Difference between revisions of "Nuclear atypia"
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[[Image:Colorectal adenocarcinoma - alt -- high mag.jpg|thumb|right| | [[Image:Colorectal adenocarcinoma - alt -- high mag.jpg|thumb|right|200px|Nuclear atypia and [[stromal desmoplasia]] in a [[colorectal adenocarcinoma]]. [[H&E stain]].]] | ||
'''Nuclear atypia''', also '''atypical nuclei''', is an abnormal change of the cell nucleus. | '''Nuclear atypia''', also '''atypical nuclei''', is an abnormal change of the cell nucleus. | ||
Nuclear atypia is often seen in [[malignancy]]; however, it may be seen in benign conditions - notably inflammation. | Nuclear atypia is often seen in [[malignancy]]; however, it may be seen in benign conditions - notably inflammation. Also, nuclear atypia in endocrine organs (known as ''[[endocrine atypia]]'') is considered normal. | ||
==Cancer with minimal nuclear atypia== | ==Cancer with no appreciable or minimal nuclear atypia== | ||
An incomplete list: | An incomplete list: | ||
*[[Low grade papillary urothelial carcinoma]]. | *[[Low grade papillary urothelial carcinoma]]. | ||
| Line 15: | Line 15: | ||
*[[Nuclear pleomorphism]]. | *[[Nuclear pleomorphism]]. | ||
*[[Reactive atypia]]. | *[[Reactive atypia]]. | ||
*[[Vesicular nuclei]]. | |||
*[[Endocrine atypia]]. | |||
[[Category:Basics]] | [[Category:Basics]] | ||
Latest revision as of 03:45, 7 June 2016
Nuclear atypia, also atypical nuclei, is an abnormal change of the cell nucleus.
Nuclear atypia is often seen in malignancy; however, it may be seen in benign conditions - notably inflammation. Also, nuclear atypia in endocrine organs (known as endocrine atypia) is considered normal.
Cancer with no appreciable or minimal nuclear atypia
An incomplete list:
- Low grade papillary urothelial carcinoma.
- Some adenocarcinomas of the upper gastrointestinal tract, e.g. gallbladder adenocarcinoma, stomach adenocarcinoma, ductal adenocarcinoma of the pancreas.
- Invasive lobular carcinoma.
- Verrucous squamous cell carcinoma.
- Some malignant melanomas.