Phyllodes tumour: Difference between revisions
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'''Phyllodes tumour''' is a tumour of the intralobular breast stroma. It may be benign or [[malignant]]. | '''Phyllodes tumour''' is a tumour of the intralobular breast stroma. It may be benign or [[malignant]]. | ||
It was previously called '''cystosarcoma phyllodes'''. | It was previously called '''cystosarcoma phyllodes'''. It is a type of [[fibroepithelial tumours of the breast|fibroepithelial tumour]]. | ||
==General== | ==General== | ||
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Image:Phyllodes_tumour_-_very_low_mag.jpg | Phyllodes tumour - very low mag. (WC/Nephron) | Image:Phyllodes_tumour_-_very_low_mag.jpg | Phyllodes tumour - very low mag. (WC/Nephron) | ||
Image:Phyllodes_tumour_-_low_mag.jpg | Phyllodes tumour - low mag. (WC/Nephron) | Image:Phyllodes_tumour_-_low_mag.jpg | Phyllodes tumour - low mag. (WC/Nephron) | ||
Image:Malignant phyllodes tumour.jpg |Malignant phyllodes tumour - low mag (WC) | |||
Image:Malignant phyllodes tumour high magnification.jpg |Malignant phyllodes tumour - high mag (WC) | |||
</gallery> | </gallery> | ||
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* † Stromal overgrowth = epithelial elements absent in one low power field (LPF), defined as x40;<ref name=pmid17932112>{{cite journal |author=Taira N, Takabatake D, Aogi K, ''et al'' |title=Phyllodes tumor of the breast: stromal overgrowth and histological classification are useful prognosis-predictive factors for local recurrence in patients with a positive surgical margin |journal=Jpn. J. Clin. Oncol. |volume=37 |issue=10 |pages=730-6 |year=2007 |month=October |pmid=17932112 |doi=10.1093/jjco/hym099 |url=http://jjco.oxfordjournals.org/cgi/reprint/37/10/730}}</ref> ''LPF'' is not adequately defined - see [[LPFitis]]. | * † Stromal overgrowth = epithelial elements absent in one low power field (LPF), defined as x40;<ref name=pmid17932112>{{cite journal |author=Taira N, Takabatake D, Aogi K, ''et al'' |title=Phyllodes tumor of the breast: stromal overgrowth and histological classification are useful prognosis-predictive factors for local recurrence in patients with a positive surgical margin |journal=Jpn. J. Clin. Oncol. |volume=37 |issue=10 |pages=730-6 |year=2007 |month=October |pmid=17932112 |doi=10.1093/jjco/hym099 |url=http://jjco.oxfordjournals.org/cgi/reprint/37/10/730}}</ref> ''LPF'' is not adequately defined - see [[LPFitis]]. | ||
* ‡ ''HPF'' is not adequately defined - see [[HPFitis]]. | * ‡ ''HPF'' is not adequately defined - see [[HPFitis]]. | ||
==IHC== | |||
Epithelial component: | |||
*CK7 +ve. | |||
*ER. | |||
*PR. | |||
Stromal cells:<ref name=pmid14608534>{{cite journal |authors=Dunne B, Lee AH, Pinder SE, Bell JA, Ellis IO |title=An immunohistochemical study of metaplastic spindle cell carcinoma, phyllodes tumor and fibromatosis of the breast |journal=Hum Pathol |volume=34 |issue=10 |pages=1009–15 |date=October 2003 |pmid=14608534 |doi=10.1053/s0046-8177(03)00414-3 |url=}}</ref> | |||
*CD34 +ve. | |||
*BCL2 +ve. | |||
*CK -ve. | |||
*GATA-3 -ve.<ref name=pmid23375642>{{cite journal |authors=Cimino-Mathews A, Subhawong AP, Illei PB, Sharma R, Halushka MK, Vang R, Fetting JH, Park BH, Argani P |title=GATA3 expression in breast carcinoma: utility in triple-negative, sarcomatoid, and metastatic carcinomas |journal=Hum Pathol |volume=44 |issue=7 |pages=1341–9 |date=July 2013 |pmid=23375642 |pmc=3991123 |doi=10.1016/j.humpath.2012.11.003 |url=}}</ref> | |||
==Sign out== | |||
===Benign=== | |||
<pre> | |||
Right Breast Mass, Excision: | |||
- Benign phyllodes tumour. | |||
- NEGATIVE for malignancy. | |||
</pre> | |||
====Micro==== | |||
The sections show a well-circumscribed mass with a leaf-like architecture. There is no stromal overgrowth or atypia. Proliferative activity is not readily apparent. | |||
==See also== | ==See also== | ||