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Difference between revisions of "Endometrial hyperplasia"
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Endometrial hyperplasia (view source)
Revision as of 01:27, 7 November 2011
, 01:27, 7 November 2011→Simple endometrial hyperplasia with atypia: more
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==Simple endometrial hyperplasia with atypia== | ==Simple endometrial hyperplasia with atypia== | ||
===General=== | |||
*Uncommon. | |||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features:<ref name=Ref_GP236>{{Ref GP|236}}</ref> | ||
*Irregular | *Irregular dilated glands (with large lumens) - '''important feature'''. | ||
**Glands described as "animal shapes". | |||
*Variation of gland size. | *Variation of gland size. | ||
*No nuclear atypia. | |||
**Uniform columnar nuclei. | |||
*Normal gland density (gland area in plane of section/total area ~= 1/3). | |||
*Nuclear atypia:<ref>{{Cite journal | last1 = Silverberg | first1 = SG. | title = Problems in the differential diagnosis of endometrial hyperplasia and carcinoma. | journal = Mod Pathol | volume = 13 | issue = 3 | pages = 309-27 | month = Mar | year = 2000 | doi = 10.1038/modpathol.3880053 | PMID = 10757341 }}</ref> | *Nuclear atypia:<ref>{{Cite journal | last1 = Silverberg | first1 = SG. | title = Problems in the differential diagnosis of endometrial hyperplasia and carcinoma. | journal = Mod Pathol | volume = 13 | issue = 3 | pages = 309-27 | month = Mar | year = 2000 | doi = 10.1038/modpathol.3880053 | PMID = 10757341 }}</ref> | ||
**Loss of basal nuclear stratification | **Loss of basal nuclear stratification. | ||
**Nuclear size variation. | **Nuclear size variation. | ||
**Nuclear rounding. | **Nuclear rounding. | ||
***Nuclei lacking atypical = uniform columnar nuclei. | ***Nuclei lacking atypical = uniform columnar nuclei. | ||
**Nucleoli. | **Nucleoli. | ||
**Hyperchromasia or vesicular nuclei. | |||
Notes: | |||
*There are no clear criteria for atypia. Different sources list different features. | |||
*VL criteria for atypia: | |||
*#Increased NC ratio | |||
*#*Atypical: ~ 1:2 | |||
*#*Not atypical: ~1:3. | |||
*#Oval nuclei with small major axis to minor axis ratio. | |||
*#*Atypical: major axis:minor axis = <=2:1. | |||
*#*Not atypical: major axis:minor axis = >=3:1 | |||
*#**NB: round nuclei: major axis:minor axis = 1:1. | |||
*#Nucleoli. | |||
==Complex endometrial hyperplasia== | ==Complex endometrial hyperplasia== | ||