Difference between revisions of "Endometrial hyperplasia"

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===Microscopic===
===Microscopic===
Features:
Features:
*Increase in size & number of glands + irreg. shape.
*Increase in size & number of glands + irregular shape.
**Need cribriform architecture.
**Two "touching" glands are likely one gland in section.
*Cell stratification.
*Cell stratification.
*Nuclear enlargement.
*Nuclear enlargement.
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Notes:  
Notes:  
*Normal ''gland-to-stroma ratio'' is 1:3.
*Normal "gland-to-stroma ratio" is 1:3.
*Two "touching" glands may be one gland in section.
 


Image:
Image:
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[[Endometrial carcinoma]] vs. complex endometrial hyperplasia:
[[Endometrial carcinoma]] vs. complex endometrial hyperplasia:
*Complex endometrial hyperplasia: non-confluent (glands distinct from one another).
*Complex endometrial hyperplasia: non-confluent (glands distinct from one another).
*Diagnosis of complex EH is based on histology (cytologic features).
*Endometrial carcinoma - one of the following:<ref name=Ref_GP239>{{Ref GP|239}}</ref>
*#Cribriform architecture.
*#Desmoplastic stromal response.
*#Extensive papillary pattern.
*#Stroma replaced by squamous epithelium.


==Complex endometrial hyperplasia with atypia==
==Complex endometrial hyperplasia with atypia==
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