Difference between revisions of "Tumour suppressor gene"

Latest revision as of 06:13, 16 December 2014

A tumour suppressor gene is a gene that acts to protect the organism which it is within from developing cancer.

Gene	Syndrome or disease
TP53 (p53)^[1]	Li-Fraumeni syndrome
BRCA1^[2]	Familial breast-ovarian cancer 1
RB1^[3]	Retinoblastoma
VHL^[4]	Von Hippel-Lindau disease
NF1^[5]	Neurofibromatosis type 1
TSC1^[6] (hamartin)	Tuberous sclerosis
TSC2^[6] (tuberin)	Tuberous sclerosis

@@ Line 1: / Line 1: @@
 A '''tumour suppressor gene''' is a gene that acts to protect the organism which it is within from developing [[cancer]].
-Examples of tumour suppressors:
+==Examples==
-*TP53 (p53).<ref>{{OMIM|191170}}</ref>
+{| class="wikitable sortable"
-*BRCA1.<ref>{{OMIM|113705}}</ref>
+! Gene
+! Syndrome or disease
+|-
+| TP53 (p53)<ref>{{OMIM|191170}}</ref>
+| [[Li-Fraumeni syndrome]]
+|-
+| [[BRCA1]]<ref>{{OMIM|113705}}</ref>
+| Familial breast-ovarian cancer 1
+|-
+| RB1<ref>{{OMIM|614041}}</ref>
+| [[Retinoblastoma]]
+|-
+| VHL<ref>{{OMIM|608537}}</ref>
+| [[Von Hippel-Lindau disease]]
+|-
+| NF1<ref>{{OMIM|613113}}</ref>
+| [[Neurofibromatosis type 1]]
+|-
+| TSC1<ref name=pmid11266527>{{Cite journal  | last1 = Johnson | first1 = MW. | last2 = Kerfoot | first2 = C. | last3 = Bushnell | first3 = T. | last4 = Li | first4 = M. | last5 = Vinters | first5 = HV. | title = Hamartin and tuberin expression in human tissues. | journal = Mod Pathol | volume = 14 | issue = 3 | pages = 202-10 | month = Mar | year = 2001 | doi = 10.1038/modpathol.3880286 | PMID = 11266527 }}</ref> (hamartin)
+| [[Tuberous sclerosis]]
+|-
+| TSC2<ref name=pmid11266527/> (tuberin)
+| Tuberous sclerosis
+|}
 ==See also==
 *[[Cancer]].
 *[[Molecular pathology]].
+*[[Oncogene]].
 ==References==
-{{Reflist|1}}
+{{Reflist|2}}
 [[Category:Molecular pathology]]