Difference between revisions of "Heterotopic ossification"

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#redirect [[Ditzels#Heterotopic_ossification]]
'''Heterotopic ossification''' is an uncommon [[pathology]] specimen that may be considered a [[ditzel]].
 
==General==
*Definition of ''heterotopic ossification'': bone formation in soft tissue.<ref name=pmid21611960>{{Cite journal  | last1 = Leblanc | first1 = E. | last2 = Trensz | first2 = F. | last3 = Haroun | first3 = S. | last4 = Drouin | first4 = G. | last5 = Bergeron | first5 = E. | last6 = Penton | first6 = CM. | last7 = Montanaro | first7 = F. | last8 = Roux | first8 = S. | last9 = Faucheux | first9 = N. | title = BMP-9-induced muscle heterotopic ossification requires changes to the skeletal muscle microenvironment. | journal = J Bone Miner Res | volume = 26 | issue = 6 | pages = 1166-77 | month = Jun | year = 2011 | doi = 10.1002/jbmr.311 | PMID = 21611960 }}
</ref>
*Injury at site.
*May be seen in the context of tetraplegia.
 
Clinical:<ref name=pmid21611960/>
*+/-Joint stiffness.
*+/-Swelling.
*+/-Pain.
 
==Gross==
*Firm nodule.
 
==Microscopic==
Features:
*[[Lamellar bone]] - has layering/lines (best seen with polarized light).
*+/-Skeletal muscle (within the marrow space).
 
DDx:
*[[Myositis ossificans]] - inflammation, cellular.
*[[Osteosarcoma]], extraskeletal.
*[[Osteochrondroma]] - at joint, has cartilage.{{fact}}
*[[Pilomatricoma]] - may be extensively ossified.<ref name=pmid20439187>{{Cite journal  | last1 = Ioannidis | first1 = O. | last2 = Stavrakis | first2 = T. | last3 = Cheva | first3 = A. | last4 = Papadimitriou | first4 = N. | last5 = Kotronis | first5 = A. | last6 = Kakoutis | first6 = E. | last7 = Makrantonakis | first7 = N. | title = Pilomatricoma of the arm with extensive ossification. | journal = Adv Med Sci | volume = 55 | issue = 2 | pages = 340-2 | month =  | year = 2010 | doi = 10.2478/v10039-010-0010-y | PMID = 20439187 }}</ref>
 
==Sign out==
<pre>
Lesion, Distal Phalanx of Right Little Finger, Excision:
- Dermal ossification without cartilage in benign skin with a thick keratin layer.
- NEGATIVE for evidence of malignancy.
</pre>
 
===Block letters===
<pre>
LESION ("HETEROTOPIC OSSIFICATION"), RIGHT FEMUR, EXCISION:
- BONE -- CONSISTENT WITH MUSCLE HETEROTOPIC OSSIFICATION.
- NEGATIVE FOR MALIGNANCY.
</pre>
 
===Micro===
The sections show laminar bone with a marrow space containing adipose tissue and benign skeletal muscle. The osteocytes show no nuclear atypia. No mitotic activity is appreciated.
 
==See also==
*[[Ditzels]].
*[[Bone]].
*[[Cutaneous calcification]].
*[[Osseous metaplasia]].
 
==References==
{{Reflist|1}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Ditzels]]

Latest revision as of 02:53, 6 January 2017

Heterotopic ossification is an uncommon pathology specimen that may be considered a ditzel.

General

  • Definition of heterotopic ossification: bone formation in soft tissue.[1]
  • Injury at site.
  • May be seen in the context of tetraplegia.

Clinical:[1]

  • +/-Joint stiffness.
  • +/-Swelling.
  • +/-Pain.

Gross

  • Firm nodule.

Microscopic

Features:

  • Lamellar bone - has layering/lines (best seen with polarized light).
  • +/-Skeletal muscle (within the marrow space).

DDx:

Sign out

Lesion, Distal Phalanx of Right Little Finger, Excision:
- Dermal ossification without cartilage in benign skin with a thick keratin layer.
- NEGATIVE for evidence of malignancy.

Block letters

LESION ("HETEROTOPIC OSSIFICATION"), RIGHT FEMUR, EXCISION:
- BONE -- CONSISTENT WITH MUSCLE HETEROTOPIC OSSIFICATION.
- NEGATIVE FOR MALIGNANCY.

Micro

The sections show laminar bone with a marrow space containing adipose tissue and benign skeletal muscle. The osteocytes show no nuclear atypia. No mitotic activity is appreciated.

See also

References

  1. 1.0 1.1 Leblanc, E.; Trensz, F.; Haroun, S.; Drouin, G.; Bergeron, E.; Penton, CM.; Montanaro, F.; Roux, S. et al. (Jun 2011). "BMP-9-induced muscle heterotopic ossification requires changes to the skeletal muscle microenvironment.". J Bone Miner Res 26 (6): 1166-77. doi:10.1002/jbmr.311. PMID 21611960.
  2. Ioannidis, O.; Stavrakis, T.; Cheva, A.; Papadimitriou, N.; Kotronis, A.; Kakoutis, E.; Makrantonakis, N. (2010). "Pilomatricoma of the arm with extensive ossification.". Adv Med Sci 55 (2): 340-2. doi:10.2478/v10039-010-0010-y. PMID 20439187.