Clear cell carcinoma of the uterine cervix: Difference between revisions
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Clear cell carcinoma - gynecologic tract -- very high mag.jpg | |||
| Width = | |||
| Caption = Clear cell carcinoma of the gynecologic tract with focal clear cells. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = cells with clear cytoplasm (may be focal), hobnail pattern), moderate-to-severe [[nuclear pleomorphism]], usu. tubular and/or cystic morphology (may be (simple) papillary and/or solid) | |||
| Subtypes = | |||
| LMDDx = [[clear cell carcinoma of the vagina]], [[clear cell carcinoma of the endometrium]], [[serous carcinoma of the endometrium]], [[serous carcinoma]] of the uterine cervix, [[mesonephric adenocarcinoma]], other [[clear cell tumours]] | |||
| Stains = PAS +ve, PASD -ve | |||
| IHC = CK7 +ve, ER -ve, PR -ve, CA-125 +ve, CEA -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = [[uterine cervix]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = +/-diethylstilbestrol (DES) exposure, "young" (median age ~38 years old) | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Clear cell carcinoma of the uterine cervix''', also '''cervical clear cell carcinoma''', is a rare malignancy of the [[uterine cervix]] that classically is associated with diethylstilbestrol (DES) exposure. It typically occurs in younger women. | '''Clear cell carcinoma of the uterine cervix''', also '''cervical clear cell carcinoma''', is a rare malignancy of the [[uterine cervix]] that classically is associated with diethylstilbestrol (DES) exposure. It typically occurs in younger women. | ||
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==Microscopic== | ==Microscopic== | ||
Features:<ref name=pmid22885379/> | Features:<ref name=pmid22885379/> | ||
* | *Cells with clear cytoplasm - '''key feature'''. | ||
**May be focal/absent! | **May be focal/absent! | ||
**Cells have large free/luminal surface area (hobnailing pattern) and small non-free surface. | **Cells have large free/luminal surface area (hobnailing pattern) and small non-free surface. | ||