Difference between revisions of "Laryngeal carcinoma"

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Risk factors:<ref name=Ref_PCPBoD8_396>{{Ref PCPBoD8|396}}</ref>
Risk factors:<ref name=Ref_PCPBoD8_396>{{Ref PCPBoD8|396}}</ref>
# Smoking.
# [[Smoking]].
# Alcohol.
# [[Alcohol]].


Note:
*Asbestos exposure is also reported to be associated.<Ref name=pmid24351898>{{Cite journal  | last1 = Offermans | first1 = NS. | last2 = Vermeulen | first2 = R. | last3 = Burdorf | first3 = A. | last4 = Goldbohm | first4 = RA. | last5 = Kauppinen | first5 = T. | last6 = Kromhout | first6 = H. | last7 = van den Brandt | first7 = PA. | title = Occupational asbestos exposure and risk of pleural mesothelioma, lung cancer, and laryngeal cancer in the prospective Netherlands cohort study. | journal = J Occup Environ Med | volume = 56 | issue = 1 | pages = 6-19 | month = Jan | year = 2014 | doi = 10.1097/JOM.0000000000000060 | PMID = 24351898 }}</ref>
====Carinoma - subclassification by site====
====Carinoma - subclassification by site====
It is generally divided the following way:<ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Larynx_11protocol.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Larynx_11protocol.pdf]. Accessed on: 2 May 2012.</ref>
It is generally divided the following way:<ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Larynx_11protocol.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Larynx_11protocol.pdf]. Accessed on: 2 May 2012.</ref>
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Features:<ref name=Ref_WMSP24>{{Ref WMSP|24}}</ref>
Features:<ref name=Ref_WMSP24>{{Ref WMSP|24}}</ref><ref>URL: [http://www.health.am/cr/more/statistics-and-prognosis-for-cancer-of-the-larynx/ http://www.health.am/cr/more/statistics-and-prognosis-for-cancer-of-the-larynx/]. Accessed on: 2 May 2012.</ref>
*Prevalence - supraglottic & glottic > subglottic.
*Prevalence - glottis > supraglottis > subglottis.
*Glottic tend to present earlier - as they affect phonation.
*Glottic carcinoma tends to present earlier (as it affects phonation) and, therefore, has a better prognosis.


===Microscopic===
===Microscopic===
:See [[squamous cell carcinoma]].
:See [[squamous cell carcinoma]].
===Sign out===
<pre>
LEFT FALSE VOCAL CORD, BIOPSY:
- INVASIVE SQUAMOUS CELL CARCINOMA, MODERATELY DIFFERENTIATED, NONKERATINIZING,
  WITH LYMPHOVASCULAR INVASION.
COMMENT:
The presence of invasive squamous cell carcinoma is confirmed by a second pathologist.
</pre>


=See also=
=See also=
*[[Head and neck pathology]].
*[[Head and neck pathology]].
*[[Squamous cell carcinoma]].
*[[Squamous cell carcinoma]].
*[[Laryngectomy]].


=References=
=References=

Latest revision as of 14:45, 13 November 2020

Laryngeal carcinoma is a subset of head and neck pathology.

Normal histology

The normal histology is dependent on the site.[1]

Pathology

Laryngeal squamous cell carcinoma

General

  • 95% of laryngeal carcinomas.[2]

Risk factors:[2]

  1. Smoking.
  2. Alcohol.

Note:

  • Asbestos exposure is also reported to be associated.[3]

Carinoma - subclassification by site

It is generally divided the following way:[4]

 
 
 
 
 
 
 
 
Laryngeal cancer
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Supraglottis
 
 
Glottis
 
 
Subglottis

Features:[5][6]

  • Prevalence - glottis > supraglottis > subglottis.
  • Glottic carcinoma tends to present earlier (as it affects phonation) and, therefore, has a better prognosis.

Microscopic

See squamous cell carcinoma.

Sign out

LEFT FALSE VOCAL CORD, BIOPSY:
- INVASIVE SQUAMOUS CELL CARCINOMA, MODERATELY DIFFERENTIATED, NONKERATINIZING,
  WITH LYMPHOVASCULAR INVASION.

COMMENT:
The presence of invasive squamous cell carcinoma is confirmed by a second pathologist.

See also

References

  1. ↑ Koren, R.; Kristt, D.; Shvero, J.; Yaniv, E.; Dekel, Y.; Gal, R. (2002). "The spectrum of laryngeal neoplasia: the pathologist's view.". Pathol Res Pract 198 (11): 709-15. PMID 12530572.
  2. ↑ 2.0 2.1 Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 396. ISBN 978-1416054542.
  3. ↑ Offermans, NS.; Vermeulen, R.; Burdorf, A.; Goldbohm, RA.; Kauppinen, T.; Kromhout, H.; van den Brandt, PA. (Jan 2014). "Occupational asbestos exposure and risk of pleural mesothelioma, lung cancer, and laryngeal cancer in the prospective Netherlands cohort study.". J Occup Environ Med 56 (1): 6-19. doi:10.1097/JOM.0000000000000060. PMID 24351898.
  4. ↑ URL: http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Larynx_11protocol.pdf. Accessed on: 2 May 2012.
  5. ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 24. ISBN 978-0781765275.
  6. ↑ URL: http://www.health.am/cr/more/statistics-and-prognosis-for-cancer-of-the-larynx/. Accessed on: 2 May 2012.
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