Difference between revisions of "Succinate dehydrogenase"

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*[[Succinate dehydrogenase renal cell carcinoma]].<ref name=pmid23083876>{{Cite journal  | last1 = Ricketts | first1 = CJ. | last2 = Shuch | first2 = B. | last3 = Vocke | first3 = CD. | last4 = Metwalli | first4 = AR. | last5 = Bratslavsky | first5 = G. | last6 = Middelton | first6 = L. | last7 = Yang | first7 = Y. | last8 = Wei | first8 = MH. | last9 = Pautler | first9 = SE. | title = Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer. | journal = J Urol | volume = 188 | issue = 6 | pages = 2063-71 | month = Dec | year = 2012 | doi = 10.1016/j.juro.2012.08.030 | PMID = 23083876 }}</ref>
*[[Succinate dehydrogenase renal cell carcinoma]].<ref name=pmid23083876>{{Cite journal  | last1 = Ricketts | first1 = CJ. | last2 = Shuch | first2 = B. | last3 = Vocke | first3 = CD. | last4 = Metwalli | first4 = AR. | last5 = Bratslavsky | first5 = G. | last6 = Middelton | first6 = L. | last7 = Yang | first7 = Y. | last8 = Wei | first8 = MH. | last9 = Pautler | first9 = SE. | title = Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer. | journal = J Urol | volume = 188 | issue = 6 | pages = 2063-71 | month = Dec | year = 2012 | doi = 10.1016/j.juro.2012.08.030 | PMID = 23083876 }}</ref>
*[[Gastrointestinal stromal tumour]].
*[[Gastrointestinal stromal tumour]].
**SDHA mutations = good outcome.<ref name=pmid25188872>{{Cite journal  | last1 = Pantaleo | first1 = MA. | last2 = Lolli | first2 = C. | last3 = Nannini | first3 = M. | last4 = Astolfi | first4 = A. | last5 = Indio | first5 = V. | last6 = Saponara | first6 = M. | last7 = Urbini | first7 = M. | last8 = La Rovere | first8 = S. | last9 = Gill | first9 = A. | title = Good survival outcome of metastatic SDH-deficient gastrointestinal stromal tumors harboring SDHA mutations. | journal = Genet Med | volume =  | issue =  | pages =  | month = Sep | year = 2014 | doi = 10.1038/gim.2014.115 | PMID = 25188872 }}</ref>


==See also==
==See also==
*[[Immunohistochemistry]].
*[[Immunohistochemistry]].
*[[Neuromuscular pathology]].
*[[Neuromuscular pathology]].
*[[Carney-Stratakis syndrome]].


==References==
==References==
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[[Category:Immunohistochemistry]]
[[Category:Immunohistochemistry]]
[[Category:Molecular pathology]]

Latest revision as of 15:18, 15 March 2016

SDH immunostain in a muscle biopsy with denervation atrophy.

Succinate dehydrogenase, abbreviated SDH, is an enzyme complex in the citric acid cycle and electron transport chain. It is localized to the mitochondria.

Immunostain

  • It is used to look for mitochondrial disease.
  • Loss of staining is pathologic.

Associated pathology

Mutations in SDH genes are associated with:

See also

References

  1. ↑ 1.0 1.1 Vicha, A.; Taieb, D.; Pacak, K. (Jun 2014). "Current views on cell metabolism in SDHx-related pheochromocytoma and paraganglioma.". Endocr Relat Cancer 21 (3): R261-77. doi:10.1530/ERC-13-0398. PMID 24500761.
  2. ↑ Ricketts, CJ.; Shuch, B.; Vocke, CD.; Metwalli, AR.; Bratslavsky, G.; Middelton, L.; Yang, Y.; Wei, MH. et al. (Dec 2012). "Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer.". J Urol 188 (6): 2063-71. doi:10.1016/j.juro.2012.08.030. PMID 23083876.
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