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Difference between revisions of "Lymphovascular invasion"
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'''Lymphovascular invasion''', also '''lymphovascular space invasion''', is (non-hematologic) malignant cells within [[blood vessels]] and/or lymphatics. It is abbreviated '''LVI'''. | '''Lymphovascular invasion''', also '''lymphovascular space invasion''', is (non-hematologic) malignant cells within [[blood vessels]] and/or lymphatics. It is abbreviated '''LVI'''. | ||
The term ''lymphovascular invasion'' | In some contexts, ''[[vascular invasion]]'' (also ''angioinvasion'') must be separated from ''lymphovascular invasion''.<ref>{{cite journal |authors=Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG |title=Overview of the 2022 WHO Classification of Adrenal Cortical Tumors |journal=Endocr Pathol |volume=33 |issue=1 |pages=155–196 |date=March 2022 |pmid=35288842 |pmc=8920443 |doi=10.1007/s12022-022-09710-8 |url=}}</ref> | ||
The term ''lymphovascular invasion'' was traditionally preferred to ''[[vascular invasion]]'', as it is difficult to differentiate morphologically small lymphatics and small vascular spaces, without [[immunohistochemistry]]. | |||
==General== | ==General== | ||
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Image: CRC with LVI - HE - alt -- high mag.jpg | CRC with LVI - high mag. (WC/Nephron) | Image: CRC with LVI - HE - alt -- high mag.jpg | CRC with LVI - high mag. (WC/Nephron) | ||
Image: CRC with LVI - HE -- very high mag.jpg | CRC with LVI - very high mag. (WC/Nephron) | Image: CRC with LVI - HE -- very high mag.jpg | CRC with LVI - very high mag. (WC/Nephron) | ||
</gallery> | |||
Image: CRC with LVI - elastin -- very low mag.jpg | CRC with LVI - elastin - very low mag. (WC/Nephron) | ==Stains== | ||
*[[Movat stain]] - especially useful in [[colorectal carcinoma]] so one can readily identify [[blood vessel]]s.<ref name=pmid19861561>{{Cite journal | last1 = Howlett | first1 = CJ. | last2 = Tweedie | first2 = EJ. | last3 = Driman | first3 = DK. | title = Use of an elastic stain to show venous invasion in colorectal carcinoma: a simple technique for detection of an important prognostic factor. | journal = J Clin Pathol | volume = 62 | issue = 11 | pages = 1021-5 | month = Nov | year = 2009 | doi = 10.1136/jcp.2009.065615 | PMID = 19861561 }}</ref> | |||
*Elastin stain. | |||
===Images=== | |||
<gallery> | |||
Image: CRC with LVI - elastin -- very low mag.jpg | [[colorectal carcinoma|CRC]] with LVI - elastin - very low mag. (WC/Nephron) | |||
Image: CRC with LVI - elastin -- low mag.jpg | CRC with LVI - elastin - low mag. (WC/Nephron) | Image: CRC with LVI - elastin -- low mag.jpg | CRC with LVI - elastin - low mag. (WC/Nephron) | ||
Image: CRC with LVI - elastin -- intermed mag.jpg | CRC with LVI - elastin - intermed. mag. (WC/Nephron) | Image: CRC with LVI - elastin -- intermed mag.jpg | CRC with LVI - elastin - intermed. mag. (WC/Nephron) | ||
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Image: CRC with LVI - elastin -- very high mag.jpg | CRC with LVI - elastin - very high mag. (WC/Nephron) | Image: CRC with LVI - elastin -- very high mag.jpg | CRC with LVI - elastin - very high mag. (WC/Nephron) | ||
</gallery> | </gallery> | ||
==IHC== | ==IHC== | ||
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*[[Perineural invasion]]. | *[[Perineural invasion]]. | ||
*[[Angioinvasion]]. | *[[Angioinvasion]]. | ||
*[[MELF]]. | |||
==References== | ==References== | ||