Difference between revisions of "Pseudohyperplastic prostatic adenocarcinoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Pseudohyperplastic carcinoma -- high mag.jpg | |||
| Width = | |||
| Caption = Pseudohyperplastic carcinoma. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = medium to large glands with an atypical morphology (papillary or pseudopapillary infoldings, luminal undulations, branching or cystic dilatation), nuclear features of conventional prostate cancer (nucleoli, nuclear enlargement) | |||
| Subtypes = subtype of [[prostate carcinoma]] | |||
| LMDDx = benign prostatic tissue, [[foamy gland carcinoma]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = [[prostate biopsy]], [[prostate chips]], [[radical prostatectomy]] | |||
| Staging = [[prostate cancer staging]] | |||
| Site = [[prostate gland]] - see ''[[prostate carcinoma]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = +/-[[PSA]] elevated | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = see ''[[prostate carcinoma]]'' | |||
}} | |||
'''Pseudohyperplastic prostatic adenocarcinoma''', also '''pseudohyperplastic adenocarcinoma''' is an uncommon type of [[prostate carcinoma]] that may mimic benign [[prostate gland|prostate]]. | '''Pseudohyperplastic prostatic adenocarcinoma''', also '''pseudohyperplastic adenocarcinoma''' is an uncommon type of [[prostate carcinoma]] that may mimic benign [[prostate gland|prostate]]. | ||
| Line 11: | Line 43: | ||
**Papillary or pseudopapillary infoldings, luminal undulations, branching or cystic dilatation. | **Papillary or pseudopapillary infoldings, luminal undulations, branching or cystic dilatation. | ||
*Nuclear features of conventional prostate cancer (nucleoli, nuclear enlargement). | *Nuclear features of conventional prostate cancer (nucleoli, nuclear enlargement). | ||
Notes: | |||
*Often associated with conventional (acinar) prostate adenocarcinoma. | |||
*Pale abundant cytoplasm - similar to normal prostate. | |||
DDx: | DDx: | ||
*[[Foamy gland carcinoma]] - often lack prominent nucleoli, smaller glands. | *[[Foamy gland carcinoma]] - often lack prominent nucleoli, smaller glands. | ||
*Benign prostatic glands. | *Benign prostatic glands - esp. at low power. | ||
===Images=== | ===Images=== | ||
<gallery> | |||
Image: Pseudohyperplastic carcinoma -- low mag.jpg | PHC - low mag. | |||
Image: Pseudohyperplastic carcinoma -- intermed mag.jpg | PHC - intermed. mag. | |||
Image: Pseudohyperplastic carcinoma -- high mag.jpg | PHC - high mag. | |||
Image: Pseudohyperplastic carcinoma - alt -- intermed mag.jpg | PHC - intermed. mag. | |||
Image: Pseudohyperplastic carcinoma - alt -- high mag.jpg | PHC - high mag. | |||
</gallery> | |||
www: | |||
*[http://www.webpathology.com/image.asp?n=29&Case=23 Pseudohyperplastic adenocarcinoma (webpathology.com)]. | *[http://www.webpathology.com/image.asp?n=29&Case=23 Pseudohyperplastic adenocarcinoma (webpathology.com)]. | ||
*[http://www.nature.com/modpathol/journal/v17/n3/fig_tab/3800050f13.html Pseudohyperplastic prostatic adenocarcinoma (nature.com)]. | *[http://www.nature.com/modpathol/journal/v17/n3/fig_tab/3800050f13.html Pseudohyperplastic prostatic adenocarcinoma (nature.com)]. | ||
==See also== | ==See also== | ||
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[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category: | [[Category:Prostate carcinoma]] | ||
Latest revision as of 03:40, 9 February 2016
| Pseudohyperplastic prostatic adenocarcinoma | |
|---|---|
| Diagnosis in short | |
 Pseudohyperplastic carcinoma. H&E stain. | |
|
| |
| LM | medium to large glands with an atypical morphology (papillary or pseudopapillary infoldings, luminal undulations, branching or cystic dilatation), nuclear features of conventional prostate cancer (nucleoli, nuclear enlargement) |
| Subtypes | subtype of prostate carcinoma |
| LM DDx | benign prostatic tissue, foamy gland carcinoma |
| Grossing notes | prostate biopsy, prostate chips, radical prostatectomy |
| Staging | prostate cancer staging |
| Site | prostate gland - see prostate carcinoma |
|
| |
| Prevalence | uncommon |
| Blood work | +/-PSA elevated |
| Treatment | see prostate carcinoma |
Pseudohyperplastic prostatic adenocarcinoma, also pseudohyperplastic adenocarcinoma is an uncommon type of prostate carcinoma that may mimic benign prostate.
General
- Uncommon <3% of cases in one series.[1]
- May mimic benign prostate.[1]
- Can be found with or without conventional prostatic adenocarcinoma (acinar type).
Microscopic
- Medium to large glands with an atypical morphology - key low power feature:
- Papillary or pseudopapillary infoldings, luminal undulations, branching or cystic dilatation.
- Nuclear features of conventional prostate cancer (nucleoli, nuclear enlargement).
Notes:
- Often associated with conventional (acinar) prostate adenocarcinoma.
- Pale abundant cytoplasm - similar to normal prostate.
DDx:
- Foamy gland carcinoma - often lack prominent nucleoli, smaller glands.
- Benign prostatic glands - esp. at low power.
Images
PHC - low mag.
PHC - intermed. mag.
PHC - high mag.
PHC - intermed. mag.
PHC - high mag.
www:
- Pseudohyperplastic adenocarcinoma (webpathology.com).
- Pseudohyperplastic prostatic adenocarcinoma (nature.com).
See also
References
- ↑ 1.0 1.1 1.2 Arista-Nasr J, Martinez-Benitez B, Valdes S, Hernández M, Bornstein-Quevedo L (2003). "Pseudohyperplastic prostatic adenocarcinoma in transurethral resections of the prostate". Pathol. Oncol. Res. 9 (4): 232–5. doi:PAOR.2003.9.4.0232. PMID 14688829.
- ↑ Zhou, Ming; Magi-Galluzzi, Cristina (2006). Genitourinary Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 77. ISBN 978-0443066771.