Clear cell carcinoma of the vagina

Clear cell carcinoma of the vagina is a very rare epithelial malignancy of the vagina.^[1]

General

Often lumped the clear cell carcinoma of the uterine cervix.^[1]

Microscopic

See clear cell carcinoma of the uterine cervix.

Images

Case

CCC - low mag.
CCC - intermed. mag.
CCC - high mag.
CCC - very high mag.
CCC - intermed. mag.
CCC - high mag.
CCC - high mag.

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CCC of the vagina (webpathology.com).

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VAGINAL VAULT, BIOPSY:
- CLEAR CELL CARCINOMA, SEE COMMENT.

COMMENT:
The tumour stains as follows:
POSITIVE: CK7, CAM5.2, PAS.
NEGATIVE: ER, PR, p53, p16, WT-1, PASD.
PROLIFERATION: ~60%.

Micro

The sections show a tumour with a papillary cystic architecture that is composed of moderately atypical monomorphic cells with moderate pale grey cytoplasm. Focal cytoplasmic clearing is present. Hobnailing is present focally. The nucleoli are not prominent.

References

↑ ^1.0 ^1.1 Ansari, DO.; Horowitz, IR.; Katzenstein, HM.; Durham, MM.; Esiashvili, N. (Jul 2012). "Successful treatment of an adolescent with locally advanced cervicovaginal clear cell adenocarcinoma using definitive chemotherapy and radiotherapy.". J Pediatr Hematol Oncol 34 (5): e174-6. doi:10.1097/MPH.0b013e318257dc91. PMID 22713709.

[pmid22713709-1] 1.0 ^1.1 Ansari, DO.; Horowitz, IR.; Katzenstein, HM.; Durham, MM.; Esiashvili, N. (Jul 2012). "Successful treatment of an adolescent with locally advanced cervicovaginal clear cell adenocarcinoma using definitive chemotherapy and radiotherapy.". J Pediatr Hematol Oncol 34 (5): e174-6. doi:10.1097/MPH.0b013e318257dc91. PMID 22713709.

[1]

Clear cell carcinoma of the vagina

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