = Osunkoya | first2 = AO. | title = GATA3 expression in sarcomatoid urothelial carcinoma of the bladder. | journal = Hum Pathol | volume = 45 | issue = 8 | pages = 1625-9 | month = Aug | year = 2014 | doi = 10.1016/j.humpath.2014.03.015 | PMID = 24824028 }}</ref>).
*[[Collision tumour]] (rare) - components should ''not'' intermingle.  


===Images===
===Images===
Line 57: Line 57:
Image: Urothelial carcinoma with sarcomatoid differentiation -- high mag.jpg | Sarcomatoid UCC - high mag.
Image: Urothelial carcinoma with sarcomatoid differentiation -- high mag.jpg | Sarcomatoid UCC - high mag.
</gallery>
</gallery>
==IHC==
*GATA3 +ve (16 +ve of 22 cases<ref name=pmid24824028>{{Cite journal  | last1 = Fatima | first1 = N. | last2 = Osunkoya | first2 = AO. | title = GATA3 expression in sarcomatoid urothelial carcinoma of the bladder. | journal = Hum Pathol | volume = 45 | issue = 8 | pages = 1625-9 | month = Aug | year = 2014 | doi = 10.1016/j.humpath.2014.03.015 | PMID = 24824028 }}</ref>).


==See also==
==See also==

Latest revision as of 13:47, 18 April 2019

Sarcomatoid urothelial carcinoma
Diagnosis in short

Sarcomatoid urothelial carcinoma. H&E stain.
Subtypes (subtype of urothelial carcinoma)
LM DDx sarcoma, carcinosarcoma - esp. in women, other sarcomatoid carcinomas, collision tumour
IHC GATA3 +ve
Site urothelium - urinary bladder, ureter, renal pelvis

Prevalence very rare
Prognosis poor
Treatment resection if feasible

Sarcomatoid urothelial carcinoma (abbreviated sarcomatoid UC), also sarcomatoid urothelial cell carcinoma (abbreviated sarcomatoid UCC), is a rare variant of urothelial carcinoma.[1]

General

  • Rare[1] approximately 0.1% of bladder carcinomas - based on the SEER database in the time span 1973-2004.[2]
  • Aggressive >55% dead within one year of presentation.[1]

Gross

Microscopic

Features:

  1. Urothelial carcinoma (classic or recognizable variant).
  2. Sarcomatoid differentiation - typically (undifferentiated) spindle cells.

DDx:

Images

IHC

  • GATA3 +ve (16 +ve of 22 cases[5]).

See also

References

  1. 1.0 1.1 1.2 1.3 Fatima, N.; Canter, DJ.; Carthon, BC.; Kucuk, O.; Master, VA.; Nieh, PT.; Ogan, K.; Osunkoya, AO. (Jun 2015). "Sarcomatoid urothelial carcinoma of the bladder: a contemporary clinicopathologic analysis of 37 cases.". Can J Urol 22 (3): 7783-7. PMID 26068625.
  2. Wang, J.; Wang, FW.; Lagrange, CA.; Hemstreet Iii, GP.; Kessinger, A. (2010). "Clinical features of sarcomatoid carcinoma (carcinosarcoma) of the urinary bladder: analysis of 221 cases.". Sarcoma 2010. doi:10.1155/2010/454792. PMID 20706685.
  3. Nicolas, MM.; Nazarullah, A.; Guo, CC. (Apr 2014). "Sarcomatoid urothelial carcinoma with chondrosarcomatous differentiation of the ureter: a case report.". Anal Quant Cytopathol Histpathol 36 (2): 111-6. PMID 24902363.
  4. Tian, X.; Zhao, J.; Wang, Y.; Xing, N. (Sep 2014). "Sarcomatoid carcinoma of the renal pelvis: A case report.". Oncol Lett 8 (3): 1208-1210. doi:10.3892/ol.2014.2240. PMID 25120689.
  5. Fatima, N.; Osunkoya, AO. (Aug 2014). "GATA3 expression in sarcomatoid urothelial carcinoma of the bladder.". Hum Pathol 45 (8): 1625-9. doi:10.1016/j.humpath.2014.03.015. PMID 24824028.