Difference between revisions of "Adenoid cystic/basal cell carcinoma of the prostate"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Adenoid cystic basal cell carcinoma of the prostate -- intermed mag.jpg | |||
| Width = | |||
| Caption = Adenoid cystic/basal cell carcinoma of the prostate. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = | |||
| Subtypes = | |||
| LMDDx = adenoid cystic-like [[Basal cell hyperplasia of the prostate|basal cell hyperplasia]] | |||
| Stains = | |||
| IHC = BCLA2 +ve, Ki-67 >20, HER2 +ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = [[prostate biopsy]], [[prostate chips]], [[radical prostatectomy]] | |||
| Staging = [[prostate cancer staging]] | |||
| Site = [[prostate gland]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = very rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = usually good | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Adenoid cystic/basal cell carcinoma of the prostate''', abbreviated '''ACBCC''', is a rare from of [[prostate cancer]] that resembles [[adenoid cystic carcinoma]] and [[basal cell carcinoma]]. | '''Adenoid cystic/basal cell carcinoma of the prostate''', abbreviated '''ACBCC''', is a rare from of [[prostate cancer]] that resembles [[adenoid cystic carcinoma]] and [[basal cell carcinoma]]. | ||
It is also known as '''adenoid cystic carcinoma of the prostate'''.<ref name=pmid15371944/> | |||
==General== | ==General== | ||
| Line 10: | Line 45: | ||
**Nests of cells that have round spaces filled by whispy blue mucin. | **Nests of cells that have round spaces filled by whispy blue mucin. | ||
**Dense collagenous stroma. | **Dense collagenous stroma. | ||
DDx: | |||
*Adenoid cystic-like [[Basal cell hyperplasia of the prostate|basal cell hyperplasia]]<ref name=pmid15371944>{{Cite journal | last1 = McKenney | first1 = JK. | last2 = Amin | first2 = MB. | last3 = Srigley | first3 = JR. | last4 = Jimenez | first4 = RE. | last5 = Ro | first5 = JY. | last6 = Grignon | first6 = DJ. | last7 = Young | first7 = RH. | title = Basal cell proliferations of the prostate other than usual basal cell hyperplasia: a clinicopathologic study of 23 cases, including four carcinomas, with a proposed classification. | journal = Am J Surg Pathol | volume = 28 | issue = 10 | pages = 1289-98 | month = Oct | year = 2004 | doi = | PMID = 15371944 }}</ref> - BCL2 -ve, Ki-67 low.<ref name=pmid9865831/> | |||
===Images=== | ===Images=== | ||
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*[http://www.webpathology.com/image.asp?case=23&n=16 Adenoid basal cell tumour (webpathology.com)]. | *[http://www.webpathology.com/image.asp?case=23&n=16 Adenoid basal cell tumour (webpathology.com)]. | ||
--> | --> | ||
==IHC== | ==IHC== | ||
*HER2/neu +ve (strong).<ref name=pmid17142577>{{Cite journal | last1 = Iczkowski | first1 = KA. | last2 = Montironi | first2 = R. | title = Adenoid cystic/basal cell carcinoma of the prostate strongly expresses HER-2/neu. | journal = J Clin Pathol | volume = 59 | issue = 12 | pages = 1327-30 | month = Dec | year = 2006 | doi = 10.1136/jcp.2005.035147 | PMID = 17142577 }}</ref> | *HER2/neu +ve (strong).<ref name=pmid17142577>{{Cite journal | last1 = Iczkowski | first1 = KA. | last2 = Montironi | first2 = R. | title = Adenoid cystic/basal cell carcinoma of the prostate strongly expresses HER-2/neu. | journal = J Clin Pathol | volume = 59 | issue = 12 | pages = 1327-30 | month = Dec | year = 2006 | doi = 10.1136/jcp.2005.035147 | PMID = 17142577 }}</ref> | ||
*CK34betaE12 +ve ([[Adenoid cystic carcinoma|AdCC]] component).<ref name=pmid15371944/> | |||
*BCL2 +ve.<ref name=pmid9865831>{{Cite journal | last1 = Yang | first1 = XJ. | last2 = McEntee | first2 = M. | last3 = Epstein | first3 = JI. | title = Distinction of basaloid carcinoma of the prostate from benign basal cell lesions by using immunohistochemistry for bcl-2 and Ki-67. | journal = Hum Pathol | volume = 29 | issue = 12 | pages = 1447-50 | month = Dec | year = 1998 | doi = | PMID = 9865831 }}</ref> | |||
*Ki-67 >20%.<ref name=pmid9865831/> | |||
==See also== | ==See also== | ||
*[[Prostate cancer]]. | *[[Prostate cancer]]. | ||
Latest revision as of 03:41, 9 February 2016
| Adenoid cystic/basal cell carcinoma of the prostate | |
|---|---|
| Diagnosis in short | |
 Adenoid cystic/basal cell carcinoma of the prostate. H&E stain. | |
| LM DDx | adenoid cystic-like basal cell hyperplasia |
| IHC | BCLA2 +ve, Ki-67 >20, HER2 +ve |
| Grossing notes | prostate biopsy, prostate chips, radical prostatectomy |
| Staging | prostate cancer staging |
| Site | prostate gland |
|
| |
| Prevalence | very rare |
| Prognosis | usually good |
Adenoid cystic/basal cell carcinoma of the prostate, abbreviated ACBCC, is a rare from of prostate cancer that resembles adenoid cystic carcinoma and basal cell carcinoma.
It is also known as adenoid cystic carcinoma of the prostate.[1]
General
- Rare.
- Typically indolent - may be aggressive.[2]
Microscopic
Features:
- Adenoid cystic carcinoma-like and basal cell adenoma-like:
- Nests of cells that have round spaces filled by whispy blue mucin.
- Dense collagenous stroma.
DDx:
- Adenoid cystic-like basal cell hyperplasia[1] - BCL2 -ve, Ki-67 low.[3]
Images
ADBCC - intermed. mag.
ADBCC - intermed. mag.
ADBCC - high mag.
ADBCC - very high mag.
IHC
See also
References
- ↑ 1.0 1.1 1.2 McKenney, JK.; Amin, MB.; Srigley, JR.; Jimenez, RE.; Ro, JY.; Grignon, DJ.; Young, RH. (Oct 2004). "Basal cell proliferations of the prostate other than usual basal cell hyperplasia: a clinicopathologic study of 23 cases, including four carcinomas, with a proposed classification.". Am J Surg Pathol 28 (10): 1289-98. PMID 15371944.
- ↑ Iczkowski, KA.; Ferguson, KL.; Grier, DD.; Hossain, D.; Banerjee, SS.; McNeal, JE.; Bostwick, DG. (Dec 2003). "Adenoid cystic/basal cell carcinoma of the prostate: clinicopathologic findings in 19 cases.". Am J Surg Pathol 27 (12): 1523-9. PMID 14657711.
- ↑ 3.0 3.1 3.2 Yang, XJ.; McEntee, M.; Epstein, JI. (Dec 1998). "Distinction of basaloid carcinoma of the prostate from benign basal cell lesions by using immunohistochemistry for bcl-2 and Ki-67.". Hum Pathol 29 (12): 1447-50. PMID 9865831.
- ↑ Iczkowski, KA.; Montironi, R. (Dec 2006). "Adenoid cystic/basal cell carcinoma of the prostate strongly expresses HER-2/neu.". J Clin Pathol 59 (12): 1327-30. doi:10.1136/jcp.2005.035147. PMID 17142577.