Difference between revisions of "Uterine tubes"

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Uterine tubes (view source)

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[[Image:Normal Fallopian Tube, Human (2760475010).jpg|thumb|Cross section of a Fallopian tube with decidualization. [[H&E stain]]. (WC/euthman)]]
'''Uterine tubes''', also known as the '''Fallopian tubes''', serve as a connection between the [[ovary|ovaries]] and the [[uterus]].  It is where fertilization usually takes place.
'''Uterine tubes''', also known as the '''Fallopian tubes''', serve as a connection between the [[ovary|ovaries]] and the [[uterus]].  It is where fertilization usually takes place.


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#*Nucleus more luminal.
#*Nucleus more luminal.
#**Nuclei stick-out like a golf tee.
#**Nuclei stick-out like a golf tee.
#Secretory cells.
#Secretory cells. (???)
#*Basal cells, fried egg-like.


Images:
See also:
*[[Walthard cell rest]].
 
===Images===
www:
*[http://faculty.une.edu/com/abell/histo/ampovidw.jpg Fallopian tube (une.edu)].<ref>URL: [http://faculty.une.edu/com/abell/histo/histolab3f.htm http://faculty.une.edu/com/abell/histo/histolab3f.htm]. Accessed on: 18 October 2011.</ref>
*[http://faculty.une.edu/com/abell/histo/ampovidw.jpg Fallopian tube (une.edu)].<ref>URL: [http://faculty.une.edu/com/abell/histo/histolab3f.htm http://faculty.une.edu/com/abell/histo/histolab3f.htm]. Accessed on: 18 October 2011.</ref>
*[http://medpics.ucsd.edu/index.cfm?curpage=image&course=hist&mode=browse&lesson=37&img=669 Fallopian tube (medpics.ucsd.edu)].
*[http://medpics.ucsd.edu/index.cfm?curpage=image&course=hist&mode=browse&lesson=37&img=669 Fallopian tube (medpics.ucsd.edu)].
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{{Main|Ditzels}}
{{Main|Ditzels}}
==Paratubal cyst==
==Paratubal cyst==
*Also known as ''Hydatid cyst of Morgagni'' and ''Hydatid of Morgagni''.
===General===
===General===
*Very common.
*Very common.
*May lead to ovarian torsion if very large.<ref name=pmid22840942>{{Cite journal  | last1 = Thakore | first1 = SS. | last2 = Chun | first2 = MJ. | last3 = Fitzpatrick | first3 = K. | title = Recurrent ovarian torsion due to paratubal cysts in an adolescent female. | journal = J Pediatr Adolesc Gynecol | volume = 25 | issue = 4 | pages = e85-7 | month = Aug | year = 2012 | doi = 10.1016/j.jpag.2011.10.012 | PMID = 22840942 }}
*May lead to ovarian torsion if very large.<ref name=pmid22840942>{{Cite journal  | last1 = Thakore | first1 = SS. | last2 = Chun | first2 = MJ. | last3 = Fitzpatrick | first3 = K. | title = Recurrent ovarian torsion due to paratubal cysts in an adolescent female. | journal = J Pediatr Adolesc Gynecol | volume = 25 | issue = 4 | pages = e85-7 | month = Aug | year = 2012 | doi = 10.1016/j.jpag.2011.10.012 | PMID = 22840942 }}
</ref>
</ref>
*Associated with [[obesity]].<ref>{{Cite journal  | last1 = Muolokwu | first1 = E. | last2 = Sanchez | first2 = J. | last3 = Bercaw | first3 = JL. | last4 = Sangi-Haghpeykar | first4 = H. | last5 = Banszek | first5 = T. | last6 = Brandt | first6 = ML. | last7 = Dietrich | first7 = JE. | title = Paratubal cysts, obesity, and hyperandrogenism. | journal = J Pediatr Surg | volume = 46 | issue = 11 | pages = 2164-7 | month = Nov | year = 2011 | doi = 10.1016/j.jpedsurg.2011.07.011 | PMID = 22075351 }}</ref>


===Gross===
===Gross===
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===Sign out===
===Sign out===
====Left then right====
====Left then right====
<pre>
A. Fallopian Tube, Left, Tubal Ligation:
- Fallopian tube within normal limits, consistent with complete cross sections.
B. Fallopian Tube, Right, Tubal Ligation:
- Fallopian tube within normal limits, consistent with complete cross sections.
</pre>
<pre>
<pre>
A. FALLOPIAN TUBE, LEFT, TUBAL LIGATION:
A. FALLOPIAN TUBE, LEFT, TUBAL LIGATION:
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====Right then left====
====Right then left====
<pre>
A. Fallopian Tube, Right, Tubal Ligation:
- Fallopian tube within normal limits, consistent with complete cross sections.
B. Fallopian Tube, Left, Tubal Ligation:
- Fallopian tube within normal limits, consistent with complete cross sections.
</pre>
<pre>
<pre>
A. FALLOPIAN TUBE, RIGHT, TUBAL LIGATION:
A. FALLOPIAN TUBE, RIGHT, TUBAL LIGATION:
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B. FALLOPIAN TUBE, LEFT, TUBAL LIGATION:
B. FALLOPIAN TUBE, LEFT, TUBAL LIGATION:
- FALLOPIAN TUBE WITHIN NORMAL LIMITS.
- FALLOPIAN TUBE WITHIN NORMAL LIMITS.
</pre>
====Both in one container====
<pre>
Submitted as "Fallopian Tubes Right and Left", Tubal Ligation:
    - Pieces of Fallopian tube within normal limits, consistent with
      complete cross sections.
</pre>
<pre>
Submitted as "Fallopian Tubes Right and Left", Partial Excision:
    - Pieces of Fallopian tube within normal limits, consistent with
      complete cross sections and fibril ends.
</pre>
=====Incomplete cross sections at microscopy=====
<pre>
Submitted as "Right and Left Fallopian Tubes", Tubal Ligation:
    - Fallopian tubes within normal limits, incomplete cross sections
      seen at microscopy; clinical correlation is suggested.
</pre>
=====Mild inflammation=====
<pre>
Submitted as "Fallopian Tubes Right and Left", Tubal Ligation:
    - Pieces of Fallopian tube with mild inflammation otherwise within
      normal limits, consistent with complete cross sections.
</pre>
</pre>


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- FALLOPIAN TUBE WITH PARATUBAL CYSTS AND FOCAL FIBROSIS.
- FALLOPIAN TUBE WITH PARATUBAL CYSTS AND FOCAL FIBROSIS.
- OVARY WITHIN NORMAL LIMITS.
- OVARY WITHIN NORMAL LIMITS.
</pre>
====Tubes with fimbria====
<pre>
Submitted as "Right and Left Fallopian Tube Segments", Excision:
    - Fallopian tubes with fimbria within normal limits; complete cross sections seen.
</pre>
</pre>


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*+/-Clusters of neutrophils = abscess; known as ''suppurative salpingitis''.
*+/-Clusters of neutrophils = abscess; known as ''suppurative salpingitis''.


Images:
====Images====
*[http://commons.wikimedia.org/wiki/File:Salpingitis_-_low_mag.jpg Salpingitis - low mag. (WC)].
<gallery>
*[http://commons.wikimedia.org/wiki/File:Salpingitis_-_high_mag.jpg Salpingitis - high mag. (WC)].
File:Salpingitis_-_low_mag.jpg | Salpingitis - low mag. (WC)
*[http://commons.wikimedia.org/wiki/File:Granulomatous_salpingitis_-_intermed_mag.jpg Granulomatous salpingitis - intermed mag. (WC)].
File:Salpingitis_-_high_mag.jpg | Salpingitis - high mag. (WC)
*[http://commons.wikimedia.org/wiki/File:Granulomatous_salpingitis_-_high_mag.jpg Granulomatous salpingitis - high mag. (WC)].
File:Granulomatous_salpingitis_-_intermed_mag.jpg | Granulomatous salpingitis - intermed mag. (WC)
 
File:Granulomatous_salpingitis_-_high_mag.jpg | Granulomatous salpingitis - high mag. (WC)
</gallery>
===Stains===
===Stains===
If organisms are seen on routine stains:
If organisms are seen on routine stains:
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*[[GMS stain]] +ve/-ve.
*[[GMS stain]] +ve/-ve.
*[[PASD stain]] +ve/-ve.
*[[PASD stain]] +ve/-ve.
==Ectopic pregnancy==
{{Main|Ectopic pregnancy}}


==Adenofibroma==
==Adenofibroma==
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*Abbreviated ''STIC''.<ref name=pmid21989347>{{Cite journal  | last1 = Visvanathan | first1 = K. | last2 = Vang | first2 = R. | last3 = Shaw | first3 = P. | last4 = Gross | first4 = A. | last5 = Soslow | first5 = R. | last6 = Parkash | first6 = V. | last7 = Shih | first7 = IeM. | last8 = Kurman | first8 = RJ. | title = Diagnosis of serous tubal intraepithelial carcinoma based on morphologic and immunohistochemical features: a reproducibility study. | journal = Am J Surg Pathol | volume = 35 | issue = 12 | pages = 1766-75 | month = Dec | year = 2011 | doi = 10.1097/PAS.0b013e31822f58bc | PMID = 21989347 }}</ref>
*Abbreviated ''STIC''.<ref name=pmid21989347>{{Cite journal  | last1 = Visvanathan | first1 = K. | last2 = Vang | first2 = R. | last3 = Shaw | first3 = P. | last4 = Gross | first4 = A. | last5 = Soslow | first5 = R. | last6 = Parkash | first6 = V. | last7 = Shih | first7 = IeM. | last8 = Kurman | first8 = RJ. | title = Diagnosis of serous tubal intraepithelial carcinoma based on morphologic and immunohistochemical features: a reproducibility study. | journal = Am J Surg Pathol | volume = 35 | issue = 12 | pages = 1766-75 | month = Dec | year = 2011 | doi = 10.1097/PAS.0b013e31822f58bc | PMID = 21989347 }}</ref>
*[[AKA]] ''tubal intraepithelial carcinoma''.
*[[AKA]] ''tubal intraepithelial carcinoma''.
{{Main|Serous tubal intraepithelial carcinoma}}


===General===
==Serous carcinoma of the fallopian tube==
*Considered the precursor lesion for tubal [[serous carcinoma]].<ref name=pmid17117391>{{Cite journal  | last1 = Lee | first1 = Y. | last2 = Miron | first2 = A. | last3 = Drapkin | first3 = R. | last4 = Nucci | first4 = MR. | last5 = Medeiros | first5 = F. | last6 = Saleemuddin | first6 = A. | last7 = Garber | first7 = J. | last8 = Birch | first8 = C. | last9 = Mou | first9 = H. | title = A candidate precursor to serous carcinoma that originates in the distal fallopian tube. | journal = J Pathol | volume = 211 | issue = 1 | pages = 26-35 | month = Jan | year = 2007 | doi = 10.1002/path.2091 | PMID = 17117391 }}</ref>
{{Main|Serous carcinoma of the fallopian tube}}
 
===Gross===
*Not apparent on gross.
*Usually at the fimbriated end of the tube.
 
===Microscopic===
Features:<ref name=pmid20228782/>
*Discrete papillary growth - low power.
*Formal criteria - need 3 or more:
*#Atypical chromatin pattern.
*#Nuclear enlargement.
*#Nuclear pleomorphism.
*#Nuclear moulding.
*#Loss of nuclear polarity ''or'' epithelial stratification.
 
Images:
*[http://www.nature.com/modpathol/journal/v23/n6/fig_tab/modpathol201060f1.html#figure-title STIC (nature.com)].<ref name=pmid20228782>{{Cite journal  | last1 = Sehdev | first1 = AS. | last2 = Kurman | first2 = RJ. | last3 = Kuhn | first3 = E. | last4 = Shih | first4 = IeM. | title = Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase. | journal = Mod Pathol | volume = 23 | issue = 6 | pages = 844-55 | month = Jun | year = 2010 | doi = 10.1038/modpathol.2010.60 | PMID = 20228782 }}</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148026/figure/F3/ STIC - schematic (nih.gov)].<ref name=pmid21683865>{{Cite journal  | last1 = Kurman | first1 = RJ. | last2 = Shih | first2 = IeM. | title = Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer--shifting the paradigm. | journal = Hum Pathol | volume = 42 | issue = 7 | pages = 918-31 | month = Jul | year = 2011 | doi = 10.1016/j.humpath.2011.03.003 | PMID = 21683865 }}</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148026/figure/F6/ STIC and STIL with p53 stain (nih.gov)].<ref name=pmid21683865/>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148026/figure/F5/ STIC - p53 stain (nih.gov)].<ref name=pmid21683865/>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860809/figure/fig1/ Small STIC - H&E and p53 (nih.gov)].<ref name=pmid20445756>{{Cite journal  | last1 = Gross | first1 = AL. | last2 = Kurman | first2 = RJ. | last3 = Vang | first3 = R. | last4 = Shih | first4 = IeM. | last5 = Visvanathan | first5 = K. | title = Precursor lesions of high-grade serous ovarian carcinoma: morphological and molecular characteristics. | journal = J Oncol | volume = 2010 | issue =  | pages = 126295 | month =  | year = 2010 | doi = 10.1155/2010/126295 | PMID = 20445756 }}</ref>
 
===IHC===
Features:<ref name=pmid21989347/>
*p53 +ve.
*Ki-67 +ve.
*p16 +ve.<ref name=pmid20228782/>
 
===External links===
*[http://www.ovariancancerprevention.org/?page_id=160 STIC training set (ovariancancerprevention.org)].


=See also=
=See also=
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[[Category:Gynecologic pathology]]
[[Category:Gynecologic pathology]]
[[Category:Uterine tubes]]
Michael
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