Difference between revisions of "Sarcomatoid urothelial carcinoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Urothelial carcinoma with sarcomatoid differentiation -- intermed mag.jpg | |||
| Width = | |||
| Caption = Sarcomatoid urothelial carcinoma. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = | |||
| Subtypes = (subtype of [[urothelial carcinoma]]) | |||
| LMDDx = [[sarcoma]], [[carcinosarcoma]] - esp. in women, other sarcomatoid carcinomas, [[collision tumour]] | |||
| Stains = | |||
| IHC = GATA3 +ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[urothelium]] - [[urinary bladder]], [[ureter]], renal pelvis | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = very rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = poor | |||
| Other = | |||
| ClinDDx = | |||
| Tx = resection if feasible | |||
}} | |||
'''Sarcomatoid urothelial carcinoma''' (abbreviated '''sarcomatoid UC'''), also '''sarcomatoid urothelial cell carcinoma''' (abbreviated '''sarcomatoid UCC'''), is a rare variant of [[urothelial carcinoma]].<ref name=pmid26068625>{{Cite journal | last1 = Fatima | first1 = N. | last2 = Canter | first2 = DJ. | last3 = Carthon | first3 = BC. | last4 = Kucuk | first4 = O. | last5 = Master | first5 = VA. | last6 = Nieh | first6 = PT. | last7 = Ogan | first7 = K. | last8 = Osunkoya | first8 = AO. | title = Sarcomatoid urothelial carcinoma of the bladder: a contemporary clinicopathologic analysis of 37 cases. | journal = Can J Urol | volume = 22 | issue = 3 | pages = 7783-7 | month = Jun | year = 2015 | doi = | PMID = 26068625 }}</ref> | '''Sarcomatoid urothelial carcinoma''' (abbreviated '''sarcomatoid UC'''), also '''sarcomatoid urothelial cell carcinoma''' (abbreviated '''sarcomatoid UCC'''), is a rare variant of [[urothelial carcinoma]].<ref name=pmid26068625>{{Cite journal | last1 = Fatima | first1 = N. | last2 = Canter | first2 = DJ. | last3 = Carthon | first3 = BC. | last4 = Kucuk | first4 = O. | last5 = Master | first5 = VA. | last6 = Nieh | first6 = PT. | last7 = Ogan | first7 = K. | last8 = Osunkoya | first8 = AO. | title = Sarcomatoid urothelial carcinoma of the bladder: a contemporary clinicopathologic analysis of 37 cases. | journal = Can J Urol | volume = 22 | issue = 3 | pages = 7783-7 | month = Jun | year = 2015 | doi = | PMID = 26068625 }}</ref> | ||
==General== | ==General== | ||
*Rare.<ref name= | *Rare<ref name=pmid26068625/> approximately 0.1% of bladder carcinomas - based on the SEER database in the time span 1973-2004.<ref name=pmid20706685>{{Cite journal | last1 = Wang | first1 = J. | last2 = Wang | first2 = FW. | last3 = Lagrange | first3 = CA. | last4 = Hemstreet Iii | first4 = GP. | last5 = Kessinger | first5 = A. | title = Clinical features of sarcomatoid carcinoma (carcinosarcoma) of the urinary bladder: analysis of 221 cases. | journal = Sarcoma | volume = 2010 | issue = | pages = | month = | year = 2010 | doi = 10.1155/2010/454792 | PMID = 20706685 }}</ref> | ||
*Aggressive >55% dead within one year of presentation.<ref name=pmid26068625/> | *Aggressive >55% dead within one year of presentation.<ref name=pmid26068625/> | ||
==Gross== | |||
*Tumour of bladder, [[ureter]]<ref name=pmid24902363>{{Cite journal | last1 = Nicolas | first1 = MM. | last2 = Nazarullah | first2 = A. | last3 = Guo | first3 = CC. | title = Sarcomatoid urothelial carcinoma with chondrosarcomatous differentiation of the ureter: a case report. | journal = Anal Quant Cytopathol Histpathol | volume = 36 | issue = 2 | pages = 111-6 | month = Apr | year = 2014 | doi = | PMID = 24902363 }}</ref> or renal pelvis.<ref name=pmid25120689>{{Cite journal | last1 = Tian | first1 = X. | last2 = Zhao | first2 = J. | last3 = Wang | first3 = Y. | last4 = Xing | first4 = N. | title = Sarcomatoid carcinoma of the renal pelvis: A case report. | journal = Oncol Lett | volume = 8 | issue = 3 | pages = 1208-1210 | month = Sep | year = 2014 | doi = 10.3892/ol.2014.2240 | PMID = 25120689 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
| Line 13: | Line 47: | ||
DDx: | DDx: | ||
*[[Sarcoma]] - esp. those arising from the retroperitoneum. | *[[Sarcoma]] - esp. those arising from the retroperitoneum. | ||
*[[Carcinosarcoma]] - esp. in women. | |||
*Other [[sarcomatoid carcinoma]]s, e.g. [[sarcomatoid prostate carcinoma]]. | |||
*[[Collision tumour]] (rare) - components should ''not'' intermingle. | |||
===Images=== | ===Images=== | ||
| Line 20: | Line 57: | ||
Image: Urothelial carcinoma with sarcomatoid differentiation -- high mag.jpg | Sarcomatoid UCC - high mag. | Image: Urothelial carcinoma with sarcomatoid differentiation -- high mag.jpg | Sarcomatoid UCC - high mag. | ||
</gallery> | </gallery> | ||
==IHC== | |||
*GATA3 +ve (16 +ve of 22 cases<ref name=pmid24824028>{{Cite journal | last1 = Fatima | first1 = N. | last2 = Osunkoya | first2 = AO. | title = GATA3 expression in sarcomatoid urothelial carcinoma of the bladder. | journal = Hum Pathol | volume = 45 | issue = 8 | pages = 1625-9 | month = Aug | year = 2014 | doi = 10.1016/j.humpath.2014.03.015 | PMID = 24824028 }}</ref>). | |||
==See also== | ==See also== | ||
Latest revision as of 13:47, 18 April 2019
| Sarcomatoid urothelial carcinoma | |
|---|---|
| Diagnosis in short | |
 Sarcomatoid urothelial carcinoma. H&E stain. | |
| Subtypes | (subtype of urothelial carcinoma) |
| LM DDx | sarcoma, carcinosarcoma - esp. in women, other sarcomatoid carcinomas, collision tumour |
| IHC | GATA3 +ve |
| Site | urothelium - urinary bladder, ureter, renal pelvis |
|
| |
| Prevalence | very rare |
| Prognosis | poor |
| Treatment | resection if feasible |
Sarcomatoid urothelial carcinoma (abbreviated sarcomatoid UC), also sarcomatoid urothelial cell carcinoma (abbreviated sarcomatoid UCC), is a rare variant of urothelial carcinoma.[1]
General
- Rare[1] approximately 0.1% of bladder carcinomas - based on the SEER database in the time span 1973-2004.[2]
- Aggressive >55% dead within one year of presentation.[1]
Gross
Microscopic
Features:
- Urothelial carcinoma (classic or recognizable variant).
- Sarcomatoid differentiation - typically (undifferentiated) spindle cells.
- Approximately have 10% of heterologous elements,[1] e.g. chondrosarcomatous differentiation, osteosarcomatous differentiation.
DDx:
- Sarcoma - esp. those arising from the retroperitoneum.
- Carcinosarcoma - esp. in women.
- Other sarcomatoid carcinomas, e.g. sarcomatoid prostate carcinoma.
- Collision tumour (rare) - components should not intermingle.
Images
Sarcomatoid UCC - low mag.
Sarcomatoid UCC - intermed. mag.
Sarcomatoid UCC - high mag.
IHC
- GATA3 +ve (16 +ve of 22 cases[5]).
See also
References
- ↑ 1.0 1.1 1.2 1.3 Fatima, N.; Canter, DJ.; Carthon, BC.; Kucuk, O.; Master, VA.; Nieh, PT.; Ogan, K.; Osunkoya, AO. (Jun 2015). "Sarcomatoid urothelial carcinoma of the bladder: a contemporary clinicopathologic analysis of 37 cases.". Can J Urol 22 (3): 7783-7. PMID 26068625.
- ↑ Wang, J.; Wang, FW.; Lagrange, CA.; Hemstreet Iii, GP.; Kessinger, A. (2010). "Clinical features of sarcomatoid carcinoma (carcinosarcoma) of the urinary bladder: analysis of 221 cases.". Sarcoma 2010. doi:10.1155/2010/454792. PMID 20706685.
- ↑ Nicolas, MM.; Nazarullah, A.; Guo, CC. (Apr 2014). "Sarcomatoid urothelial carcinoma with chondrosarcomatous differentiation of the ureter: a case report.". Anal Quant Cytopathol Histpathol 36 (2): 111-6. PMID 24902363.
- ↑ Tian, X.; Zhao, J.; Wang, Y.; Xing, N. (Sep 2014). "Sarcomatoid carcinoma of the renal pelvis: A case report.". Oncol Lett 8 (3): 1208-1210. doi:10.3892/ol.2014.2240. PMID 25120689.
- ↑ Fatima, N.; Osunkoya, AO. (Aug 2014). "GATA3 expression in sarcomatoid urothelial carcinoma of the bladder.". Hum Pathol 45 (8): 1625-9. doi:10.1016/j.humpath.2014.03.015. PMID 24824028.