Difference between revisions of "Renal cell carcinoma with sarcomatoid differentiation"

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==General==
==General==
Features:<ref name=pmid11224597>{{Cite journal  | last1 = de Peralta-Venturina | first1 = M. | last2 = Moch | first2 = H. | last3 = Amin | first3 = M. | last4 = Tamboli | first4 = P. | last5 = Hailemariam | first5 = S. | last6 = Mihatsch | first6 = M. | last7 = Javidan | first7 = J. | last8 = Stricker | first8 = H. | last9 = Ro | first9 = JY. | title = Sarcomatoid differentiation in renal cell carcinoma: a study of 101 cases. | journal = Am J Surg Pathol | volume = 25 | issue = 3 | pages = 275-84 | month = Mar | year = 2001 | doi =  | PMID = 11224597 }}</ref>
Features:<ref name=pmid11224597>{{Cite journal  | last1 = de Peralta-Venturina | first1 = M. | last2 = Moch | first2 = H. | last3 = Amin | first3 = M. | last4 = Tamboli | first4 = P. | last5 = Hailemariam | first5 = S. | last6 = Mihatsch | first6 = M. | last7 = Javidan | first7 = J. | last8 = Stricker | first8 = H. | last9 = Ro | first9 = JY. | title = Sarcomatoid differentiation in renal cell carcinoma: a study of 101 cases. | journal = Am J Surg Pathol | volume = 25 | issue = 3 | pages = 275-84 | month = Mar | year = 2001 | doi =  | PMID = 11224597 }}</ref>
*Not recognized as a distinct entity in 2004 WHO classification.<ref name=pmid16442207>{{Cite journal  | last1 = Lopez-Beltran | first1 = A. | last2 = Scarpelli | first2 = M. | last3 = Montironi | first3 = R. | last4 = Kirkali | first4 = Z. | title = 2004 WHO classification of the renal tumors of the adults. | journal = Eur Urol | volume = 49 | issue = 5 | pages = 798-805 | month = May | year = 2006 | doi = 10.1016/j.eururo.2005.11.035 | PMID = 16442207 }}</ref>
*'''Not''' recognized as a distinct entity in 2004 WHO classification<ref name=pmid16442207>{{Cite journal  | last1 = Lopez-Beltran | first1 = A. | last2 = Scarpelli | first2 = M. | last3 = Montironi | first3 = R. | last4 = Kirkali | first4 = Z. | title = 2004 WHO classification of the renal tumors of the adults. | journal = Eur Urol | volume = 49 | issue = 5 | pages = 798-805 | month = May | year = 2006 | doi = 10.1016/j.eururo.2005.11.035 | PMID = 16442207 }}</ref> and after.
**It is considered an indicator of progression.
**It is considered an indicator of progression.
**Previously considered a distinct entity.<ref name=pmid22234634/><ref name=pmid16442207/><ref name=pmid10080595>{{Cite journal  | last1 = Cangiano | first1 = T. | last2 = Liao | first2 = J. | last3 = Naitoh | first3 = J. | last4 = Dorey | first4 = F. | last5 = Figlin | first5 = R. | last6 = Belldegrun | first6 = A. | title = Sarcomatoid renal cell carcinoma: biologic behavior, prognosis, and response to combined surgical resection and immunotherapy. | journal = J Clin Oncol | volume = 17 | issue = 2 | pages = 523-8 | month = Feb | year = 1999 | doi =  | PMID = 10080595 | URL = http://jco.ascopubs.org/content/17/2/523.full }}</ref>
**Previously considered a distinct entity.<ref name=pmid22234634/><ref name=pmid16442207/><ref name=pmid10080595>{{Cite journal  | last1 = Cangiano | first1 = T. | last2 = Liao | first2 = J. | last3 = Naitoh | first3 = J. | last4 = Dorey | first4 = F. | last5 = Figlin | first5 = R. | last6 = Belldegrun | first6 = A. | title = Sarcomatoid renal cell carcinoma: biologic behavior, prognosis, and response to combined surgical resection and immunotherapy. | journal = J Clin Oncol | volume = 17 | issue = 2 | pages = 523-8 | month = Feb | year = 1999 | doi =  | PMID = 10080595 | URL = http://jco.ascopubs.org/content/17/2/523.full }}</ref>
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*[[ISUP nucleolar grade]] ([[Fuhrman grade]]) 4 by definition.
*[[ISUP nucleolar grade]] ([[Fuhrman grade]]) 4 by definition.
*Most commonly seen in association with [[clear cell renal cell carcinoma]]<ref name=pmid22234634/> or [[chromophobe RCC]].<ref name=pmid15087662>{{Cite journal  | last1 = Cheville | first1 = JC. | last2 = Lohse | first2 = CM. | last3 = Zincke | first3 = H. | last4 = Weaver | first4 = AL. | last5 = Leibovich | first5 = BC. | last6 = Frank | first6 = I. | last7 = Blute | first7 = ML. | title = Sarcomatoid renal cell carcinoma: an examination of underlying histologic subtype and an analysis of associations with patient outcome. | journal = Am J Surg Pathol | volume = 28 | issue = 4 | pages = 435-41 | month = Apr | year = 2004 | doi =  | PMID = 15087662 }}</ref><ref name=pmid9331291>{{Cite journal  | last1 = Akhtar | first1 = M. | last2 = Tulbah | first2 = A. | last3 = Kardar | first3 = AH. | last4 = Ali | first4 = MA. | title = Sarcomatoid renal cell carcinoma: the chromophobe connection. | journal = Am J Surg Pathol | volume = 21 | issue = 10 | pages = 1188-95 | month = Oct | year = 1997 | doi =  | PMID = 9331291 }}</ref>
*Most commonly seen in association with [[clear cell renal cell carcinoma]]<ref name=pmid22234634/> or [[chromophobe RCC]].<ref name=pmid15087662>{{Cite journal  | last1 = Cheville | first1 = JC. | last2 = Lohse | first2 = CM. | last3 = Zincke | first3 = H. | last4 = Weaver | first4 = AL. | last5 = Leibovich | first5 = BC. | last6 = Frank | first6 = I. | last7 = Blute | first7 = ML. | title = Sarcomatoid renal cell carcinoma: an examination of underlying histologic subtype and an analysis of associations with patient outcome. | journal = Am J Surg Pathol | volume = 28 | issue = 4 | pages = 435-41 | month = Apr | year = 2004 | doi =  | PMID = 15087662 }}</ref><ref name=pmid9331291>{{Cite journal  | last1 = Akhtar | first1 = M. | last2 = Tulbah | first2 = A. | last3 = Kardar | first3 = AH. | last4 = Ali | first4 = MA. | title = Sarcomatoid renal cell carcinoma: the chromophobe connection. | journal = Am J Surg Pathol | volume = 21 | issue = 10 | pages = 1188-95 | month = Oct | year = 1997 | doi =  | PMID = 9331291 }}</ref>
==Gross==
*White solid area.
DDx:
*Degenerative changes.


==Microscopic==
==Microscopic==
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*[[Kidney tumours]].
*[[Kidney tumours]].
*[[Renal cell carcinoma with rhabdoid change]].
*[[Renal cell carcinoma with rhabdoid change]].
*[[Sarcomatoid carcinoma]].


==References==
==References==

Latest revision as of 02:50, 11 July 2015

Sarcomatoid differentiation in a chromophobe renal cell carcinoma. H&E stain.

Renal cell carcinoma with sarcomatoid differentiation is a malignant epithelial derived kidney tumour with malignant mesenchymal differentiation.

These tumours are not recognized as a distinct type of renal cell carcinoma;[1] they are classified by the non-sarcomatous component. If a renal tumour is purely sarcomatous it is renal cell carcinoma, unclassified.

Sarcomatoid renal cell carcinoma, abbreviated sarcomatoid RCC, redirects here.

General

Features:[2]

Gross

  • White solid area.

DDx:

  • Degenerative changes.

Microscopic

Features:[2]

  1. Identifiable subtype of renal cell carcinoma, e.g. clear cell renal cell carcinoma, chromophobe renal cell carcinoma, others.
  2. Sarcomatoid component:

Notes:

DDx:

Images

Case 1

Case 2

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See also

References

  1. 1.0 1.1 1.2 Shuch, B.; Bratslavsky, G.; Linehan, WM.; Srinivasan, R. (2012). "Sarcomatoid renal cell carcinoma: a comprehensive review of the biology and current treatment strategies.". Oncologist 17 (1): 46-54. doi:10.1634/theoncologist.2011-0227. PMID 22234634.
  2. 2.0 2.1 de Peralta-Venturina, M.; Moch, H.; Amin, M.; Tamboli, P.; Hailemariam, S.; Mihatsch, M.; Javidan, J.; Stricker, H. et al. (Mar 2001). "Sarcomatoid differentiation in renal cell carcinoma: a study of 101 cases.". Am J Surg Pathol 25 (3): 275-84. PMID 11224597.
  3. 3.0 3.1 Lopez-Beltran, A.; Scarpelli, M.; Montironi, R.; Kirkali, Z. (May 2006). "2004 WHO classification of the renal tumors of the adults.". Eur Urol 49 (5): 798-805. doi:10.1016/j.eururo.2005.11.035. PMID 16442207.
  4. Cangiano, T.; Liao, J.; Naitoh, J.; Dorey, F.; Figlin, R.; Belldegrun, A. (Feb 1999). "Sarcomatoid renal cell carcinoma: biologic behavior, prognosis, and response to combined surgical resection and immunotherapy.". J Clin Oncol 17 (2): 523-8. PMID 10080595.
  5. Cheville, JC.; Lohse, CM.; Zincke, H.; Weaver, AL.; Leibovich, BC.; Frank, I.; Blute, ML. (Apr 2004). "Sarcomatoid renal cell carcinoma: an examination of underlying histologic subtype and an analysis of associations with patient outcome.". Am J Surg Pathol 28 (4): 435-41. PMID 15087662.
  6. Akhtar, M.; Tulbah, A.; Kardar, AH.; Ali, MA. (Oct 1997). "Sarcomatoid renal cell carcinoma: the chromophobe connection.". Am J Surg Pathol 21 (10): 1188-95. PMID 9331291.
  7. 7.0 7.1 Dall'Oglio, MF.; Lieberknecht, M.; Gouveia, V.; Sant'Anna, AC.; Leite, KR.; Srougi, M.. "Sarcomatoid differentiation in renal cell carcinoma: prognostic implications.". Int Braz J Urol 31 (1): 10-6. PMID 15763002.
  8. Chapman-Fredricks, JR.; Herrera, L.; Bracho, J.; Gomez-Fernandez, C.; Leveillee, R.; Rey, L.; Jorda, M. (Oct 2011). "Adult renal cell carcinoma with rhabdoid morphology represents a neoplastic dedifferentiation analogous to sarcomatoid carcinoma.". Ann Diagn Pathol 15 (5): 333-7. doi:10.1016/j.anndiagpath.2011.03.002. PMID 21665507.
  9. Golshayan, AR.; George, S.; Heng, DY.; Elson, P.; Wood, LS.; Mekhail, TM.; Garcia, JA.; Aydin, H. et al. (Jan 2009). "Metastatic sarcomatoid renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy.". J Clin Oncol 27 (2): 235-41. doi:10.1200/JCO.2008.18.0000. PMID 19064974.